Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vagCD/VapC-VagC |
Location | 90708..91345 | Replicon | plasmid pJBIWA003_1 |
Accession | NZ_CP074171 | ||
Organism | Enterobacter sp. JBIWA003 |
Toxin (Protein)
Gene name | vagD | Uniprot ID | - |
Locus tag | KGP25_RS24870 | Protein ID | WP_123061016.1 |
Coordinates | 90708..91118 (-) | Length | 137 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | - |
Locus tag | KGP25_RS24875 | Protein ID | WP_123061017.1 |
Coordinates | 91115..91345 (-) | Length | 77 a.a. |
Genomic Context
Location: 86547..87107 (561 bp)
Type: Others
Protein ID: WP_223540696.1
Type: Others
Protein ID: WP_223540696.1
Location: 87100..87882 (783 bp)
Type: Others
Protein ID: WP_123061154.1
Type: Others
Protein ID: WP_123061154.1
Location: 87866..88171 (306 bp)
Type: Others
Protein ID: WP_223540697.1
Type: Others
Protein ID: WP_223540697.1
Location: 89159..89545 (387 bp)
Type: Others
Protein ID: WP_223540698.1
Type: Others
Protein ID: WP_223540698.1
Location: 89758..90381 (624 bp)
Type: Others
Protein ID: WP_223540699.1
Type: Others
Protein ID: WP_223540699.1
Location: 90447..90626 (180 bp)
Type: Others
Protein ID: Protein_89
Type: Others
Protein ID: Protein_89
Location: 91329..91799 (471 bp)
Type: Others
Protein ID: Protein_92
Type: Others
Protein ID: Protein_92
Location: 91972..92190 (219 bp)
Type: Others
Protein ID: WP_123061018.1
Type: Others
Protein ID: WP_123061018.1
Location: 92192..92497 (306 bp)
Type: Others
Protein ID: WP_123061019.1
Type: Others
Protein ID: WP_123061019.1
Location: 92585..93364 (780 bp)
Type: Others
Protein ID: WP_223540700.1
Type: Others
Protein ID: WP_223540700.1
Location: 93668..94288 (621 bp)
Type: Others
Protein ID: WP_123061021.1
Type: Others
Protein ID: WP_123061021.1
Location: 94341..94571 (231 bp)
Type: Others
Protein ID: WP_017694173.1
Type: Others
Protein ID: WP_017694173.1
Location: 95305..95985 (681 bp)
Type: Others
Protein ID: WP_123061023.1
Type: Others
Protein ID: WP_123061023.1
Location: 95982..96206 (225 bp)
Type: Others
Protein ID: WP_123061024.1
Type: Others
Protein ID: WP_123061024.1
Location: 88254..88777 (524 bp)
Type: Others
Protein ID: Protein_86
Type: Others
Protein ID: Protein_86
Location: 90708..91118 (411 bp)
Type: Toxin
Protein ID: WP_123061016.1
Type: Toxin
Protein ID: WP_123061016.1
Location: 91115..91345 (231 bp)
Type: Antitoxin
Protein ID: WP_123061017.1
Type: Antitoxin
Protein ID: WP_123061017.1
Location: 94604..94804 (201 bp)
Type: Others
Protein ID: WP_017694174.1
Type: Others
Protein ID: WP_017694174.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KGP25_RS24835 (KGP25_24700) | 86547..87107 | + | 561 | WP_223540696.1 | fertility inhibition protein FinO | - |
KGP25_RS24840 (KGP25_24705) | 87100..87882 | + | 783 | WP_123061154.1 | DsbA family protein | - |
KGP25_RS24845 (KGP25_24710) | 87866..88171 | + | 306 | WP_223540697.1 | cytoplasmic protein | - |
KGP25_RS24850 (KGP25_24715) | 88254..88777 | - | 524 | Protein_86 | IS1 family transposase | - |
KGP25_RS24855 (KGP25_24720) | 89159..89545 | + | 387 | WP_223540698.1 | ProQ/FINO family protein | - |
KGP25_RS24860 (KGP25_24725) | 89758..90381 | + | 624 | WP_223540699.1 | helix-turn-helix domain-containing protein | - |
KGP25_RS24865 (KGP25_24730) | 90447..90626 | + | 180 | Protein_89 | IS110 family transposase | - |
KGP25_RS24870 (KGP25_24735) | 90708..91118 | - | 411 | WP_123061016.1 | PIN domain-containing protein | Toxin |
KGP25_RS24875 (KGP25_24740) | 91115..91345 | - | 231 | WP_123061017.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
KGP25_RS24880 | 91329..91799 | + | 471 | Protein_92 | hypothetical protein | - |
KGP25_RS24885 (KGP25_24745) | 91972..92190 | + | 219 | WP_123061018.1 | type II toxin-antitoxin system antitoxin CcdA | - |
KGP25_RS24890 (KGP25_24750) | 92192..92497 | + | 306 | WP_123061019.1 | type II toxin-antitoxin system toxin CcdB | - |
KGP25_RS24895 (KGP25_24755) | 92585..93364 | + | 780 | WP_223540700.1 | site-specific integrase | - |
KGP25_RS24900 (KGP25_24760) | 93668..94288 | + | 621 | WP_123061021.1 | ParA family protein | - |
KGP25_RS24905 (KGP25_24765) | 94341..94571 | + | 231 | WP_017694173.1 | plasmid partition protein ParG | - |
KGP25_RS24910 (KGP25_24770) | 94604..94804 | - | 201 | WP_017694174.1 | hypothetical protein | - |
KGP25_RS24915 (KGP25_24775) | 95305..95985 | + | 681 | WP_123061023.1 | DNA methylase | - |
KGP25_RS24920 (KGP25_24780) | 95982..96206 | + | 225 | WP_123061024.1 | hypothetical protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | oqxB / oqxA / blaFRI-5 | vipA/tssB / vipB/tssC / vasE/tssK / dotU/tssL / hcp/tssD / clpV/tssH / vgrG/tssI / tli1 / tli1 / tle1 / KPHS_23120 / icmF/tssM / tssF / tssG / sciN/tssJ | 1..221552 | 221552 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 137 a.a. Molecular weight: 14665.00 Da Isoelectric Point: 6.4606
>T201751 WP_123061016.1 NZ_CP074171:c91118-90708 [Enterobacter sp. JBIWA003]
VNKTYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITWSEISFAARAAGPVTQQLAEAFCARLDAILPWDRAAV
DATTEVKVALRLAGTPPGPNDTAIAGHAIAAGAVLVTRIGGEFERVPGLMLEDWVK
VNKTYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITWSEISFAARAAGPVTQQLAEAFCARLDAILPWDRAAV
DATTEVKVALRLAGTPPGPNDTAIAGHAIAAGAVLVTRIGGEFERVPGLMLEDWVK
Download Length: 411 bp
>T201751 NZ_CP098742:c100656-100351 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8654.78 Da Isoelectric Point: 4.7571
>AT201751 WP_123061017.1 NZ_CP074171:c91345-91115 [Enterobacter sp. JBIWA003]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELVIVREGDSIILRPVRPTWGSFAQFEKADPDFMAERGDVVSDEGRFNL
MRTVSIFKNGNNRAIRLPRDLDFEGVSELVIVREGDSIILRPVRPTWGSFAQFEKADPDFMAERGDVVSDEGRFNL
Download Length: 231 bp
>AT201751 NZ_CP098742:c100876-100658 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA