Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 23720..24285 Replicon plasmid pJBIWA004_1
Accession NZ_CP074169
Organism Serratia ureilytica strain JBIWA004

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KGP23_RS24360 Protein ID WP_223525194.1
Coordinates 23989..24285 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KGP23_RS24355 Protein ID WP_223525192.1
Coordinates 23720..23992 (+) Length 91 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP23_RS24335 (KGP23_24275) 18741..20840 + 2100 WP_223525187.1 peptidase domain-containing ABC transporter -
KGP23_RS24340 (KGP23_24280) 20897..21145 - 249 WP_126502361.1 hypothetical protein -
KGP23_RS24345 (KGP23_24285) 21533..21883 + 351 WP_223525189.1 hypothetical protein -
KGP23_RS24350 (KGP23_24290) 22120..22851 - 732 WP_223525190.1 2OG-Fe(II) oxygenase -
KGP23_RS24355 (KGP23_24295) 23720..23992 + 273 WP_223525192.1 ribbon-helix-helix protein, CopG family Antitoxin
KGP23_RS24360 (KGP23_24300) 23989..24285 + 297 WP_223525194.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KGP23_RS24365 (KGP23_24305) 24387..24602 + 216 Protein_28 IS6 family transposase -
KGP23_RS24370 (KGP23_24310) 24886..25409 + 524 Protein_29 IS3 family transposase -
KGP23_RS24375 (KGP23_24315) 25552..26430 - 879 WP_223174988.1 carbapenem-hydrolyzing class A beta-lactamase IMI-22 -
KGP23_RS24380 (KGP23_24320) 26905..27579 - 675 Protein_31 IS6 family transposase -
KGP23_RS24385 (KGP23_24325) 27925..28152 - 228 WP_223525196.1 plasmid partition protein ParG -
KGP23_RS24390 (KGP23_24330) 28200..28820 - 621 WP_223525198.1 ParA family partition ATPase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaNMC-A - 1..106702 106702
- flank IS/Tn blaNMC-A - 25552..27579 2027


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11685.54 Da        Isoelectric Point: 8.0232

>T201734 WP_223525194.1 NZ_CP074169:23989-24285 [Serratia ureilytica]
MIFEWTVPARDDVIRLYNFLAKKNERAAAKVVRSLVDAPTTLLLNPRRGEIVVDYEPREVRRCIVGSYEMHYELKGDSLI
ILRIWHQREERLWQGFVE

Download         Length: 297 bp

>T201734 NZ_CP098740:2505212-2505475 [Streptomyces drozdowiczii]
GTGAGTAAGTACCGAACCGTCTTTCGCCCCGAGGCGCAGGCCGAGCTACGGAAGATCCCTCGCGGCATGGCCCTGCGCAT
CCTGGCCAAACTGGCCGAGCTGGAGAGCGATCCCCTGGGCTTCAACACCACCGCGCTCGTGTCACAGCCGGACCGTCGCC
GCCTGCGAGTCGGCGACTACCGAGTCGTGTACACGATCGACAACGGAGAGGTCGTGGTGTGGGTCGTCCATATCGGTCAT
CGCTCCACCGTGTACGACACCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10040.47 Da        Isoelectric Point: 5.8235

>AT201734 WP_223525192.1 NZ_CP074169:23720-23992 [Serratia ureilytica]
MTANRTITAPLPAEMAKKVDVWAEKNGRTRSWLVREAVGQFLAREAQRDFLIQEALVAVDLGQVISHEDMVAWAASLGTD
NQQLPPEPRK

Download         Length: 273 bp

>AT201734 NZ_CP098740:2504950-2505219 [Streptomyces drozdowiczii]
ATGACGCAGCCGCAACCCATAGAGTCCATCCGCGCCGTACGCGCGCACCTGGCGGAGGTCGTGGAGCGTGCCGACCGGGA
CGACGTACCCACCGTGATCACCCGACGGGGCAAGCAGGTCGCCGCCATCGTCTCCATCGAGGTGCTGCGCAAGTACCAGG
AGTGGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGTATGGCCGACTCCGCACCCGGCATCCCGATCGAGGACGTC
ATGAGGGAGACGCTGGAACGCGGTGAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References