Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 644661..645344 Replicon chromosome
Accession NZ_CP074170
Organism Enterobacter sp. JBIWA003

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag KGP25_RS03105 Protein ID WP_223539952.1
Coordinates 645003..645344 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag KGP25_RS03100 Protein ID WP_223540533.1
Coordinates 644661..644978 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP25_RS03060 (KGP25_03050) 639876..640631 + 756 WP_223539944.1 50S ribosome-binding GTPase -
KGP25_RS03065 (KGP25_03055) 640940..641491 + 552 WP_223539945.1 hypothetical protein -
KGP25_RS03070 (KGP25_03060) 641496..642122 + 627 WP_223539946.1 hypothetical protein -
KGP25_RS03075 (KGP25_03065) 642332..643150 + 819 WP_223539947.1 DUF932 domain-containing protein -
KGP25_RS03080 (KGP25_03070) 643150..643404 + 255 WP_223539948.1 hypothetical protein -
KGP25_RS03085 (KGP25_03075) 643421..643894 + 474 WP_223539949.1 antirestriction protein -
KGP25_RS03090 (KGP25_03080) 643906..644385 + 480 WP_223539950.1 DNA repair protein RadC -
KGP25_RS03095 (KGP25_03085) 644405..644617 + 213 WP_223539951.1 DUF987 family protein -
KGP25_RS03100 (KGP25_03090) 644661..644978 + 318 WP_223540533.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KGP25_RS03105 (KGP25_03095) 645003..645344 + 342 WP_223539952.1 TA system toxin CbtA family protein Toxin
KGP25_RS03110 (KGP25_03100) 645448..645689 + 242 Protein_599 restriction endonuclease subunit M -
KGP25_RS03115 (KGP25_03105) 645780..645962 + 183 WP_105576963.1 hypothetical protein -
KGP25_RS03120 (KGP25_03110) 646012..647184 + 1173 WP_223539953.1 DNA methyltransferase -
KGP25_RS03125 (KGP25_03115) 647192..648691 + 1500 WP_223539954.1 DNA methyltransferase -
KGP25_RS03130 (KGP25_03120) 648721..650160 - 1440 WP_223539955.1 phospholipase D-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 634755..659950 25195


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(4-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12834.78 Da        Isoelectric Point: 7.8807

>T201736 WP_223539952.1 NZ_CP074170:645003-645344 [Enterobacter sp. JBIWA003]
MKTLPVTTQRATKPCPSPVTVWQMLLTRLLEQHYGLTLNDTLFSDETVIQEHINAGITLADAVNFLVEKYELVRIDRRGV
NCQEQSPYLGAVDILRARQATGLLRYRHNTPSL

Download         Length: 342 bp

>T201736 NZ_CP098741:1261287-1261814 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11783.52 Da        Isoelectric Point: 6.6208

>AT201736 WP_223540533.1 NZ_CP074170:644661-644978 [Enterobacter sp. JBIWA003]
IADPWWGLKPAAIPCFGARLVQEGNRLHYMADRASITGIFGDAECLKLEEAFPHFIRQIELSLNTGELKARHAHCVTLYH
NAFTCEADTLGSCGYVYIVIYPTQR

Download         Length: 318 bp

>AT201736 NZ_CP098741:1261000-1261290 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References