Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 816408..817147 Replicon chromosome
Accession NZ_CP074154
Organism Enterobacter asburiae strain JBIWA007

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag KGP18_RS04055 Protein ID WP_063439899.1
Coordinates 816662..817147 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A157GCY0
Locus tag KGP18_RS04050 Protein ID WP_029739941.1
Coordinates 816408..816674 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP18_RS04025 (KGP18_04025) 811778..812876 + 1099 WP_096151315.1 peptide chain release factor 2 -
KGP18_RS04030 (KGP18_04030) 812886..814403 + 1518 WP_023309094.1 lysine--tRNA ligase -
KGP18_RS04035 (KGP18_04035) 814443..814985 - 543 WP_205915978.1 isopentenyl-diphosphate Delta-isomerase -
KGP18_RS04040 (KGP18_04040) 815149..815892 + 744 WP_223536017.1 amidase activator ActS -
KGP18_RS04050 (KGP18_04050) 816408..816674 + 267 WP_029739941.1 DUF1778 domain-containing protein Antitoxin
KGP18_RS04055 (KGP18_04055) 816662..817147 + 486 WP_063439899.1 GNAT family N-acetyltransferase Toxin
KGP18_RS04060 (KGP18_04060) 817435..817525 - 91 Protein_788 hypothetical protein -
KGP18_RS04065 (KGP18_04065) 817845..819164 + 1320 WP_223536019.1 GTPase-associated system all-helical protein GASH -
KGP18_RS04070 (KGP18_04070) 819266..820117 + 852 WP_223536022.1 GTPase domain-containing protein -
KGP18_RS04075 (KGP18_04075) 820120..820953 + 834 WP_223536024.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 816408..825336 8928


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17592.30 Da        Isoelectric Point: 9.5811

>T201679 WP_063439899.1 NZ_CP074154:816662-817147 [Enterobacter asburiae]
VGRVTAPEPLSSSHQLAEFVSGEAVLDDWLKQRGLKNQALGAARTFVVCKTDTKQVAGFYSLATGSVNHVEATGSLRRNM
PDPIPVIILARLAVDVSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKSFYLHHGFKASQIQERTLFLKLP
Q

Download         Length: 486 bp

>T201679 NZ_CP098714:c2107755-2107662 [Yersinia ruckeri]
TAAGCCTGCATGAAATGCCAACTTTTAGCGCACGGCTCTATCCCAAGAGCCATTTCCCTGGACCGAATATAGGATTCGTA
TTCGGTCTTTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10038.42 Da        Isoelectric Point: 4.4733

>AT201679 WP_029739941.1 NZ_CP074154:816408-816674 [Enterobacter asburiae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVTDDATIGKLL
GRKPQWDV

Download         Length: 267 bp

>AT201679 NZ_CP098714:2107658-2107804 [Yersinia ruckeri]
AGATAAAAAAAGACCGAATACGAATCCTATATTCGGTCCAGGGAAATGGCTCTTGGGATAGAGCCGTGCGCTAAAAGTTG
GCATTTCATGCAGGCTTATTAAGCCGTACCACTTAAGCGTAGTAGACGACCCACATTTTACCAATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A157GCY0

References