Detailed information of TA system TA201657

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 5000088..5000643
• Replicon: chromosome
• Accession: NZ_CP074147
• Organism: Serratia sp. JSRIV001

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KGP17_RS27900
• Protein ID: WP_245398320.1
• Coordinates: 5000509..5000643 (+)
• Length: 45 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KGP17_RS23255
• Protein ID: WP_223498456.1
• Coordinates: 5000088..5000369 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP17_RS23210 (KGP17_23125)	4995385..4995837	+	453	WP_223498447.1	hypothetical protein	-
KGP17_RS23215 (KGP17_23130)	4995834..4996286	+	453	WP_223498448.1	IrmA family protein	-
KGP17_RS23220 (KGP17_23135)	4996432..4996866	+	435	WP_223498449.1	antirestriction protein	-
KGP17_RS23225 (KGP17_23140)	4996884..4997372	+	489	WP_223498450.1	DNA repair protein RadC	-
KGP17_RS23230 (KGP17_23145)	4997366..4997686	+	321	WP_223498451.1	DUF5983 family protein	-
KGP17_RS23235 (KGP17_23150)	4997750..4998232	+	483	WP_223498452.1	hypothetical protein	-
KGP17_RS23240 (KGP17_23155)	4998245..4998580	+	336	WP_223498453.1	TA system toxin CbtA family protein	-
KGP17_RS23245 (KGP17_23160)	4998658..4999035	+	378	WP_223498454.1	type IV toxin-antitoxin system YeeU family antitoxin	-
KGP17_RS23250 (KGP17_23165)	4999114..4999971	+	858	WP_223498455.1	DUF4942 domain-containing protein	-
KGP17_RS23255 (KGP17_23170)	5000088..5000369	+	282	WP_223498456.1	ribbon-helix-helix domain-containing protein	Antitoxin
KGP17_RS27900	5000509..5000643	+	135	WP_245398320.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KGP17_RS23265 (KGP17_23180)	5000934..5002046	-	1113	WP_223498457.1	M20 family metallopeptidase	-
KGP17_RS23270 (KGP17_23185)	5002143..5002604	-	462	WP_037434993.1	YjiG family protein	-
KGP17_RS23275 (KGP17_23190)	5002621..5003355	-	735	WP_223498458.1	nucleoside recognition domain-containing protein	-
KGP17_RS23280 (KGP17_23195)	5003915..5004685	-	771	WP_223498459.1	histidine phosphatase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	blaSFC-1	-	4966166..5007261	41095

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-43)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-46)

Sequences

Toxin

Protein

• Length: 45 a.a.
• Molecular weight: 5538.39 Da
• Isoelectric Point: 10.5247

>T201657 WP_245398320.1 NZ_CP074147:5000509-5000643 [Serratia sp. JSRIV001]
MRPALARYEPREVRRLNIGNYEIHYELRVNALYILRVWHTRENR

Nucleotide

• Length: 135 bp

>T201657 NZ_CP098707:12721-13044 [Yersinia ruckeri]
ATGGAGTATCTAGAATTCATTGAGACCCCCGTATTTAGCAGGCGAAGAGCTGAACTGCTGCCAGATGATGACTTCAGAGC
TTTACAGGAGCATCTTCTTAAAAACCATGATCTTGGCGACACAATCAGTAAAACAGGTGGATGTAAGAAAATCCGCTGGA
GTCGCGAAGGCATGGGGAAGCGGGGGGGAGTAAGAGTTATTTATTACGTCATAACCAAATCGGGACGCCTTTATCTGCTA
CTGGTCTATCCCAAAAACGAAAAAGACGATCTGACTGAAGCCGAAAAAGCTGTCCTGAAATCGATAAGTCAGCAAATCGA
ATAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10503.87 Da
• Isoelectric Point: 4.8000

>AT201657 WP_223498456.1 NZ_CP074147:5000088-5000369 [Serratia sp. JSRIV001]
MGQSPTRVITAHVPAEMVEKFDELAANYDRSRGWIVKQVLAANIEQEENHHQMILRGLADVDESRVVEQTDVLKWINSLN
IDTPLPVPQSGQK

Nucleotide

• Length: 282 bp

>AT201657 NZ_CP098707:13090-13386 [Yersinia ruckeri]
ATGAAAACTGAACTGTTTAATGATCTCGTTGAAAGTATGCAACAGATGGTTGCTATTGAGAAAGGTACGCTCTCTGTTCC
AGCGGAAAACATCCATCGTCATCGACTTCCAGATGTAAAATCAATGCGTGAAGCGAGCGGTCTTAAGCAAAATGAATTTG
CGGATGTAGTGGGGGTTTCTGCTTCTCTGCTCCAGAGCTGGGAACAGCATCGTCGTATTCCATCAGGTTCATCTCTAAAG
TTGTTGATGATGATAGAGCGTGACCCAGCTGTTATAGACGCTTTACGAACGCTTTAG