Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 4932540..4933117 Replicon chromosome
Accession NZ_CP074147
Organism Serratia sp. JSRIV001

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KGP17_RS22870 Protein ID WP_223498409.1
Coordinates 4932785..4933117 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag KGP17_RS22865 Protein ID WP_223498408.1
Coordinates 4932540..4932785 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP17_RS22825 (KGP17_22745) 4928258..4928953 + 696 WP_223498400.1 IS6 family transposase -
KGP17_RS22830 (KGP17_22750) 4929019..4929387 + 369 Protein_4471 Tm-1-like ATP-binding domain-containing protein -
KGP17_RS22835 (KGP17_22755) 4929384..4930211 + 828 WP_223498402.1 phosphoenolpyruvate hydrolase family protein -
KGP17_RS22840 (KGP17_22760) 4930440..4930934 + 495 WP_223498403.1 hypothetical protein -
KGP17_RS22845 (KGP17_22765) 4931196..4931435 + 240 WP_223498404.1 helix-turn-helix domain-containing protein -
KGP17_RS22850 (KGP17_22770) 4931458..4931781 + 324 WP_223498405.1 hypothetical protein -
KGP17_RS22855 (KGP17_22775) 4931778..4932008 + 231 WP_223498406.1 hypothetical protein -
KGP17_RS22860 (KGP17_22780) 4932166..4932372 + 207 WP_223498407.1 hypothetical protein -
KGP17_RS22865 (KGP17_22785) 4932540..4932785 + 246 WP_223498408.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KGP17_RS22870 (KGP17_22790) 4932785..4933117 + 333 WP_223498409.1 endoribonuclease MazF Toxin
KGP17_RS22875 (KGP17_22795) 4933131..4933445 + 315 WP_223498410.1 hypothetical protein -
KGP17_RS22880 (KGP17_22800) 4933969..4934139 + 171 WP_223498411.1 hypothetical protein -
KGP17_RS22885 (KGP17_22805) 4935024..4935569 + 546 WP_245398329.1 plasmid pRiA4b ORF-3 family protein -
KGP17_RS22890 (KGP17_22810) 4935749..4936590 + 842 Protein_4483 ISKra4 family transposase -
KGP17_RS22895 (KGP17_22815) 4937121..4937516 + 396 WP_223498390.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fimC / fimD / fimC / fimD 4908273..4965724 57451
- flank IS/Tn - - 4928258..4928953 695
- flank IS/Tn - - 4935749..4936579 830


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-107)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11901.85 Da        Isoelectric Point: 8.4953

>T201655 WP_223498409.1 NZ_CP074147:4932785-4933117 [Serratia sp. JSRIV001]
MVKGYVPDAGDIVWLEFDPQAGHEQAGHRPALVLSPAVYNGRIGLMLCCPMTTKIKGYPFEVIVPGERESAVLADQVKSL
DWKERNATKKGQVPASVLSDVRAKAKALIG

Download         Length: 333 bp

>T201655 NZ_CP098706:2811926-2812255 [Yersinia ruckeri]
ATGCAAACCTTATCATCACACCCGACACGGGCGTCTCAGCCCTGCCTGTCACCCGTTGAAATCTGGCAGCTGCTGCTGAC
TCATTTGTTGTCGCAGCACTATGGCCTGACGCTGAATGACACACCGTTCATTAATGAAACCACCATCCGGGAACATATTG
ATGCTGGAGTATCGCTCAGCGATGCGGTGAACTTTCTGGTAGAAAAATATGGGCTTGTCCGTATCGACCGGAAGGGATTT
TCGTGGCAAGAACAGACCCCATATATTTCCGTAGTTGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACCAA
CGTGAAATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8600.94 Da        Isoelectric Point: 4.9861

>AT201655 WP_223498408.1 NZ_CP074147:4932540-4932785 [Serratia sp. JSRIV001]
MSQVVVKKWGNSPSVRLPVAVMKAASLNVDDTVEVSVEEGRIVIVPVRAKVYSLDGLLAGVTDENIHQAVSFGEPVGKEA
L

Download         Length: 246 bp

>AT201655 NZ_CP098706:2811522-2811887 [Yersinia ruckeri]
ATGAACAATCACTCAGAATCCGTTACCAAGCCGGAGAATCCCGCCTGCCAGCAGTGGGGACTAAAGAGTACGATCACACC
CTGTTTTGGAGCTCGTCTGGTGCTGGAAGGCAACCGCTTGCATTTTCTCGCTGACCGGGCCGGATTCAACGGTGCTTTCA
GCGACGATGACGCGCTGCACCTAGATCATGCCTTTCCGTTGATACTCAAGCAACTGGAGCTGATGCTCACCAGCGGAGAA
CTCTCTCCCCGGCATCAGCACTGCGTCACGCTATATCACAACGGACTCACTTGCGAAGCCGACACACTCGGCTCCTGTGG
CTATGTCTACATTGCTATTTATCCTGACCAGACTGAGCCGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References