Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4250834..4251633 Replicon chromosome
Accession NZ_CP074170
Organism Enterobacter sp. JBIWA003

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag KGP25_RS20580 Protein ID WP_123060711.1
Coordinates 4251256..4251633 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag KGP25_RS20575 Protein ID WP_123060710.1
Coordinates 4250834..4251199 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP25_RS20530 (KGP25_20410) 4246239..4246646 + 408 WP_032233521.1 hypothetical protein -
KGP25_RS20535 (KGP25_20415) 4246718..4246945 + 228 WP_123060703.1 hypothetical protein -
KGP25_RS20540 (KGP25_20420) 4247248..4248084 + 837 WP_123060705.1 hypothetical protein -
KGP25_RS20545 (KGP25_20425) 4248178..4248411 + 234 WP_123060706.1 DUF905 domain-containing protein -
KGP25_RS20550 (KGP25_20430) 4248515..4249333 + 819 WP_143345534.1 DUF932 domain-containing protein -
KGP25_RS20555 (KGP25_20435) 4249333..4249587 + 255 WP_123060707.1 hypothetical protein -
KGP25_RS20560 (KGP25_20440) 4249675..4250085 + 411 Protein_4014 antirestriction protein -
KGP25_RS20565 (KGP25_20445) 4250097..4250561 + 465 WP_123060708.1 DNA repair protein RadC -
KGP25_RS20570 (KGP25_20450) 4250590..4250811 + 222 WP_123060709.1 DUF987 domain-containing protein -
KGP25_RS20575 (KGP25_20455) 4250834..4251199 + 366 WP_123060710.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KGP25_RS20580 (KGP25_20460) 4251256..4251633 + 378 WP_123060711.1 TA system toxin CbtA family protein Toxin
KGP25_RS20585 (KGP25_20465) 4251630..4252082 + 453 WP_143345536.1 DUF5983 family protein -
KGP25_RS20590 (KGP25_20470) 4252151..4252354 + 204 WP_123060713.1 DUF957 domain-containing protein -
KGP25_RS20595 (KGP25_20475) 4252436..4253278 + 843 WP_123060714.1 DUF4942 domain-containing protein -
KGP25_RS20605 (KGP25_20490) 4255381..4256199 + 819 WP_223539555.1 DUF4225 domain-containing protein -
KGP25_RS20610 (KGP25_20495) 4256177..4256503 - 327 WP_039265473.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4208182..4257364 49182


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13754.84 Da        Isoelectric Point: 9.9983

>T201749 WP_123060711.1 NZ_CP074170:4251256-4251633 [Enterobacter sp. JBIWA003]
MQTLSAIPARKAPSHPTPVEIWQRLLTYLLERHYGLSLNDTQFGNDGVIQQHIDAGLSLADALNFLVEKSELVRIDRPGF
SIQHQSPFISAIDILRARKAIGLMQRTGYKAVTCAISGRSSGGLK

Download         Length: 378 bp

>T201749 NZ_CP098741:c4697031-4696747 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13398.24 Da        Isoelectric Point: 5.9501

>AT201749 WP_123060710.1 NZ_CP074170:4250834-4251199 [Enterobacter sp. JBIWA003]
MPNTTPVANHDISEPWWGLKPTVTPCFGARLVQEGNHLHYLADRSTIEGTFSDADLRHLDQAFPVLMKQLELMLVSGELN
PRNQHCVTLYAKGLTLDADTLGSCGYLYIAIYPTSGNSIPR

Download         Length: 366 bp

>AT201749 NZ_CP098741:c4697269-4697021 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References