Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 44171..44832 Replicon chromosome
Accession NZ_CP074170
Organism Enterobacter sp. JBIWA003

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KGP25_RS00225 Protein ID WP_023293716.1
Coordinates 44434..44832 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KGP25_RS00220 Protein ID WP_111967631.1
Coordinates 44171..44437 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP25_RS00195 (KGP25_00195) 40235..41563 - 1329 WP_008500133.1 PTS cellobiose transporter subunit IIC -
KGP25_RS00200 (KGP25_00200) 41575..41889 - 315 WP_008500132.1 PTS sugar transporter subunit IIB -
KGP25_RS00205 (KGP25_00205) 42183..43133 + 951 WP_008500131.1 LacI family DNA-binding transcriptional regulator -
KGP25_RS00210 (KGP25_00210) 43184..43480 - 297 WP_044597403.1 YicS family protein -
KGP25_RS00215 (KGP25_00215) 43622..44041 + 420 WP_223539741.1 GNAT family N-acetyltransferase -
KGP25_RS00220 (KGP25_00220) 44171..44437 + 267 WP_111967631.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KGP25_RS00225 (KGP25_00225) 44434..44832 + 399 WP_023293716.1 type II toxin-antitoxin system VapC family toxin Toxin
KGP25_RS00230 (KGP25_00230) 44972..45772 + 801 WP_223539742.1 lipoprotein NlpA -
KGP25_RS00235 (KGP25_00235) 45896..46675 + 780 WP_223539744.1 MBL fold metallo-hydrolase -
KGP25_RS00240 (KGP25_00240) 46702..47655 + 954 WP_223539745.1 helix-turn-helix domain-containing protein -
KGP25_RS00245 (KGP25_00245) 47838..49535 + 1698 WP_223540610.1 ShlB/FhaC/HecB family hemolysin secretion/activation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14799.00 Da        Isoelectric Point: 6.4779

>T201735 WP_023293716.1 NZ_CP074170:44434-44832 [Enterobacter sp. JBIWA003]
MRHMLDTNIVSHLFKRHPEVVSRMTCLAPGDVCISSITEAELLYGADKKKSSRLKETIREFLNTITICDWDSDAAATYGE
LRATLEKKGKVMGDLDQLIAAHAISRGTTIVTNDRAFRMVQELAVEDWTTTL

Download         Length: 399 bp

>T201735 NZ_CP098741:c214907-214804 [Salmonella enterica subsp. enterica serovar Typhimurium]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9979.31 Da        Isoelectric Point: 4.6310

>AT201735 WP_111967631.1 NZ_CP074170:44171-44437 [Enterobacter sp. JBIWA003]
MERTAKLFRKGQNQAVMLPAEFAFDAESVYIRRDEEGNVVLAAKPVLIKSWDNFLRMLAETDVPDTFLSKEERNQSVTTR
DPLDGACS

Download         Length: 267 bp

>AT201735 NZ_CP098741:214802-214947 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References