Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 807023..807680 Replicon chromosome
Accession NZ_CP074154
Organism Enterobacter asburiae strain JBIWA007

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag KGP18_RS04000 Protein ID WP_021242050.1
Coordinates 807270..807680 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag KGP18_RS03995 Protein ID WP_010435322.1
Coordinates 807023..807289 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP18_RS03970 (KGP18_03970) 802204..803637 - 1434 WP_033146593.1 6-phospho-beta-glucosidase BglA -
KGP18_RS03975 (KGP18_03975) 803754..804485 - 732 WP_223537810.1 MurR/RpiR family transcriptional regulator -
KGP18_RS03980 (KGP18_03980) 804537..804848 + 312 WP_223536012.1 N(4)-acetylcytidine aminohydrolase -
KGP18_RS03985 (KGP18_03985) 805014..805673 + 660 WP_063439895.1 hemolysin III family protein -
KGP18_RS03990 (KGP18_03990) 805748..806728 - 981 WP_223536014.1 tRNA-modifying protein YgfZ -
KGP18_RS03995 (KGP18_03995) 807023..807289 + 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
KGP18_RS04000 (KGP18_04000) 807270..807680 + 411 WP_021242050.1 protein YgfX Toxin
KGP18_RS04005 (KGP18_04005) 807687..808208 - 522 WP_223536016.1 flavodoxin FldB -
KGP18_RS04010 (KGP18_04010) 808310..809206 + 897 WP_023309098.1 site-specific tyrosine recombinase XerD -
KGP18_RS04015 (KGP18_04015) 809235..809948 + 714 WP_023309097.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KGP18_RS04020 (KGP18_04020) 809954..811687 + 1734 WP_109844606.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T201678 WP_021242050.1 NZ_CP074154:807270-807680 [Enterobacter asburiae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T201678 NZ_CP098714:1877672-1878130 [Yersinia ruckeri]
GTGATGCTCTACCGGATAGTTCACAACCGTTACCTGGCAACGGCCTGGACCGGATATGGCGCAGAAACCTATGGTGGCCG
CTGGAATCATAAAGGCCATGCGGCGATTTATCTGGCCAGTAGCGTTTCTCTGGCGATGCTCGAAACACTGGTGCATGTAG
AAGATAGCGCGACGCTGAACGATTTTAATCTATTTCAGATAACCATTCCCGATAATGCAATTATGGTACTGCAACAGCAA
GATTGGCCACGTGGATGGCGAGATGACCCCACCCCCGTGGCCACCATGGACATCGGCACCGAATGGATTGGTTCAGTATC
ATCTGTCGGTCTGCTGGTACCATCCACGTTAGTCCCTTTGGAAAGAAATATGCTGGTGAATCCTAAACACCGCGATTTCG
CCTCGTGCCTGAAAAGCATCAATCCACTGACGTTCAGTTTTGATCCTCGTCTAAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT201678 WP_010435322.1 NZ_CP074154:807023-807289 [Enterobacter asburiae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT201678 NZ_CP098714:1877212-1877658 [Yersinia ruckeri]
ATGAGAACTTATCACCCAAGCCCGATGGCCAAAGTCAGCGCACTATGGCGTGAGATTGGTCTACCCGCCAGTCGTGGCAC
CGCTTTGGTGGACAGCATAAAACTGGGATTTACTGTGGATGTGATCGACACTATACATTTATGGGCTGATATGCCTAAAT
CTGAAATATTACGCGCTACGGGCATTCCGAGCCGCAGTCTGACGCGCCGTCGTACCCATGATGGGCGTTTTACCCCGGAA
GAAAGCGAACGTATTGCACGGTTTGTCCGGGTTATGGATGCGGCGGTAGATTTGTTCGGTGGTGACCGCACCAAAGCAAC
CGCATGGATGTCGATGCCGGTCAAAGGGCTGGGTAATCGAACGCCCGATTCACTGCTGGAAACCGAAACCGGTGCGTTGG
AAATCTGCGACCTGATTGGTCGTCTCGAACATGGGGTCTTTTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References