Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3866439..3867096 Replicon chromosome
Accession NZ_CP074159
Organism Enterobacter sp. JBIWA005

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag KGP22_RS18265 Protein ID WP_021242050.1
Coordinates 3866439..3866849 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag KGP22_RS18270 Protein ID WP_006178375.1
Coordinates 3866830..3867096 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP22_RS18245 (KGP22_18150) 3862432..3864165 - 1734 WP_223580461.1 single-stranded-DNA-specific exonuclease RecJ -
KGP22_RS18250 (KGP22_18155) 3864171..3864884 - 714 WP_149367671.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KGP22_RS18255 (KGP22_18160) 3864913..3865809 - 897 WP_111963202.1 site-specific tyrosine recombinase XerD -
KGP22_RS18260 (KGP22_18165) 3865911..3866432 + 522 WP_008499710.1 flavodoxin FldB -
KGP22_RS18265 (KGP22_18170) 3866439..3866849 - 411 WP_021242050.1 protein YgfX Toxin
KGP22_RS18270 (KGP22_18175) 3866830..3867096 - 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
KGP22_RS18275 (KGP22_18180) 3867391..3868371 + 981 WP_223580462.1 tRNA-modifying protein YgfZ -
KGP22_RS18280 (KGP22_18185) 3868482..3869141 - 660 WP_127732244.1 hemolysin III family protein -
KGP22_RS18285 (KGP22_18190) 3869307..3869618 - 312 WP_223582476.1 N(4)-acetylcytidine aminohydrolase -
KGP22_RS18290 (KGP22_18195) 3869670..3870401 + 732 WP_223582479.1 MurR/RpiR family transcriptional regulator -
KGP22_RS18295 (KGP22_18200) 3870518..3871951 + 1434 WP_223580463.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T201706 WP_021242050.1 NZ_CP074159:c3866849-3866439 [Enterobacter sp. JBIWA005]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T201706 NZ_CP098723:2692226-2692429 [Yersinia ruckeri]
ATGACCAAAACTGACTACCTAATGCGTTTAAGAAAATGCACAACAATTGACACACTAGAGCGTGTTATTGAAAAAAATAA
GTATGAGCTATCTGATGATGAACTAGAGTTATTCTATTCTGCTGCGGATCATCGTCTAGCTGAACTTACCATGAATAAGT
TATACGATAAAATTCCTGCAACTGTCTGGCAACATGTGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT201706 WP_006178375.1 NZ_CP074159:c3867096-3866830 [Enterobacter sp. JBIWA005]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT201706 NZ_CP098723:2691806-2692174 [Yersinia ruckeri]
ATGGATGAGTACTCACCTAAGCGACATGATATTGCTCAGTTGAAATTCTTATGTGAGAATTTGTATGATGAAGGTATCGC
CACATTGGGCGATAGCCACCACGGCTGGGTTAATGATCCAACCTCCGCGGTAAATCTCCAACTGAATGATTTAATCGAAC
ACATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACGCAGACGAAATCGATCTCTGCGAGTTGGTGGAGGAATATCTA
GACGATACATATACCTTGTTCAGCAGTTACGGAATCAATGATCCTGATTTACGCCGCTGGCAGAAAACAAAAGACCGATT
ATTCAGACTATTTTCAGGGGAATACCTATGTGCCCTGATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References