Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 911721..912294 Replicon chromosome
Accession NC_000921
Organism Helicobacter pylori J99

Toxin (Protein)


Gene name relE Uniprot ID Q9ZKV4
Locus tag JHP_RS04300 Protein ID WP_001880357.1
Coordinates 911721..911993 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID M3K213
Locus tag JHP_RS04305 Protein ID WP_001134114.1
Coordinates 912007..912294 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHP_RS04265 906919..907776 - 858 WP_000538063.1 SDR family oxidoreductase -
JHP_RS04270 907916..908440 + 525 WP_001135603.1 acyl-CoA thioesterase -
JHP_RS04275 908515..908817 - 303 WP_000889627.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
JHP_RS04280 908966..910294 - 1329 WP_000867414.1 transposase -
JHP_RS08390 910322..910516 + 195 Protein_834 IS200/IS605 family transposase -
JHP_RS04290 910638..910844 - 207 WP_000917077.1 hypothetical protein -
JHP_RS08455 910912..911058 - 147 WP_000820666.1 hypothetical protein -
JHP_RS04295 911422..911673 - 252 WP_001134119.1 hypothetical protein -
JHP_RS04300 911721..911993 - 273 WP_001880357.1 type II toxin-antitoxin system mRNA interferase toxin, HP0892 family Toxin
JHP_RS04305 912007..912294 - 288 WP_001134114.1 type II toxin-antitoxin system antitoxin Antitoxin
JHP_RS04310 912790..915024 - 2235 WP_000716315.1 Hop family adhesin BabA -
JHP_RS08105 916021..916431 - 411 WP_010882572.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 908966..910294 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10484.42 Da        Isoelectric Point: 9.7463

>T20179 WP_001880357.1 NC_000921:c911993-911721 [Helicobacter pylori J99]
MLTIETSKKFDKDLKILVKNGFDLKLLYKVVGNLATEQPLEPKYKDHPLKGALKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF

Download         Length: 273 bp

>T20179 NC_000921:c911993-911721 [Helicobacter pylori J99]
ATGCTGACGATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAATGGGTTTGATTTAAAGCTTTT
GTATAAAGTGGTTGGAAATTTAGCCACAGAGCAACCCCTAGAACCCAAATACAAAGACCACCCACTCAAAGGCGCTTTAA
AAGACTTTAGGGAATGCCACCTAAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAACAAGAAAACACTCTTTTTTTA
GTAAGGCTAGGCAGTCATAGCGAGCTGTTTTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11378.18 Da        Isoelectric Point: 10.4152

>AT20179 WP_001134114.1 NC_000921:c912294-912007 [Helicobacter pylori J99]
MPNTTNKDYTKYSQKQLFNFLNSIKAKQKRALEKLKEIQTQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNRL
CFKSIEDFKKHCENL

Download         Length: 288 bp

>AT20179 NC_000921:c912294-912007 [Helicobacter pylori J99]
ATGCCTAACACCACCAACAAAGACTACACAAAATACAGCCAAAAACAGCTTTTTAATTTTTTAAATTCTATCAAGGCAAA
GCAAAAAAGAGCGTTAGAAAAATTGAAAGAAATCCAAACTCAAAAGCAAAGGATTAAAAAAGCACTCCAATTTAAAGCGC
TCCATTTAACCGAAAATGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAGGACACTAAGAACCGCCTT
TGTTTTAAAAGCATAGAGGATTTTAAGAAGCATTGTGAAAACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1W0VLH9

Antitoxin

Source ID Structure
AlphaFold DB M3K213

References