Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
Location | 23720..24285 | Replicon | plasmid pJBIWA004_1 |
Accession | NZ_CP074169 | ||
Organism | Serratia ureilytica strain JBIWA004 |
Toxin (Protein)
Gene name | relE | Uniprot ID | - |
Locus tag | KGP23_RS24360 | Protein ID | WP_223525194.1 |
Coordinates | 23989..24285 (+) | Length | 99 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | - |
Locus tag | KGP23_RS24355 | Protein ID | WP_223525192.1 |
Coordinates | 23720..23992 (+) | Length | 91 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KGP23_RS24335 (KGP23_24275) | 18741..20840 | + | 2100 | WP_223525187.1 | peptidase domain-containing ABC transporter | - |
KGP23_RS24340 (KGP23_24280) | 20897..21145 | - | 249 | WP_126502361.1 | hypothetical protein | - |
KGP23_RS24345 (KGP23_24285) | 21533..21883 | + | 351 | WP_223525189.1 | hypothetical protein | - |
KGP23_RS24350 (KGP23_24290) | 22120..22851 | - | 732 | WP_223525190.1 | 2OG-Fe(II) oxygenase | - |
KGP23_RS24355 (KGP23_24295) | 23720..23992 | + | 273 | WP_223525192.1 | ribbon-helix-helix protein, CopG family | Antitoxin |
KGP23_RS24360 (KGP23_24300) | 23989..24285 | + | 297 | WP_223525194.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
KGP23_RS24365 (KGP23_24305) | 24387..24602 | + | 216 | Protein_28 | IS6 family transposase | - |
KGP23_RS24370 (KGP23_24310) | 24886..25409 | + | 524 | Protein_29 | IS3 family transposase | - |
KGP23_RS24375 (KGP23_24315) | 25552..26430 | - | 879 | WP_223174988.1 | carbapenem-hydrolyzing class A beta-lactamase IMI-22 | - |
KGP23_RS24380 (KGP23_24320) | 26905..27579 | - | 675 | Protein_31 | IS6 family transposase | - |
KGP23_RS24385 (KGP23_24325) | 27925..28152 | - | 228 | WP_223525196.1 | plasmid partition protein ParG | - |
KGP23_RS24390 (KGP23_24330) | 28200..28820 | - | 621 | WP_223525198.1 | ParA family partition ATPase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | blaNMC-A | - | 1..106702 | 106702 | |
- | flank | IS/Tn | blaNMC-A | - | 25552..27579 | 2027 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11685.54 Da Isoelectric Point: 8.0232
>T201734 WP_223525194.1 NZ_CP074169:23989-24285 [Serratia ureilytica]
MIFEWTVPARDDVIRLYNFLAKKNERAAAKVVRSLVDAPTTLLLNPRRGEIVVDYEPREVRRCIVGSYEMHYELKGDSLI
ILRIWHQREERLWQGFVE
MIFEWTVPARDDVIRLYNFLAKKNERAAAKVVRSLVDAPTTLLLNPRRGEIVVDYEPREVRRCIVGSYEMHYELKGDSLI
ILRIWHQREERLWQGFVE
Download Length: 297 bp
>T201734 NZ_CP098740:2505212-2505475 [Streptomyces drozdowiczii]
GTGAGTAAGTACCGAACCGTCTTTCGCCCCGAGGCGCAGGCCGAGCTACGGAAGATCCCTCGCGGCATGGCCCTGCGCAT
CCTGGCCAAACTGGCCGAGCTGGAGAGCGATCCCCTGGGCTTCAACACCACCGCGCTCGTGTCACAGCCGGACCGTCGCC
GCCTGCGAGTCGGCGACTACCGAGTCGTGTACACGATCGACAACGGAGAGGTCGTGGTGTGGGTCGTCCATATCGGTCAT
CGCTCCACCGTGTACGACACCTGA
GTGAGTAAGTACCGAACCGTCTTTCGCCCCGAGGCGCAGGCCGAGCTACGGAAGATCCCTCGCGGCATGGCCCTGCGCAT
CCTGGCCAAACTGGCCGAGCTGGAGAGCGATCCCCTGGGCTTCAACACCACCGCGCTCGTGTCACAGCCGGACCGTCGCC
GCCTGCGAGTCGGCGACTACCGAGTCGTGTACACGATCGACAACGGAGAGGTCGTGGTGTGGGTCGTCCATATCGGTCAT
CGCTCCACCGTGTACGACACCTGA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10040.47 Da Isoelectric Point: 5.8235
>AT201734 WP_223525192.1 NZ_CP074169:23720-23992 [Serratia ureilytica]
MTANRTITAPLPAEMAKKVDVWAEKNGRTRSWLVREAVGQFLAREAQRDFLIQEALVAVDLGQVISHEDMVAWAASLGTD
NQQLPPEPRK
MTANRTITAPLPAEMAKKVDVWAEKNGRTRSWLVREAVGQFLAREAQRDFLIQEALVAVDLGQVISHEDMVAWAASLGTD
NQQLPPEPRK
Download Length: 273 bp
>AT201734 NZ_CP098740:2504950-2505219 [Streptomyces drozdowiczii]
ATGACGCAGCCGCAACCCATAGAGTCCATCCGCGCCGTACGCGCGCACCTGGCGGAGGTCGTGGAGCGTGCCGACCGGGA
CGACGTACCCACCGTGATCACCCGACGGGGCAAGCAGGTCGCCGCCATCGTCTCCATCGAGGTGCTGCGCAAGTACCAGG
AGTGGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGTATGGCCGACTCCGCACCCGGCATCCCGATCGAGGACGTC
ATGAGGGAGACGCTGGAACGCGGTGAGTAA
ATGACGCAGCCGCAACCCATAGAGTCCATCCGCGCCGTACGCGCGCACCTGGCGGAGGTCGTGGAGCGTGCCGACCGGGA
CGACGTACCCACCGTGATCACCCGACGGGGCAAGCAGGTCGCCGCCATCGTCTCCATCGAGGTGCTGCGCAAGTACCAGG
AGTGGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGTATGGCCGACTCCGCACCCGGCATCCCGATCGAGGACGTC
ATGAGGGAGACGCTGGAACGCGGTGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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