Detailed information of TA system TA201793

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2837103..2838706
• Replicon: chromosome
• Accession: NZ_CP074182
• Organism: Raoultella planticola strain JBIWA001

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: KGP19_RS13730
• Protein ID: WP_046852509.1
• Coordinates: 2837103..2838434 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A2X2EM10
• Locus tag: KGP19_RS13735
• Protein ID: WP_032696205.1
• Coordinates: 2838434..2838706 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP19_RS13715 (KGP19_13645)	2832979..2833893	-	915	WP_015584333.1	branched-chain amino acid ABC transporter permease	-
KGP19_RS13720 (KGP19_13650)	2833993..2835051	-	1059	WP_162180097.1	branched-chain amino acid ABC transporter substrate-binding protein	-
KGP19_RS13725 (KGP19_13655)	2835764..2837170	+	1407	WP_032699891.1	glycoside hydrolase family 10 protein	-
KGP19_RS13730 (KGP19_13660)	2837103..2838434	-	1332	WP_046852509.1	type II toxin-antitoxin system HipA family toxin	Toxin
KGP19_RS13735 (KGP19_13665)	2838434..2838706	-	273	WP_032696205.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
KGP19_RS13740 (KGP19_13670)	2838900..2839454	-	555	WP_064793779.1	RNA polymerase sigma factor	-
KGP19_RS13745 (KGP19_13675)	2839460..2839885	-	426	WP_032687741.1	hypothetical protein	-
KGP19_RS13750 (KGP19_13680)	2840017..2840970	-	954	WP_032687742.1	hypothetical protein	-
KGP19_RS13755 (KGP19_13685)	2841186..2841818	-	633	WP_064793778.1	class I SAM-dependent methyltransferase	-
KGP19_RS13760 (KGP19_13690)	2841838..2843079	-	1242	WP_046852512.1	sensor domain-containing diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 49383.68 Da
• Isoelectric Point: 6.5066

>T201793 WP_046852509.1 NZ_CP074182:c2838434-2837103 [Raoultella planticola]
MATLVTWMNNERVGELIKQANGAHLFRYEEAWMRNPRARPLSLSLPLQYGNITDDAVFNYFDNLLPDSPRVRDRIVKRYQ
ARSKQPFDLLAEIGRDSVGAVTLLPPGENATRGALSWEALDSHALDALLTAYQSDIPLGMVNEHDDFRISVAGAQEKTAL
LKIGEQWCIPTGTTPTTHIIKLPIGEIKQPDAVLDLSESVDNEYLCLALARALGFAVPRASIIQTASIRALAVERFDRRW
AQEKTVLLRLPQEDLCQAFGIPSSIKYESDGGPGIRAIMAFLVGSSEALEDRYNFMKFMVFQWLIGATDGHAKNFSIFLQ
PGGSYRLTPFYDIISAFPLLGGKGLHLSDLRLSMSLKASKGRKTEIQTLYPRHFLATAKEVGFAEEQMLEILRYFVDNVP
HAVAAVKETLPHDFSPPVYEAITDRLLWVHSRLQNAMAALPSG

Nucleotide

• Length: 1332 bp

>T201793 NZ_CP098769:328432-328800 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10168.43 Da
• Isoelectric Point: 4.9491

>AT201793 WP_032696205.1 NZ_CP074182:c2838706-2838434 [Raoultella planticola]
MSPSPGIYSPVQLANYLKLVRQKNQWTQSDLAQRMGIKQATVSNFENHPEKTTLTTVFKILQSLELSMAICEKNAPDTND
SSDNPQDLDW

Nucleotide

• Length: 273 bp

>AT201793 NZ_CP098769:328214-328435 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A2X2EM10