Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1646092..1646891 Replicon chromosome
Accession NZ_CP074177
Organism Enterobacter asburiae strain JBIWA002

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag KGP20_RS08360 Protein ID WP_223605048.1
Coordinates 1646092..1646469 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag KGP20_RS08365 Protein ID WP_223605049.1
Coordinates 1646526..1646891 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP20_RS08345 (KGP20_08300) 1644447..1645289 - 843 WP_193168422.1 DUF4942 domain-containing protein -
KGP20_RS08350 (KGP20_08305) 1645371..1645574 - 204 WP_193168421.1 hypothetical protein -
KGP20_RS08355 (KGP20_08310) 1645604..1646095 - 492 WP_223605047.1 DUF5983 family protein -
KGP20_RS08360 (KGP20_08315) 1646092..1646469 - 378 WP_223605048.1 TA system toxin CbtA family protein Toxin
KGP20_RS08365 (KGP20_08320) 1646526..1646891 - 366 WP_223605049.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KGP20_RS08370 (KGP20_08325) 1646915..1647136 - 222 WP_223605050.1 DUF987 domain-containing protein -
KGP20_RS08375 (KGP20_08330) 1647148..1647627 - 480 WP_223605051.1 DNA repair protein RadC -
KGP20_RS08380 (KGP20_08335) 1647639..1648049 - 411 Protein_1554 antirestriction protein -
KGP20_RS08385 (KGP20_08340) 1648137..1648391 - 255 WP_123060707.1 hypothetical protein -
KGP20_RS08390 (KGP20_08345) 1648391..1649209 - 819 WP_223605052.1 DUF932 domain-containing protein -
KGP20_RS08395 (KGP20_08350) 1649419..1649730 - 312 WP_223579897.1 hypothetical protein -
KGP20_RS08400 (KGP20_08355) 1649736..1650026 - 291 WP_223605053.1 hypothetical protein -
KGP20_RS08405 1650060..1650575 - 516 WP_223579890.1 hypothetical protein -
KGP20_RS08410 (KGP20_08365) 1650581..1651132 - 552 WP_223579887.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13821.84 Da        Isoelectric Point: 9.5455

>T201765 WP_223605048.1 NZ_CP074177:c1646469-1646092 [Enterobacter asburiae]
MQTLSAIPTRKASSRPTPVEIWQRLLTYLLERHYGLSLNDTQFGDGNVIQQYIDAGISLADALNFLVEKSELVRIDRPGF
SIQHQSPFISTIDILQARKAIGLMQRTGYKAVTCAISGRSSGGLQ

Download         Length: 378 bp

>T201765 NZ_CP098751:c942182-941949 [Brachyspira pilosicoli]
ATGAGTAAGCTAATTTTGAAGGACGCAAAAACTATAGAAAAATTGTTGTTTTTATTAGGGTTTGTTAAACATAGGCAGAA
AGGAAGTCATGCCTTTTATAAACATGAGGACGGACGATGCACTGTTATACCTTTTCACTCAAGCAAGGTAATATCAAGAC
CGCTTATGAGAAAAATATTAAATGAAATAAATCTTGATGTAGAAGAATATAATAATCTTATAGAAAAAATTTAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13394.21 Da        Isoelectric Point: 6.2030

>AT201765 WP_223605049.1 NZ_CP074177:c1646891-1646526 [Enterobacter asburiae]
MSNNTPPANHDIAEPWWGLKPAVMPCFGARLVQEGNHLHYLADRSTIEGTFSDADLRHLDQAFPLLLKQLELMLTSGELN
PRHQHSVTLYAKGLTCDADTLGSCGYLYIAIYPTSGNSILR

Download         Length: 366 bp

>AT201765 NZ_CP098751:c942400-942179 [Brachyspira pilosicoli]
ATGAAGAAAAAGTTTTTTGCATATATAGAATATGATAAAGAAACCAATGTTTATGTGGGATATATTCCTTCAATAGTTGG
GGCACATACACAGGCTGACACTTTGGAAGAGTTGCATATAAAATTAAAAGAGGTTTTGGATTTATGTCTTGAAGAGATGG
ACAGCGAAGAAAAGAAGACTATTCCAGAGTTTGTAAAAGTAGAAGAGATAGAGCTTGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References