Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4998245..4999035 Replicon chromosome
Accession NZ_CP074147
Organism Serratia sp. JSRIV001

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag KGP17_RS23240 Protein ID WP_223498453.1
Coordinates 4998245..4998580 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag KGP17_RS23245 Protein ID WP_223498454.1
Coordinates 4998658..4999035 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP17_RS23200 (KGP17_23115) 4994073..4994777 + 705 WP_223498446.1 transcriptional regulator -
KGP17_RS23205 (KGP17_23120) 4994777..4995346 + 570 WP_223499718.1 hypothetical protein -
KGP17_RS23210 (KGP17_23125) 4995385..4995837 + 453 WP_223498447.1 hypothetical protein -
KGP17_RS23215 (KGP17_23130) 4995834..4996286 + 453 WP_223498448.1 IrmA family protein -
KGP17_RS23220 (KGP17_23135) 4996432..4996866 + 435 WP_223498449.1 antirestriction protein -
KGP17_RS23225 (KGP17_23140) 4996884..4997372 + 489 WP_223498450.1 DNA repair protein RadC -
KGP17_RS23230 (KGP17_23145) 4997366..4997686 + 321 WP_223498451.1 DUF5983 family protein -
KGP17_RS23235 (KGP17_23150) 4997750..4998232 + 483 WP_223498452.1 hypothetical protein -
KGP17_RS23240 (KGP17_23155) 4998245..4998580 + 336 WP_223498453.1 TA system toxin CbtA family protein Toxin
KGP17_RS23245 (KGP17_23160) 4998658..4999035 + 378 WP_223498454.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KGP17_RS23250 (KGP17_23165) 4999114..4999971 + 858 WP_223498455.1 DUF4942 domain-containing protein -
KGP17_RS23255 (KGP17_23170) 5000088..5000369 + 282 WP_223498456.1 ribbon-helix-helix domain-containing protein -
KGP17_RS27900 5000509..5000643 + 135 WP_245398320.1 type II toxin-antitoxin system RelE/ParE family toxin -
KGP17_RS23265 (KGP17_23180) 5000934..5002046 - 1113 WP_223498457.1 M20 family metallopeptidase -
KGP17_RS23270 (KGP17_23185) 5002143..5002604 - 462 WP_037434993.1 YjiG family protein -
KGP17_RS23275 (KGP17_23190) 5002621..5003355 - 735 WP_223498458.1 nucleoside recognition domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island blaSFC-1 - 4966166..5007261 41095


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(15-102)

Antitoxin

Antitoxin CbeA

(25-123)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12531.36 Da        Isoelectric Point: 6.2133

>T201656 WP_223498453.1 NZ_CP074147:4998245-4998580 [Serratia sp. JSRIV001]
MKTMNKLPHTPSNASPAFLEYQQLLAWLLAHCYGLELNDTPYHDDQAITQQIEYGVTVRETVNELVEKFDLVRIDRPGFS
LMAQDPTLSAGDMLCARSARGLRSPVIRRLA

Download         Length: 336 bp

>T201656 NZ_CP098706:c3006660-3006238 [Yersinia ruckeri]
GTGGCCCAGTGGCGATGTGATCTGCGGGTTTCATGGCGCACCCAACTTTTCTCACTATTGGTACACGGTGTTCTGGTATT
ACTGACACTGGTGGTACCTTGGCCTGACGGATTTACTCCGCTATGGCTTATATTGCTGACGCTGGTGGTGTTTGAATGCA
TTCGCAGCCAGAAGAACATTACCTCTCGACAGGGAGAGATCCGGCTTAAAGCGGGAAATCTGTTGATTTGGAAGTGGCAA
GAGTGGACGTTGGTGCGGCCGCCGTGGATTACCCGCTACGGCGTATTATTATCGTTACAAGGCGCTGGCAGCCGCCGCCG
AAAACGTATTTGGCTAGCCTCCGACAGCATGTCGGAAGAAAAATGGCGCGAGTTGTGTCTGATATTACGACATACTTTTG
ATTCTGCGGCAGGCCGTGAGTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13783.81 Da        Isoelectric Point: 6.9474

>AT201656 WP_223498454.1 NZ_CP074147:4998658-4999035 [Serratia sp. JSRIV001]
MKEPVLNTDNNAAPLTDEDNIPSPVWGLHCAITPRLGARLVQKGNRLHFLPDRAGFVGMFSPDALKTLDRAFPVLIKLLE
ACLRSGELDQRRQHCVTVQHAGFTCEADTLGSFGHVYLAVYQTPT

Download         Length: 378 bp

>AT201656 NZ_CP098706:c3006907-3006641 [Yersinia ruckeri]
ATGGAAATTGATAACAAAGCCCGAATCCATTGGGCATGCCGCCGGGGTATGCGTGAACTGGATATCTCCATAATGCCATT
TTTCGAACATGAATATGACACGCTAAACGATAATGATAAGCGCGTATTTATCCGCTTGCTGACGAGTGATGATCCTGATT
TATTCAATTGGTTGATGAACCACGGCGAGCCGCAGGATAGCGAACTGAAACGAATGGTTAAACTGATTCAGACACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References