Detailed information of TA system TA201732

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 4847337..4847872
• Replicon: chromosome
• Accession: NZ_CP074168
• Organism: Serratia ureilytica strain JBIWA004

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A221FWB3
• Locus tag: KGP23_RS23110
• Protein ID: WP_033652296.1
• Coordinates: 4847337..4847612 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8G2GBD7
• Locus tag: KGP23_RS23115
• Protein ID: WP_033639076.1
• Coordinates: 4847612..4847872 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP23_RS23090 (KGP23_23030)	4843227..4843778	+	552	WP_169541158.1	isochorismatase family protein	-
KGP23_RS23095 (KGP23_23035)	4843781..4844704	+	924	WP_101452792.1	DJ-1/PfpI family protein	-
KGP23_RS23100 (KGP23_23040)	4844699..4845691	-	993	WP_197756157.1	acyltransferase	-
KGP23_RS23105 (KGP23_23045)	4845909..4847156	+	1248	WP_033633516.1	MFS transporter	-
KGP23_RS23110 (KGP23_23050)	4847337..4847612	-	276	WP_033652296.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KGP23_RS23115 (KGP23_23055)	4847612..4847872	-	261	WP_033639076.1	ribbon-helix-helix domain-containing protein	Antitoxin
KGP23_RS23120 (KGP23_23060)	4847955..4849796	-	1842	WP_197756156.1	selenocysteine-specific translation elongation factor	-
KGP23_RS23125 (KGP23_23065)	4849793..4851187	-	1395	WP_047025980.1	L-seryl-tRNA(Sec) selenium transferase	-
KGP23_RS23130 (KGP23_23070)	4851257..4851862	-	606	WP_197756155.1	glutathione S-transferase	-
KGP23_RS23135 (KGP23_23075)	4851903..4852553	-	651	WP_033645112.1	DcrB-related protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-43)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10588.36 Da
• Isoelectric Point: 10.3377

>T201732 WP_033652296.1 NZ_CP074168:c4847612-4847337 [Serratia ureilytica]
MELKWTSKALPDLARLFEFLALANRTAAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Nucleotide

• Length: 276 bp

>T201732 NZ_CP098738:522802-523152 [Bacillus halotolerans]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAGATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9682.01 Da
• Isoelectric Point: 4.5317

>AT201732 WP_033639076.1 NZ_CP074168:c4847872-4847612 [Serratia ureilytica]
MNTKVITAHVPLPLAEKVDEMAAKLERSRGWIVKQALAAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDE
PLPVPR

Nucleotide

• Length: 261 bp

>AT201732 NZ_CP098738:522516-522797 [Bacillus halotolerans]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCCTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAACATTTCTTCCGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA

Structures

Toxin

• AlphaFold DB: A0A221FWB3