Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapD-relB/-
Location 330588..331245 Replicon chromosome
Accession NC_000915
Organism Helicobacter pylori 26695

Toxin (Protein)


Gene name VapD Uniprot ID T5D7N9
Locus tag HP_RS01550 Protein ID WP_000271050.1
Coordinates 330588..330872 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O25085
Locus tag HP_RS01555 Protein ID WP_001134066.1
Coordinates 330853..331245 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP_RS01525 (HP0309) 325790..326668 + 879 WP_000850703.1 carbon-nitrogen hydrolase family protein -
HP_RS01530 (HP0310) 326681..327562 + 882 WP_001040419.1 polysaccharide deacetylase -
HP_RS01535 (HP0311) 327608..327976 + 369 WP_000337920.1 hypothetical protein -
HP_RS01540 (HP0312) 327976..328941 + 966 WP_001124369.1 GTP-binding protein -
HP_RS01545 (HP0313) 328947..330092 - 1146 WP_001263616.1 YbfB/YjiJ family MFS transporter -
HP_RS01550 (HP0315) 330588..330872 - 285 WP_000271050.1 endoribonuclease VapD Toxin
HP_RS01555 (HP0316) 330853..331245 - 393 WP_001134066.1 hypothetical protein Antitoxin
HP_RS01560 (HP0317) 331854..334091 - 2238 WP_000716253.1 outer membrane beta-barrel protein -
HP_RS01565 (HP0318) 334388..335143 - 756 WP_000934548.1 HugZ family heme oxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11188.74 Da        Isoelectric Point: 4.8896

>T20172 WP_000271050.1 NC_000915:c330872-330588 [Helicobacter pylori 26695]
MYALAFDLKIEILKKEYGEPYNKAYDDLRQELELLGFEWTQGSVYVNYSKENTLAQVYKAINKLSQIEWFKKSVRDIRAF
KVEDFSDFTEIVKS

Download         Length: 285 bp

>T20172 NC_000915:c330872-330588 [Helicobacter pylori 26695]
ATGTATGCTTTAGCGTTTGATTTAAAGATTGAGATTTTAAAAAAAGAATACGGAGAACCCTACAATAAAGCCTATGATGA
TTTAAGGCAAGAATTAGAGCTATTAGGGTTTGAATGGACTCAAGGGAGCGTTTATGTTAATTATTCTAAAGAAAACACTC
TAGCACAAGTCTATAAAGCGATCAATAAACTCTCTCAAATTGAGTGGTTTAAAAAGTCTGTTAGGGATATTAGAGCGTTT
AAGGTGGAGGACTTTAGCGATTTTACTGAGATTGTGAAATCCTAG

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15304.38 Da        Isoelectric Point: 7.1101

>AT20172 WP_001134066.1 NC_000915:c331245-330853 [Helicobacter pylori 26695]
MPNTTAKKDYTKYSEKQLFNLIHQLERKIKKMQNDRISFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GHEIPNIETQQAMRDALNGINLTQIDSLDDFTNELKRENSKGFENVCFSV

Download         Length: 393 bp

>AT20172 NC_000915:c331245-330853 [Helicobacter pylori 26695]
ATGCCTAACACCACCGCCAAAAAAGACTACACAAAATACAGCGAAAAACAGCTTTTTAATTTAATCCATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAATTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCGTTAAATGAACTCTTGCAAAAAATCAGTCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCATGAGATCCCAAACATTGAAACGCAACAAGCCATGAGAGATGCGTTAAATGGAATTAATCTCACTCAAATTGATAG
TTTAGATGATTTTACAAACGAGTTAAAAAGAGAAAATAGTAAAGGTTTTGAAAATGTATGCTTTAGCGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3UI3

Antitoxin

Source ID Structure
AlphaFold DB A0A1Y3E322

References