Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4126378..4127035 Replicon chromosome
Accession NZ_CP074170
Organism Enterobacter sp. JBIWA003

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag KGP25_RS19955 Protein ID WP_021242050.1
Coordinates 4126378..4126788 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag KGP25_RS19960 Protein ID WP_006178375.1
Coordinates 4126769..4127035 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP25_RS19935 (KGP25_19815) 4122371..4124104 - 1734 WP_223539528.1 single-stranded-DNA-specific exonuclease RecJ -
KGP25_RS19940 (KGP25_19820) 4124110..4124823 - 714 WP_023333302.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KGP25_RS19945 (KGP25_19825) 4124852..4125748 - 897 WP_008499709.1 site-specific tyrosine recombinase XerD -
KGP25_RS19950 (KGP25_19830) 4125850..4126371 + 522 WP_045909912.1 flavodoxin FldB -
KGP25_RS19955 (KGP25_19835) 4126378..4126788 - 411 WP_021242050.1 protein YgfX Toxin
KGP25_RS19960 (KGP25_19840) 4126769..4127035 - 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
KGP25_RS19965 (KGP25_19845) 4127330..4128310 + 981 WP_045909913.1 tRNA-modifying protein YgfZ -
KGP25_RS19970 (KGP25_19850) 4128395..4129054 - 660 WP_223539529.1 hemolysin III family protein -
KGP25_RS19975 (KGP25_19855) 4129321..4130052 + 732 WP_223540586.1 MurR/RpiR family transcriptional regulator -
KGP25_RS19980 (KGP25_19860) 4130169..4131602 + 1434 WP_223539530.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T201748 WP_021242050.1 NZ_CP074170:c4126788-4126378 [Enterobacter sp. JBIWA003]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T201748 NZ_CP098741:c3641393-3641175 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT201748 WP_006178375.1 NZ_CP074170:c4127035-4126769 [Enterobacter sp. JBIWA003]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT201748 NZ_CP098741:c3641795-3641421 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References