Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3356096..3356644 Replicon chromosome
Accession NZ_CP074168
Organism Serratia ureilytica strain JBIWA004

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag KGP23_RS15925 Protein ID WP_028127948.1
Coordinates 3356096..3356398 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag KGP23_RS15930 Protein ID WP_025302143.1
Coordinates 3356408..3356644 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP23_RS15905 (KGP23_15850) 3351865..3353022 - 1158 WP_033650593.1 YbfB/YjiJ family MFS transporter -
KGP23_RS15910 (KGP23_15855) 3353128..3354048 + 921 WP_016928453.1 LysR family transcriptional regulator -
KGP23_RS15915 (KGP23_15860) 3354079..3355203 + 1125 WP_223525019.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
KGP23_RS15920 (KGP23_15865) 3355218..3356060 + 843 WP_187048756.1 S-formylglutathione hydrolase -
KGP23_RS15925 (KGP23_15870) 3356096..3356398 - 303 WP_028127948.1 CcdB family protein Toxin
KGP23_RS15930 (KGP23_15875) 3356408..3356644 - 237 WP_025302143.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
KGP23_RS15935 (KGP23_15880) 3356731..3357639 - 909 WP_015377211.1 glutathione ABC transporter permease GsiD -
KGP23_RS15940 (KGP23_15885) 3357649..3358569 - 921 WP_025302141.1 glutathione ABC transporter permease GsiC -
KGP23_RS15945 (KGP23_15890) 3358622..3360157 - 1536 WP_108680364.1 glutathione ABC transporter substrate-binding protein GsiB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-99)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11210.98 Da        Isoelectric Point: 5.0196

>T201729 WP_028127948.1 NZ_CP074168:c3356398-3356096 [Serratia ureilytica]
ITVYDNTYPASAYPYLLDVQSDLIDVLSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQIGKAVG
NVNEHRNQIKAAIDFLIDGF

Download         Length: 303 bp

>T201729 NZ_CP098735:1830018-1831367 [Cupriavidus gilardii]
ATGGGACGGCGATCCCACACCCGTACGCTGACGCTTTGGATGAACGGCGCGTTCGTCGGCACCTGGCATTTCAGTCCGCG
TGCCGGCGATGTGCTGCAGTACGCGCCGGAGTGGGTGGCCTCCGGCGCCGGGCGGCCCTTGTCCCTGTCGCTGCCTTTCA
CTCCGGGCAACGCGCCGCATCGTGGCGACAAGGTGCGGGCCTACTTCGACAATCTGTTGCCGGATACCCGGGAGATTCGT
GAGCGCATTGCCCGGCGGTATCGCACCGGTTCGACCGATGCCTTCGACCTGCTCGCCGAAATCGGCCGCGATTGCGTGGG
CGCGCTGCAACTATTGCCGGACGGCACCGTGCCTGAAGGTGTGCAGCCGGTCGCGGCGGAACCGCTGACCGAGGCTCAGG
TCGCGCAGGTGCTGCGCGGCACGCTGCGATCCGCGCCGCCGGGCTTCGTGGACGAGCAGGACGAGTTCCGTATCTCCATC
GCCGGCGCCCAGGAAAAGACCGCGCTGCTGTACGACAACGGCGCCTGGTGCCTGCCGCACGGCCAAACGCCGACCACCCA
CATCCTGAAGCTGCCGCTTGGCCTCGTCGGCGGGCTGAAGCTGAACATGACCGAATCGGTCGAGAACGAGTGGCTGTGCT
CGCTGATCCTGCGCCAGTTCGGCCTGCCGGTCGCGCACTGCGAACCGGTGCAGTTCGAGGACCTGAAGGCGCTCAGCGTG
CAGCGGTTCGACCGCATGTGGTGGCAAAGTCCGGACGGCGATCGTCGCCTCGTTCGGCTGCCGCAGGAGGACATGTGCCA
GGCCAAGGGCGTGCCGCCGGCGTTCAAGTACGAAGCCGATGGCGGACCCGGCATCGACAGCATCATGGAAACGCTGGCCG
GGTCGACGACGCGCGACGAAGACCGCCGAACGTTCTTCCAGGCACAGGTCCTGTTCTGGATGCTGCGGGCCACCGATGGC
CACGCGAAGAACTTCAGCCTGTTCCTGCGCCCGGAGGGCCGGTATCAGTTGACGCCACTCTACGACGTGCTCTCGGCATA
CCCGATCATCGGGGAGGCGCCGGGCAAGTTGTCGCCGTTCCGGGTCAAGATGGCGATGGCCGTTCGGACGCGAAACGCGC
ACTACCAGATGCGGGAAATCCAGCGCCGCCATTGGCTCGCCGTCGGCGAGCGGCATGGCGTGATCACCGCGGACGGACGT
CCCGCACGGTACGTGCTCGACGATCTGGCCGAACGCGCGCCGCGGGTGGCACAGGCGATACGGGAAGCGCTGCCGAAGAG
CTTCCCGGAGCCGCTGGCCGACTGCATTCTCGATGGAATGCTGGCCGAGGCGGAAAGGCTGGCCGGCTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8967.04 Da        Isoelectric Point: 5.0807

>AT201729 WP_025302143.1 NZ_CP074168:c3356644-3356408 [Serratia ureilytica]
MANSNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Download         Length: 237 bp

>AT201729 NZ_CP098735:1829752-1830015 [Cupriavidus gilardii]
ATGAGCAACTTCACCGTCCGCACCGCCGAGCAACTGCCGCAACTGCTGCAGGCCTTTCGCAAGGAGGCGGGCCTGACGCA
GGCCGAGGCGGCGTTGCGCATGGGAGTCAGCCAACAGACCTTGTCCGCGCTGGAACGCAATCCGGCGCGGGTCAGCGTCG
ACAAGCTGATGCGCGTGCTCAGCGTTCTCGGCGTCGAACTCGTGCTGCACAAGCCGGCTCCCCAACCGCATAACGGCGCG
TCCTCCAGCCCGCAGGTCTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References