Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 289207..289864 Replicon chromosome
Accession NZ_CP074177
Organism Enterobacter asburiae strain JBIWA002

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag KGP20_RS01630 Protein ID WP_223604683.1
Coordinates 289207..289617 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag KGP20_RS01635 Protein ID WP_010435322.1
Coordinates 289598..289864 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP20_RS01610 (KGP20_01595) 285200..286933 - 1734 WP_223604682.1 single-stranded-DNA-specific exonuclease RecJ -
KGP20_RS01615 (KGP20_01600) 286939..287652 - 714 WP_023309097.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KGP20_RS01620 (KGP20_01605) 287681..288577 - 897 WP_023309098.1 site-specific tyrosine recombinase XerD -
KGP20_RS01625 (KGP20_01610) 288679..289200 + 522 WP_008499710.1 flavodoxin FldB -
KGP20_RS01630 (KGP20_01615) 289207..289617 - 411 WP_223604683.1 protein YgfX Toxin
KGP20_RS01635 (KGP20_01620) 289598..289864 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
KGP20_RS01640 (KGP20_01625) 290159..291139 + 981 WP_223604684.1 tRNA-modifying protein YgfZ -
KGP20_RS01645 (KGP20_01630) 291213..291872 - 660 WP_023309101.1 hemolysin III family protein -
KGP20_RS01650 (KGP20_01635) 292038..292349 - 312 WP_023309102.1 N(4)-acetylcytidine aminohydrolase -
KGP20_RS01655 (KGP20_01640) 292401..293132 + 732 WP_063408213.1 MurR/RpiR family transcriptional regulator -
KGP20_RS01660 (KGP20_01645) 293249..294682 + 1434 WP_223604685.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16196.22 Da        Isoelectric Point: 11.2675

>T201760 WP_223604683.1 NZ_CP074177:c289617-289207 [Enterobacter asburiae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGRRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T201760 NZ_CP098746:c7520-7410 [Enterococcus faecalis]
GTGTTATTTGTGAAAGATTTAATGTCGTTGGTTATCGCACCGATCTTTGTAGGATTGGTTCTGGAAATGATTTCTCGTGT
GTTGGACGAGGAAGACGATAACCGAAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT201760 WP_010435322.1 NZ_CP074177:c289864-289598 [Enterobacter asburiae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT201760 NZ_CP098746:7306-7370 [Enterococcus faecalis]
AACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGATTGCTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References