201695

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1083149..1083769 Replicon chromosome
Accession NZ_CP074159
Organism Enterobacter sp. JBIWA005

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag KGP22_RS05115 Protein ID WP_008499287.1
Coordinates 1083149..1083367 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag KGP22_RS05120 Protein ID WP_008499288.1
Coordinates 1083395..1083769 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP22_RS05085 (KGP22_05055) 1079167..1079427 + 261 WP_010428154.1 type B 50S ribosomal protein L31 -
KGP22_RS05090 (KGP22_05060) 1079430..1079570 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
KGP22_RS05095 (KGP22_05065) 1079567..1080277 - 711 WP_115874370.1 GNAT family protein -
KGP22_RS05100 (KGP22_05070) 1080379..1081836 + 1458 WP_223581456.1 PLP-dependent aminotransferase family protein -
KGP22_RS05105 (KGP22_05075) 1081808..1082275 - 468 WP_023310598.1 YlaC family protein -
KGP22_RS05110 (KGP22_05080) 1082393..1082944 - 552 WP_111963392.1 maltose O-acetyltransferase -
KGP22_RS05115 (KGP22_05085) 1083149..1083367 - 219 WP_008499287.1 HHA domain-containing protein Toxin
KGP22_RS05120 (KGP22_05090) 1083395..1083769 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
KGP22_RS05125 (KGP22_05095) 1084280..1087426 - 3147 WP_029741964.1 multidrug efflux RND transporter permease subunit AcrB -
KGP22_RS05130 (KGP22_05100) 1087449..1088642 - 1194 WP_023310601.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - acrB / acrA 1083149..1093075 9926


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T201695 WP_008499287.1 NZ_CP074159:c1083367-1083149 [Enterobacter sp. JBIWA005]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T201695 NZ_CP098719:c2274613-2274520 [Yersinia ruckeri]
TAAGCCTGCATGAAATGCCAACTTTTAGCGCACGGCTCTATCCCAAGAGCCATTTCCCTGGACCGAATATAGGATTCGTA
TTCGGTCTTTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT201695 WP_008499288.1 NZ_CP074159:c1083769-1083395 [Enterobacter sp. JBIWA005]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT201695 NZ_CP098719:2274516-2274662 [Yersinia ruckeri]
AGATAAAAAAAGACCGAATACGAATCCTATATTCGGTCCAGGGAAATGGCTCTTGGGATAGAGCCGTGCGCTAAAAGTTG
GCATTTCATGCAGGCTTATTAAGCCGTACCACTTAAGCGTAGTAGACGACCCACATTTTACCAATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References