Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 624684..625478 Replicon chromosome
Accession NZ_CP074149
Organism Enterobacter sp. JBIWA008

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag KGP24_RS02975 Protein ID WP_194400898.1
Coordinates 624684..625205 (-) Length 174 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A156QBZ1
Locus tag KGP24_RS02980 Protein ID WP_063143245.1
Coordinates 625209..625478 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP24_RS02950 (KGP24_02945) 620056..620217 + 162 WP_032645487.1 DUF1127 domain-containing protein -
KGP24_RS02955 (KGP24_02950) 620257..621645 - 1389 WP_223562316.1 PLP-dependent aminotransferase family protein -
KGP24_RS02960 (KGP24_02955) 621749..622228 + 480 WP_014882392.1 carboxymuconolactone decarboxylase family protein -
KGP24_RS02965 (KGP24_02960) 622215..623117 - 903 WP_223562317.1 LysR family transcriptional regulator -
KGP24_RS02970 (KGP24_02965) 623218..624633 + 1416 WP_223562318.1 aldehyde dehydrogenase family protein -
KGP24_RS02975 (KGP24_02970) 624684..625205 - 522 WP_194400898.1 GNAT family N-acetyltransferase Toxin
KGP24_RS02980 (KGP24_02975) 625209..625478 - 270 WP_063143245.1 DUF1778 domain-containing protein Antitoxin
KGP24_RS02985 (KGP24_02980) 625721..625840 + 120 Protein_579 transcriptional regulator -
KGP24_RS02990 (KGP24_02985) 626091..626561 + 471 WP_194400897.1 MarR family transcriptional regulator -
KGP24_RS02995 (KGP24_02990) 626558..627625 + 1068 WP_223563444.1 HlyD family secretion protein -
KGP24_RS03000 (KGP24_02995) 627615..628691 + 1077 WP_223562319.1 DUF2955 domain-containing protein -
KGP24_RS03005 (KGP24_03000) 628688..629959 - 1272 WP_223562320.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(3-85)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19790.88 Da        Isoelectric Point: 8.4279

>T201664 WP_194400898.1 NZ_CP074149:c625205-624684 [Enterobacter sp. JBIWA008]
VNDVKIGIFSEDVEYDLSQFDCGEESLNTFLAEHLKRQHRGKFLRGYVLTTREPKPRILGYYTLSGSCFEKAYLPSKTQQ
KRIPYKNVPSVTLGRLAIDKRIQGQGYGELLVIHAMKTVYLASFAVGIHGLFVEALNHKAKEFYLKMGFIPLLAENEFTL
FLPTKTFESVFEE

Download         Length: 522 bp

>T201664 NZ_CP098710:c1969669-1969576 [Yersinia ruckeri]
TAAGCCTGCATGAAATGCCAACTTTTAGCGCACGGCTCTATCCCAAGAGCCATTTCCCTGGACCGAATATAGGATTCGTA
TTCGGTCTTTTTTT

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10071.49 Da        Isoelectric Point: 5.8508

>AT201664 WP_063143245.1 NZ_CP074149:c625478-625209 [Enterobacter sp. JBIWA008]
MSALKKQRIDLRLTEDDKNMIEEAAAMTNQSISQFMVSTASERAAEVIDQHRRLVLSEASWNTVMDAISNPPAPNDRLKR
AAKRLLDME

Download         Length: 270 bp

>AT201664 NZ_CP098710:1969572-1969718 [Yersinia ruckeri]
AGTTAAAAAAAGACCGAATACGAATCCTATATTCGGTCCAGGGAAATGGCTCTTGGGATAGAGCCGTGCGCTAAAAGTTG
GCATTTCATGCAGGCTTATTAAGCCGTACCACTTAAGCGTAGTAGACGACCCACATTTTACCAATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A156QBZ1

References