Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 56712..57445 Replicon chromosome
Accession NZ_CP074177
Organism Enterobacter asburiae strain JBIWA002

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag KGP20_RS00555 Protein ID WP_223604629.1
Coordinates 57116..57445 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag KGP20_RS00550 Protein ID WP_223604628.1
Coordinates 56712..57077 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP20_RS00520 (KGP20_00505) 51741..52622 + 882 WP_223604625.1 hypothetical protein -
KGP20_RS00525 (KGP20_00510) 53294..54118 + 825 WP_223604626.1 DUF932 domain-containing protein -
KGP20_RS00530 (KGP20_00515) 54150..54593 + 444 WP_223604627.1 antirestriction protein -
KGP20_RS00535 (KGP20_00520) 54684..55903 + 1220 WP_223582561.1 IS3 family transposase -
KGP20_RS00540 (KGP20_00525) 55983..56468 + 486 WP_063156914.1 DNA repair protein RadC -
KGP20_RS00545 (KGP20_00530) 56465..56686 + 222 WP_071600415.1 DUF987 domain-containing protein -
KGP20_RS00550 (KGP20_00535) 56712..57077 + 366 WP_223604628.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KGP20_RS00555 (KGP20_00540) 57116..57445 + 330 WP_223604629.1 TA system toxin CbtA family protein Toxin
KGP20_RS00560 (KGP20_00545) 58066..58422 + 357 WP_023333137.1 hypothetical protein -
KGP20_RS00565 (KGP20_00550) 58510..58854 + 345 WP_223604630.1 cupin -
KGP20_RS00570 (KGP20_00555) 58923..59480 + 558 WP_223604631.1 YceI family protein -
KGP20_RS00575 (KGP20_00560) 59472..60263 - 792 WP_196350580.1 hypothetical protein -
KGP20_RS00580 (KGP20_00565) 60260..60790 - 531 WP_080460787.1 RNA polymerase sigma factor -
KGP20_RS00585 (KGP20_00570) 60798..61325 - 528 WP_059445673.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12324.08 Da        Isoelectric Point: 7.3215

>T201759 WP_223604629.1 NZ_CP074177:57116-57445 [Enterobacter asburiae]
MQTLSSHPTQAAQPCLSPIEIWQCLLTHLLSQHYGLTLNDTPFSNETTIREHIDAGISLSDAVNFLVEKYGLVRIDRKGF
SWQEQTPYLSVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

>T201759 NZ_CP098744:c61558-60695 [Enterococcus faecalis]
ATGGCGAATATTACTGACTTCACCGAAAAGCAATTTGAAGATCGTTTAGAAAAGAATGTTGAACGACTAACTAAAAATAG
ACTAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGATCAGGTAAAACTAGTTTGCGATCGGCAATTT
CCGAAGAGACACAAGGAAATGTTGTTATCATTGATAATGATACGTTCAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAACTTTATGAAAAAGACGTAGTAAAATACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
AGATAAAGGGTATAATTTAGTGATTGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGATTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGGTATGAA
ACTATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GCTTAGAAACGCCTTCCATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGGTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
AATGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGGATTTAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13558.33 Da        Isoelectric Point: 6.3148

>AT201759 WP_223604628.1 NZ_CP074177:56712-57077 [Enterobacter asburiae]
MNNHSESGTKPESPACQRWGLKRAITPCFGARLVQEGNRVHFLADRAGFNGAFSDNDALRLDQAFPLMLKQLELMLISSE
LNPRYQHCVTLYHNGLTCEADTLGSCGYVYIAIYPEQTEPH

Download         Length: 366 bp

>AT201759 NZ_CP098744:c61832-61560 [Enterococcus faecalis]
ATGGCAGTTACGTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAACTAGATACTAAAAATACTCGTTTACTAGAAGTGAATCTTTTAAATCAATTAGAAGTGGCAC
AAGAAGTTGATTTATTTCAACAACCATTTGAAGAATTACAAGCTATTCATGAGTATTGGCGGTCAATGAATCAATATTCA
AAACAAATTTTGACAAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References