Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 771656..772325 Replicon chromosome
Accession NZ_CP074168
Organism Serratia ureilytica strain JBIWA004

Toxin (Protein)


Gene name cptA Uniprot ID A0A8B4GZI3
Locus tag KGP23_RS03605 Protein ID WP_042785308.1
Coordinates 771903..772325 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8B4GS04
Locus tag KGP23_RS03600 Protein ID WP_019455657.1
Coordinates 771656..771922 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP23_RS03575 (KGP23_03565) 767223..768149 + 927 WP_033644768.1 ribokinase -
KGP23_RS03580 (KGP23_03570) 768190..768798 - 609 WP_033644771.1 HD domain-containing protein -
KGP23_RS03585 (KGP23_03575) 768982..769656 + 675 WP_033644772.1 hemolysin III family protein -
KGP23_RS03590 (KGP23_03580) 769807..770304 + 498 WP_033644774.1 DUF2165 domain-containing protein -
KGP23_RS03595 (KGP23_03585) 770343..771335 - 993 WP_047573794.1 tRNA-modifying protein YgfZ -
KGP23_RS03600 (KGP23_03590) 771656..771922 + 267 WP_019455657.1 FAD assembly factor SdhE Antitoxin
KGP23_RS03605 (KGP23_03595) 771903..772325 + 423 WP_042785308.1 protein YgfX Toxin
KGP23_RS03610 (KGP23_03600) 772391..772909 - 519 WP_033635825.1 flavodoxin FldB -
KGP23_RS03615 (KGP23_03605) 773016..773915 + 900 WP_033644935.1 site-specific tyrosine recombinase XerD -
KGP23_RS03620 (KGP23_03610) 773942..774658 + 717 WP_042785306.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KGP23_RS03625 (KGP23_03615) 774665..776398 + 1734 WP_072627049.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16527.59 Da        Isoelectric Point: 10.8114

>T201718 WP_042785308.1 NZ_CP074168:771903-772325 [Serratia ureilytica]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGLLLTLQPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEQD

Download         Length: 423 bp

>T201718 NZ_CP098727:120937-121089 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10417.91 Da        Isoelectric Point: 4.7921

>AT201718 WP_019455657.1 NZ_CP074168:771656-771922 [Serratia ureilytica]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT201718 NZ_CP098727:120313-120912 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGGGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATATTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GS04

References