Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3977668..3978467 Replicon chromosome
Accession NZ_CP074159
Organism Enterobacter sp. JBIWA005

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag KGP22_RS18870 Protein ID WP_123060711.1
Coordinates 3978090..3978467 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag KGP22_RS18865 Protein ID WP_123060710.1
Coordinates 3977668..3978033 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP22_RS18820 (KGP22_18720) 3973073..3973480 + 408 WP_032233521.1 hypothetical protein -
KGP22_RS18825 (KGP22_18725) 3973552..3973779 + 228 WP_123060703.1 hypothetical protein -
KGP22_RS18830 (KGP22_18730) 3974082..3974918 + 837 WP_123060705.1 hypothetical protein -
KGP22_RS18835 (KGP22_18735) 3975012..3975245 + 234 WP_123060706.1 DUF905 domain-containing protein -
KGP22_RS18840 (KGP22_18740) 3975349..3976167 + 819 WP_143345534.1 DUF932 domain-containing protein -
KGP22_RS18845 (KGP22_18745) 3976167..3976421 + 255 WP_123060707.1 hypothetical protein -
KGP22_RS18850 (KGP22_18750) 3976509..3976919 + 411 Protein_3675 antirestriction protein -
KGP22_RS18855 (KGP22_18755) 3976931..3977395 + 465 WP_123060708.1 DNA repair protein RadC -
KGP22_RS18860 (KGP22_18760) 3977424..3977645 + 222 WP_123060709.1 DUF987 domain-containing protein -
KGP22_RS18865 (KGP22_18765) 3977668..3978033 + 366 WP_123060710.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KGP22_RS18870 (KGP22_18770) 3978090..3978467 + 378 WP_123060711.1 TA system toxin CbtA family protein Toxin
KGP22_RS18875 (KGP22_18775) 3978464..3978916 + 453 WP_143345536.1 DUF5983 family protein -
KGP22_RS18880 (KGP22_18780) 3978985..3979188 + 204 WP_123060713.1 DUF957 domain-containing protein -
KGP22_RS18885 (KGP22_18785) 3979270..3980112 + 843 WP_123060714.1 DUF4942 domain-containing protein -
KGP22_RS18890 (KGP22_18790) 3980387..3980809 - 423 WP_223580486.1 hypothetical protein -
KGP22_RS18895 (KGP22_18795) 3981071..3981598 - 528 WP_149367683.1 LuxR C-terminal-related transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3934684..3980779 46095


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13754.84 Da        Isoelectric Point: 9.9983

>T201707 WP_123060711.1 NZ_CP074159:3978090-3978467 [Enterobacter sp. JBIWA005]
MQTLSAIPARKAPSHPTPVEIWQRLLTYLLERHYGLSLNDTQFGNDGVIQQHIDAGLSLADALNFLVEKSELVRIDRPGF
SIQHQSPFISAIDILRARKAIGLMQRTGYKAVTCAISGRSSGGLK

Download         Length: 378 bp

>T201707 NZ_CP098723:c3136917-3135967 [Yersinia ruckeri]
ATGGATGATTTAACAAAGCTATTCCCAGATGTTGCTGATGCTCTGGGCATTGAATCTGTTTCAATTGTAGAAAAAGATTA
TTACATCGTTGAGTTATTACGATTGCTCCAGCCTCTGGACTTTGACACGCATCAGCTGGTTTTTGCCGGTGGAACAGCAT
TGTCAAAAGCGGGTATATCTTTGAACAGGATGTCGGAAGACGTGGACATTAAGCTTGTCCCCGTCGCTGGTTTTACCCAG
CAATATTCCAGAGGCCAGCGTAAAGACATTCGTAAGGGTATTATTCGGACCGTTATCGAAACGATTACAGCTTCAGGTAC
GTTTCGCATGGATGAAGGGTATCCAAAGGTTACTCGTGATGAATATCGCTATAATGAAATTCCGGTGCGTTACCCGCAGG
AATATGTACAAGTTCCCTGCTTAAGGCCATTTATCAAACTGGAACTGATGGAAACGGATTTGCTTGAGGCTGCGGAAAAT
CGTGCTATTAGCTCCTTGGTAATGGATCTAACAAAGAAGGGCGAAGTAGTGAGGGCTTTCCCTTGCGCAACCATCGGTAG
CACGCAGGCTGAAAAACTGATCTCGATGATGCGCAGAACGGCTGCAAGTATGCGTGATGTGGAACGTGCAGTGGATGAAT
CACTGGTACGTCATATCTACGATAATTTTTGTATTGTTAGAGAAAAAGGTGCTGACGTTCCTGTTTTGAAGCAATTCGTG
CAGGAATGCATTGAACAGGATATTGAACGTTACGGTGCTCAGTACCCTGAATTCTGCGAGTCGCCTGTCGAAGAACTAAA
AATGGGGCTGGAAGAACTCGTGAGCAATCCTGTTTATAAGGAACGCTATCTGCAATTCGTCACACCAATGGTCTTCGGTG
AAAGCCACGTTTCATGGGAAGAGGCCTATGCCTGTTTTCGCAAAACGGTATTGGATGTGGTTGATGCATAG

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13398.24 Da        Isoelectric Point: 5.9501

>AT201707 WP_123060710.1 NZ_CP074159:3977668-3978033 [Enterobacter sp. JBIWA005]
MPNTTPVANHDISEPWWGLKPTVTPCFGARLVQEGNHLHYLADRSTIEGTFSDADLRHLDQAFPVLMKQLELMLVSGELN
PRNQHCVTLYAKGLTLDADTLGSCGYLYIAIYPTSGNSIPR

Download         Length: 366 bp

>AT201707 NZ_CP098723:c3137305-3136910 [Yersinia ruckeri]
ATGACTACAAAAGCTCGTATTCAGTTACGACTGAAACGCTCAAAGCGTTATGTTTTCACTCGTGACGATTTCAAAGATCT
TGCTGGCTACGACCAAATTGGTAGAGCACTGCGTGAACTGGTGAAGGAAGGGCAGCTGCTGAAAGTAGGCTATGGCGTCT
ACACCAAAGCGCGGCAAAATGTGATTACCGGTAAGTTGATGCCTGCGGCTCCTGGAGGTTCGGCTGCGGTAGTGATTGAG
GCGTTGGAACGTCTGAAAGTGGATTACCGCTTGGTTGGAGCAACAAGCGCCTATAATAGCGGTAAATCCACTCAGATCCC
CGCTTCACTGGAAATCAAAACCTCACCACGTTTTAAGAGGACATTGTCAGTAGGGAGCAGCAAACTAAATGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References