Detailed information of TA system TA201738

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 1643349..1644262
• Replicon: chromosome
• Accession: NZ_CP074170
• Organism: Enterobacter sp. JBIWA003

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: KGP25_RS07815
• Protein ID: WP_223540216.1
• Coordinates: 1643349..1643822 (-)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A8B2SER9
• Locus tag: KGP25_RS07820
• Protein ID: WP_023327017.1
• Coordinates: 1643819..1644262 (-)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP25_RS07795 (KGP25_07765)	1639509..1640819	+	1311	WP_223540213.1	type I-F CRISPR-associated protein Csy1	-
KGP25_RS07800 (KGP25_07770)	1640816..1641751	+	936	WP_223540214.1	type I-F CRISPR-associated protein Csy2	-
KGP25_RS07805 (KGP25_07775)	1641765..1642763	+	999	WP_223540215.1	type I-F CRISPR-associated protein Csy3	-
KGP25_RS07810 (KGP25_07780)	1642773..1643327	+	555	WP_048027175.1	type I-F CRISPR-associated endoribonuclease Cas6/Csy4	-
KGP25_RS07815 (KGP25_07785)	1643349..1643822	-	474	WP_223540216.1	RES domain-containing protein	Toxin
KGP25_RS07820 (KGP25_07790)	1643819..1644262	-	444	WP_023327017.1	DUF2384 domain-containing protein	Antitoxin
KGP25_RS07825 (KGP25_07795)	1647227..1647445	-	219	WP_002211347.1	translation initiation factor IF-1	-
KGP25_RS07830 (KGP25_07800)	1647730..1648434	-	705	WP_126534815.1	leucyl/phenylalanyl-tRNA--protein transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-144)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 17549.82 Da
• Isoelectric Point: 5.0701

>T201738 WP_223540216.1 NZ_CP074170:c1643822-1643349 [Enterobacter sp. JBIWA003]
MIFYRLVTGRYASEAWSGSGANQYGGRWNHKGHPAVYVSTSISLASLEILVHVRKDTVLNQYQLFSIDIPDDQIDYLDKA
WLPEDWQENPAPVSTMDLGTGWLQANSALALILPSSIIPYENNAILNPLHPAFHPALNSVQQLPFVFDTRLTEKTAP

Nucleotide

• Length: 474 bp

>T201738 NZ_CP098741:c1420112-1419699 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16352.68 Da
• Isoelectric Point: 7.2062

>AT201738 WP_023327017.1 NZ_CP074170:c1644262-1643819 [Enterobacter sp. JBIWA003]
MRTWIPAQKPADNALWRYAGLPANRGMRLIEFLNQGLPVSVLDNIHEWTSMSKADILRVTGINERNVARRKSAGRTLTPD
ESERVARFVRVLDAAVDYFGSKEEAWTWLQAPVRGLGNVAPVDLIATETGALEVTDLIGRLEHGVFA

Nucleotide

• Length: 444 bp

>AT201738 NZ_CP098741:c1420359-1420093 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A8B2SER9