Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 90708..91345 Replicon plasmid pJBIWA003_1
Accession NZ_CP074171
Organism Enterobacter sp. JBIWA003

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag KGP25_RS24870 Protein ID WP_123061016.1
Coordinates 90708..91118 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag KGP25_RS24875 Protein ID WP_123061017.1
Coordinates 91115..91345 (-) Length 77 a.a.

Genomic Context


KGP25_RS24835KGP25_RS24840KGP25_RS24845KGP25_RS24855KGP25_RS24860KGP25_RS24865KGP25_RS24880KGP25_RS24885KGP25_RS24890KGP25_RS24895KGP25_RS24900KGP25_RS24905KGP25_RS24915KGP25_RS24920KGP25_RS24850KGP25_RS24870KGP25_RS24875KGP25_RS24910
Location: 86547..87107 (561 bp)
Type: Others
Protein ID: WP_223540696.1
Location: 87100..87882 (783 bp)
Type: Others
Protein ID: WP_123061154.1
Location: 87866..88171 (306 bp)
Type: Others
Protein ID: WP_223540697.1
Location: 89159..89545 (387 bp)
Type: Others
Protein ID: WP_223540698.1
Location: 89758..90381 (624 bp)
Type: Others
Protein ID: WP_223540699.1
Location: 90447..90626 (180 bp)
Type: Others
Protein ID: Protein_89
Location: 91329..91799 (471 bp)
Type: Others
Protein ID: Protein_92
Location: 91972..92190 (219 bp)
Type: Others
Protein ID: WP_123061018.1
Location: 92192..92497 (306 bp)
Type: Others
Protein ID: WP_123061019.1
Location: 92585..93364 (780 bp)
Type: Others
Protein ID: WP_223540700.1
Location: 93668..94288 (621 bp)
Type: Others
Protein ID: WP_123061021.1
Location: 94341..94571 (231 bp)
Type: Others
Protein ID: WP_017694173.1
Location: 95305..95985 (681 bp)
Type: Others
Protein ID: WP_123061023.1
Location: 95982..96206 (225 bp)
Type: Others
Protein ID: WP_123061024.1
Location: 88254..88777 (524 bp)
Type: Others
Protein ID: Protein_86
Location: 90708..91118 (411 bp)
Type: Toxin
Protein ID: WP_123061016.1
Location: 91115..91345 (231 bp)
Type: Antitoxin
Protein ID: WP_123061017.1
Location: 94604..94804 (201 bp)
Type: Others
Protein ID: WP_017694174.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KGP25_RS24835 (KGP25_24700)86547..87107+561WP_223540696.1fertility inhibition protein FinO-
KGP25_RS24840 (KGP25_24705)87100..87882+783WP_123061154.1DsbA family protein-
KGP25_RS24845 (KGP25_24710)87866..88171+306WP_223540697.1cytoplasmic protein-
KGP25_RS24850 (KGP25_24715)88254..88777-524Protein_86IS1 family transposase-
KGP25_RS24855 (KGP25_24720)89159..89545+387WP_223540698.1ProQ/FINO family protein-
KGP25_RS24860 (KGP25_24725)89758..90381+624WP_223540699.1helix-turn-helix domain-containing protein-
KGP25_RS24865 (KGP25_24730)90447..90626+180Protein_89IS110 family transposase-
KGP25_RS24870 (KGP25_24735)90708..91118-411WP_123061016.1PIN domain-containing proteinToxin
KGP25_RS24875 (KGP25_24740)91115..91345-231WP_123061017.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
KGP25_RS2488091329..91799+471Protein_92hypothetical protein-
KGP25_RS24885 (KGP25_24745)91972..92190+219WP_123061018.1type II toxin-antitoxin system antitoxin CcdA-
KGP25_RS24890 (KGP25_24750)92192..92497+306WP_123061019.1type II toxin-antitoxin system toxin CcdB-
KGP25_RS24895 (KGP25_24755)92585..93364+780WP_223540700.1site-specific integrase-
KGP25_RS24900 (KGP25_24760)93668..94288+621WP_123061021.1ParA family protein-
KGP25_RS24905 (KGP25_24765)94341..94571+231WP_017694173.1plasmid partition protein ParG-
KGP25_RS24910 (KGP25_24770)94604..94804-201WP_017694174.1hypothetical protein-
KGP25_RS24915 (KGP25_24775)95305..95985+681WP_123061023.1DNA methylase-
KGP25_RS24920 (KGP25_24780)95982..96206+225WP_123061024.1hypothetical protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidoqxB / oqxA / blaFRI-5vipA/tssB / vipB/tssC / vasE/tssK / dotU/tssL / hcp/tssD / clpV/tssH / vgrG/tssI / tli1 / tli1 / tle1 / KPHS_23120 / icmF/tssM / tssF / tssG / sciN/tssJ1..221552221552


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-118)

Antitoxin

(7-48)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 14665.00 Da        Isoelectric Point: 6.4606

>T201751 WP_123061016.1 NZ_CP074171:c91118-90708 [Enterobacter sp. JBIWA003]
VNKTYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITWSEISFAARAAGPVTQQLAEAFCARLDAILPWDRAAV
DATTEVKVALRLAGTPPGPNDTAIAGHAIAAGAVLVTRIGGEFERVPGLMLEDWVK

Download         Length: 411 bp

>T201751 NZ_CP098742:c100656-100351 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8654.78 Da        Isoelectric Point: 4.7571

>AT201751 WP_123061017.1 NZ_CP074171:c91345-91115 [Enterobacter sp. JBIWA003]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELVIVREGDSIILRPVRPTWGSFAQFEKADPDFMAERGDVVSDEGRFNL

Download         Length: 231 bp

>AT201751 NZ_CP098742:c100876-100658 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References