Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1663614..1664204 Replicon chromosome
Accession NZ_CP074154
Organism Enterobacter asburiae strain JBIWA007

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag KGP18_RS08025 Protein ID WP_064672767.1
Coordinates 1663872..1664204 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag KGP18_RS08020 Protein ID WP_223536856.1
Coordinates 1663614..1663871 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP18_RS07990 (KGP18_07995) 1659286..1659894 - 609 WP_223536842.1 glutathione S-transferase family protein -
KGP18_RS07995 (KGP18_08000) 1660065..1660958 + 894 WP_223536845.1 LysR substrate-binding domain-containing protein -
KGP18_RS08000 (KGP18_08005) 1661136..1661510 + 375 WP_223536848.1 type II toxin-antitoxin system RelE/ParE family toxin -
KGP18_RS08005 (KGP18_08010) 1661494..1661796 + 303 WP_029741460.1 XRE family transcriptional regulator -
KGP18_RS08010 (KGP18_08015) 1661871..1662791 - 921 WP_223536851.1 LysR family transcriptional regulator -
KGP18_RS08015 (KGP18_08020) 1662933..1663322 + 390 WP_223536853.1 RidA family protein -
KGP18_RS08020 (KGP18_08025) 1663614..1663871 + 258 WP_223536856.1 antitoxin Antitoxin
KGP18_RS08025 (KGP18_08030) 1663872..1664204 + 333 WP_064672767.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KGP18_RS08035 (KGP18_08040) 1664499..1666688 - 2190 WP_223536859.1 TonB-dependent siderophore receptor -
KGP18_RS08040 (KGP18_08045) 1666715..1668040 - 1326 WP_223536861.1 SidA/IucD/PvdA family monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1652594..1664204 11610


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11798.63 Da        Isoelectric Point: 9.4051

>T201681 WP_064672767.1 NZ_CP074154:1663872-1664204 [Enterobacter asburiae]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEGAGTTTTGVIRCDQPRTI
DMAARNGMRLERIPDAVVNEVLARLDAILN

Download         Length: 333 bp

>T201681 NZ_CP098714:c3070409-3069987 [Yersinia ruckeri]
GTGGCCCAGTGGCGATGTGATCTGCGGGTTTCATGGCGCACCCAACTTTTCTCACTATTGGTACACGGTGTTCTGGTATT
ACTGACACTGGTGGTACCTTGGCCTGACGGATTTACTCCGCTATGGCTTATATTGCTGACGCTGGTGGTGTTTGAATGCA
TTCGCAGCCAGAAGAACATTACCTCTCGACAGGGAGAGATCCGGCTTAAAGCGGGAAATCTGTTGATTTGGAAGTGGCAA
GAGTGGACGTTGGTGCGGCCGCCGTGGATTACCCGCTACGGCGTATTATTATCGTTACAAGGCGCTGGCAGCCGCCGCCG
AAAACGTATTTGGCTAGCCTCCGACAGCATGTCGGAAGAAAAATGGCGCGAGTTGTGTCTGATATTACGACATACTTTTG
ATTCTGCGGCAGGCCGTGAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9494.95 Da        Isoelectric Point: 4.4737

>AT201681 WP_223536856.1 NZ_CP074154:1663614-1663871 [Enterobacter asburiae]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTINNGCLIIEPQKRPHYSLEELLTQCDPHAEMSEEEREWIDAPAV
GREIL

Download         Length: 258 bp

>AT201681 NZ_CP098714:c3070656-3070390 [Yersinia ruckeri]
ATGGAAATTGATAACAAAGCCCGAATCCATTGGGCATGCCGCCGGGGTATGCGTGAACTGGATATCTCCATAATGCCATT
TTTCGAACATGAATATGACACGCTAAACGATAATGATAAGCGCGTATTTATCCGCTTGCTGACGAGTGATGATCCTGATT
TATTCAATTGGTTGATGAACCACGGCGAGCCGCAGGATAGCGAACTGAAACGAATGGTTAAACTGATTCAGACACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References