Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 5881852..5883431 Replicon chromosome
Accession NZ_CP074147
Organism Serratia sp. JSRIV001

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag KGP17_RS27285 Protein ID WP_223498648.1
Coordinates 5881852..5883171 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag KGP17_RS27290 Protein ID WP_059199269.1
Coordinates 5883171..5883431 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP17_RS27265 (KGP17_27175) 5877569..5878906 + 1338 WP_021181404.1 NCS2 family permease -
KGP17_RS27270 (KGP17_27180) 5878961..5880013 - 1053 WP_094982464.1 hypothetical protein -
KGP17_RS27275 (KGP17_27185) 5880106..5880672 - 567 WP_021181402.1 NADPH-dependent FMN reductase -
KGP17_RS27280 (KGP17_27190) 5880861..5881580 - 720 WP_094982465.1 4'-phosphopantetheinyl transferase superfamily protein -
KGP17_RS27285 (KGP17_27195) 5881852..5883171 - 1320 WP_223498648.1 type II toxin-antitoxin system HipA family toxin Toxin
KGP17_RS27290 (KGP17_27200) 5883171..5883431 - 261 WP_059199269.1 helix-turn-helix domain-containing protein Antitoxin
KGP17_RS27295 (KGP17_27205) 5883742..5885106 - 1365 WP_021181398.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
KGP17_RS27300 (KGP17_27210) 5885220..5886860 - 1641 WP_021181397.1 membrane protein insertase YidC -
KGP17_RS27305 (KGP17_27215) 5886863..5887120 - 258 WP_025120915.1 membrane protein insertion efficiency factor YidD -
KGP17_RS27310 (KGP17_27220) 5887084..5887443 - 360 WP_004950547.1 ribonuclease P protein component -
KGP17_RS27315 (KGP17_27225) 5887462..5887602 - 141 WP_004093983.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 48759.10 Da        Isoelectric Point: 7.4430

>T201660 WP_223498648.1 NZ_CP074147:c5883171-5881852 [Serratia sp. JSRIV001]
MADLDVYMNGYKVGIFSREGTGAHMFQYVDTWLNQPGSRPISLSMPLRRRPYKGAEVYNFFDNLLPDNPEIRGRILARYR
ADSTQPFDLLARIGADTIGALQLLPQNAGPGDIRTINYKALSNQELASILTGYKAGAPLGMIEDVEDFRISLAGAQEKTA
LLYLENRWCLPIAATPTTHIIKLPIGKIESHSNSIDLSDSVENEYLCALVAKEFGLSVPHCFIMQVGDIKALAVERFDRR
YASDGSWIMRLPQEDFCQVLNVPSARKYENQGGPGISEIMEYLLGSVTAEKDRYNFMKAQVLFWLLAATDGHAKNFSVFI
EADGRFRLTPLYDILSVYPVFAGRGLHPKDAKLAMGLKGSKGKKYAIEQIFPRHFFHTAKAVGFERAAMEGILTELAESV
DTVIERVTQLLPAGFPPAISNAILKGLKARSARLTVGWD

Download         Length: 1320 bp

>T201660 NZ_CP098710:472946-473602 [Yersinia ruckeri]
GTGGCCTATGACTACAGCACTAGCCTCAACCCGGAAAAAGCCTTGATCTGGCGCATTGTCCATCGGGACAATATTCCGTG
GATACTGGACAACGGTCTGCACTGTGGCAACAGTCCGGTGCAGGCGGAAGACTGGATTAATATCGGTAACCCGGAGCTTA
TCGACAAACGTGCCGGACATCTGGTGCCAACCGGAATGCGGGGGACGCTGCATGACTATGTGCCGTTTTACTTTACTCCT
TTCTCGCCGATGCTGATGAATATCCGCAGCGGACGTGGCGGCATTAAGCAACGCCCCAATGAGGAGATCGTTATTCTGGT
CAGTAGCCTGCGAAACATGGTGGCGCAAAATGTCTCCTTCGTGTTTACCGATAGCCACGCATATTATAACCTGGCTAATT
ACTTTACCGAGCTGGACAGTCTGAACCAGATCGATTGGCCCATTCTACAAGCGCGGGATTTCCGTCGCGATCAGGACGAT
TTGGCCAAGTTCGAACGCTATCAGGCAGAGGCGTTAATTTGGAAGCACTGCCCAATAGCGCTGCTTGGCGGGATGATTTG
TTACAACGATGGCGTCAGGTTACAATTAGAGCAGTGGTTGTCGCAACGCAATCTGTCAATGCCCGTTCACGCGCGGGCTG
GGTGGTACTTCTCATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9832.18 Da        Isoelectric Point: 6.3263

>AT201660 WP_059199269.1 NZ_CP074147:c5883431-5883171 [Serratia sp. JSRIV001]
MKITNAKQLSIYLRDVRLAENLSQEKVASRVGIRQDTVSNFELQPGTTKLETFFKILSALDLELEVKPRGSQSCETKSTD
GWKEEW

Download         Length: 261 bp

>AT201660 NZ_CP098710:473599-474666 [Yersinia ruckeri]
ATGATTACATTTACACAAGGCAATTTACTGGATGCGCCCGTAGAAGCACTAGTGAATACGGTTAATACCGTCGGTGTCAT
GGGTAAAGGCATCGCGCTGATGTTCAAAGAGCGCTTCCCCGTCAATATGAAAGCCTATGCTCTCGCCTGCAAACATAAGC
AGGTAATGACAGGTAAAATGTTTATTACCGAAACCGGCGAACTGATGGGGCCTCGCTGGATTGTCAACTTCCCAACTAAA
CAACACTGGCGCGCAGACTCCCGCATGGAGTGGGTTGAAGACGGCTTGCAGGATTTACGCCGCTTTTTGATCGAAGAGAA
AGTGCAATCTATCGCCATTCCCCCACTGGGGGCGGGTAACGGCGGCCTGAATTGGTCGGACGTTCGGATGCGGATTGAAT
CTGCGCTGGGCGACCTTCAGGACACGGAAATTCTGATTTATGAGCCTACCGAAAAATACCAGAACGTCGCCAAGAGCACC
GGCGTAAAAAAGCTCACTCCCGCCAGAGCGCTGATTGCTGAACTGGTGCGCCGCTACTGGGTGCTGGGCATGGAGTGCAG
CCTGCTGGAAATCCAGAAGCTGGCATGGCTGTTACAACGCGCCATTGAACAGCATCAGCAGGAAGATGTGCTGAAACTGC
GGTTTGAGGCGCACTATTACGGCCCCTACGCCCCCAACCTTAACCATCTGCTTAACGCGCTAGATGGCACGTATCTGAAA
GCAGAGAAACGCATCCCGGACACCCAGCCGCTGGATGTGATCTGGTTTAATGATCAGGAAAAAGAACACATCAACCTCTG
GCTGAACAACGAGGCCAAAGAGTGGCTACCGGCGCTTGAGCAGGTCAGTCAGTTGATTGACGGCTTTGAATCGCCGTTTG
GTCTGGAGCTGCTGGCAACCGTTGACTGGCTGCTGACCCGAGGAAAATGCCAGCCCACGCTGGATTCCGTGAAAGAGGGG
CTGCACCAGTGGCCTGCGGGTGAACGCTGGGCCAGCCGTAAGATGAAGCTCTTTGACGACAAGAATCTGCAATTTGCCAT
CAACCGCGTGATGGAGTTCCATTGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References