Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 13521..14056 Replicon plasmid pJBIWA002_2
Accession NZ_CP074178
Organism Enterobacter asburiae strain JBIWA002

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KGP20_RS23755 Protein ID WP_223540734.1
Coordinates 13769..14056 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KGP20_RS23750 Protein ID WP_223540735.1
Coordinates 13521..13772 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP20_RS23725 (KGP20_23595) 8671..9351 - 681 WP_223540744.1 DNA methylase -
KGP20_RS23730 (KGP20_23600) 9809..10228 + 420 WP_223540743.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
KGP20_RS23735 (KGP20_23605) 10228..11502 + 1275 WP_223540820.1 Y-family DNA polymerase -
KGP20_RS23740 (KGP20_23610) 11762..12457 + 696 WP_223540819.1 ParA family protein -
KGP20_RS23745 (KGP20_23615) 12512..12802 + 291 WP_223540818.1 molecular chaperone -
KGP20_RS23750 (KGP20_23620) 13521..13772 + 252 WP_223540735.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KGP20_RS23755 (KGP20_23625) 13769..14056 + 288 WP_223540734.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KGP20_RS23760 (KGP20_23630) 14408..14743 + 336 WP_223540733.1 hypothetical protein -
KGP20_RS23765 (KGP20_23635) 15148..15780 + 633 WP_223540732.1 recombinase family protein -
KGP20_RS23770 (KGP20_23640) 16069..16767 + 699 WP_223540731.1 type VI secretion system protein TssL, short form -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..71219 71219


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11114.14 Da        Isoelectric Point: 10.5832

>T201778 WP_223540734.1 NZ_CP074178:13769-14056 [Enterobacter asburiae]
MTYKVKFRDDALKEWLKLDTVIQQQFAKKLKKCSENPHIPSAKLRGIKDCYKIKLRASGFRLVYQVINDQLIIAVVAVGK
RERSDVYNLASERMR

Download         Length: 288 bp

>T201778 NZ_CP098758:c999263-998853 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9199.45 Da        Isoelectric Point: 4.2975

>AT201778 WP_223540735.1 NZ_CP074178:13521-13772 [Enterobacter asburiae]
MPNIILSDTSASVSELKKNPMATVSSGDGYPVAILNRNQPAFYCVPAKLYEKMLDALDDQELVKLVAERSNQQLHDVDLD
SYL

Download         Length: 252 bp

>AT201778 NZ_CP098758:c999510-999244 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References