Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4507208..4507851 Replicon chromosome
Accession NZ_CP074147
Organism Serratia sp. JSRIV001

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag KGP17_RS20930 Protein ID WP_223498271.1
Coordinates 4507208..4507624 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag KGP17_RS20935 Protein ID WP_223498272.1
Coordinates 4507621..4507851 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP17_RS20910 (KGP17_20830) 4502274..4503725 + 1452 WP_223498269.1 efflux transporter outer membrane subunit -
KGP17_RS20915 (KGP17_20835) 4503747..4504919 + 1173 WP_024484847.1 multidrug efflux MFS transporter periplasmic adaptor subunit EmrA -
KGP17_RS20920 (KGP17_20840) 4504976..4506472 + 1497 WP_235050830.1 multidrug efflux MFS transporter permease subunit EmrB -
KGP17_RS20925 (KGP17_20845) 4506752..4507039 - 288 WP_223498270.1 hypothetical protein -
KGP17_RS20930 (KGP17_20850) 4507208..4507624 - 417 WP_223498271.1 PIN domain-containing protein Toxin
KGP17_RS20935 (KGP17_20855) 4507621..4507851 - 231 WP_223498272.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KGP17_RS20940 (KGP17_20860) 4508100..4509191 - 1092 WP_021178989.1 tRNA/rRNA methyltransferase -
KGP17_RS20945 (KGP17_20865) 4509388..4509807 + 420 WP_094981235.1 thioredoxin TrxC -
KGP17_RS20950 (KGP17_20870) 4509924..4510628 + 705 WP_223498273.1 tRNA-uridine aminocarboxypropyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15130.47 Da        Isoelectric Point: 7.7809

>T201653 WP_223498271.1 NZ_CP074147:c4507624-4507208 [Serratia sp. JSRIV001]
MNKTYMLDTNICSFIMREQPEAVIRRLEQAVMRNHRIVVSAITYAEMCFGTIGKKASPRHARLVEAFCSRLDAVLAWDRA
AVDATTNIKATLAAAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVTDLILEDWAK

Download         Length: 417 bp

>T201653 NZ_CP098706:1877707-1878165 [Yersinia ruckeri]
GTGATGCTCTACCGGATAGTTCACAACCGTTACCTGGCAACGGCCTGGACCGGATATGGCGCAGAAACCTATGGTGGCCG
CTGGAATCATAAAGGCCATGCGGCGATTTATCTGGCCAGTAGCGTTTCTCTGGCGATGCTCGAAACACTGGTGCATGTAG
AAGATAGCGCGACGCTGAACGATTTTAATCTATTTCAGATAACCATTCCCGATAATGCAATTATGGTACTGCAACAGCAA
GATTGGCCACGTGGATGGCGAGATGACCCCACCCCCGTGGCCACCATGGACATCGGCACCGAATGGATTGGTTCAGTATC
ATCTGTCGGTCTGCTGGTACCATCCACGTTAGTCCCTTTGGAAAGAAATATGCTGGTGAATCCTAAACACCGCGATTTCG
CCTCGTGCCTGAAAAGCATCAATCCACTGACGTTCAGTTTTGATCCTCGTCTAAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8831.91 Da        Isoelectric Point: 4.3142

>AT201653 WP_223498272.1 NZ_CP074147:c4507851-4507621 [Serratia sp. JSRIV001]
MRIVSVFKNGNNRAIRLPRDMDFEGVSELEITREGDSIILRPVRPSWGSFLQEEKADADFMTEREEIVSDEGRFEL

Download         Length: 231 bp

>AT201653 NZ_CP098706:1877247-1877693 [Yersinia ruckeri]
ATGAGAACTTATCACCCAAGCCCGATGGCCAAAGTCAGCGCACTATGGCGTGAGATTGGTCTACCCGCCAGTCGTGGCAC
CGCTTTGGTGGACAGCATAAAACTGGGATTTACTGTGGATGTGATCGACACTATACATTTATGGGCTGATATGCCTAAAT
CTGAAATATTACGCGCTACGGGCATTCCGAGCCGCAGTCTGACGCGCCGTCGTACCCATGATGGGCGTTTTACCCCGGAA
GAAAGCGAACGTATTGCACGGTTTGTCCGGGTTATGGATGCGGCGGTAGATTTGTTCGGTGGTGACCGCACCAAAGCAAC
CGCATGGATGTCGATGCCGGTCAAAGGGCTGGGTAATCGAACGCCCGATTCACTGCTGGAAACCGAAACCGGTGCGTTGG
AAATCTGCGACCTGATTGGTCGTCTCGAACATGGGGTCTTTTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References