Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4686395..4687064 Replicon chromosome
Accession NZ_CP074147
Organism Serratia sp. JSRIV001

Toxin (Protein)


Gene name cptA Uniprot ID U2LMQ5
Locus tag KGP17_RS21705 Protein ID WP_021179806.1
Coordinates 4686395..4686817 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID U2M6Q5
Locus tag KGP17_RS21710 Protein ID WP_021179805.1
Coordinates 4686798..4687064 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP17_RS21685 (KGP17_21605) 4682239..4682757 + 519 WP_021179810.1 flavodoxin FldB -
KGP17_RS21690 (KGP17_21610) 4682793..4684181 - 1389 WP_021806193.1 cell envelope integrity protein CreD -
KGP17_RS21695 (KGP17_21615) 4684285..4685703 - 1419 WP_179251827.1 two-component system sensor histidine kinase CreC -
KGP17_RS21700 (KGP17_21620) 4685700..4686395 - 696 WP_021806195.1 two-component system response regulator CreB -
KGP17_RS21705 (KGP17_21625) 4686395..4686817 - 423 WP_021179806.1 protein YgfX Toxin
KGP17_RS21710 (KGP17_21630) 4686798..4687064 - 267 WP_021179805.1 FAD assembly factor SdhE Antitoxin
KGP17_RS21715 (KGP17_21635) 4687365..4688357 + 993 WP_037375809.1 tRNA-modifying protein YgfZ -
KGP17_RS21720 (KGP17_21640) 4688397..4688894 - 498 WP_021806198.1 DUF2165 domain-containing protein -
KGP17_RS21725 (KGP17_21645) 4689126..4689800 - 675 WP_037375710.1 hemolysin III family protein -
KGP17_RS21730 (KGP17_21650) 4690037..4690645 + 609 WP_094981477.1 HD domain-containing protein -
KGP17_RS21735 (KGP17_21655) 4690679..4691425 - 747 WP_094981476.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-130)

Antitoxin

Flavinator of succinate dehydrogenase

(7-78)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16466.40 Da        Isoelectric Point: 10.6373

>T201654 WP_021179806.1 NZ_CP074147:c4686817-4686395 [Serratia sp. JSRIV001]
VALWRCDVRVSWRTQLVSLLTHGLLILLILIAPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLAERRIEWHGR
EWLMVNKPWMPGFGILLSLQQIDGKKRHRLWLASDSMSKADWRQLRQRLSFEPSATDEDV

Download         Length: 423 bp

>T201654 NZ_CP098706:c2078486-2078393 [Yersinia ruckeri]
TAAGCCTGCATGAAATGCCAACTTTTAGCGCACGGCTCTATCCCAAGAGCCATTTCCCTGGACCGAATATAGGATTCGTA
TTCGGTCTTTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10363.93 Da        Isoelectric Point: 5.5847

>AT201654 WP_021179805.1 NZ_CP074147:c4687064-4686798 [Serratia sp. JSRIV001]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDADKAVFIRLLECDDPDLFNWLMNHGAPQDQDLQRMVSLIQMRN
KARGPVAM

Download         Length: 267 bp

>AT201654 NZ_CP098706:2078389-2078535 [Yersinia ruckeri]
AGATAAAAAAAGACCGAATACGAATCCTATATTCGGTCCAGGGAAATGGCTCTTGGGATAGAGCCGTGCGCTAAAAGTTG
GCATTTCATGCAGGCTTATTAAGCCGTACCACTTAAGCGTAGTAGACGACCCACATTTTACCAATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2LMQ5

Antitoxin

Source ID Structure
AlphaFold DB U2M6Q5

References