Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 4295675..4296265 Replicon chromosome
Accession NZ_CP074147
Organism Serratia sp. JSRIV001

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KGP17_RS19925 Protein ID WP_140920016.1
Coordinates 4295969..4296265 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KGP17_RS19920 Protein ID WP_223498199.1
Coordinates 4295675..4295965 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP17_RS19895 (KGP17_19825) 4291752..4292201 + 450 WP_094982783.1 helix-turn-helix domain-containing protein -
KGP17_RS19900 (KGP17_19830) 4292204..4292500 + 297 WP_021807174.1 putative quinol monooxygenase -
KGP17_RS19905 (KGP17_19835) 4292631..4294073 - 1443 WP_223498198.1 glucosyltransferase domain-containing protein -
KGP17_RS19910 (KGP17_19840) 4294087..4294998 - 912 WP_059201516.1 glycosyltransferase family 2 protein -
KGP17_RS19915 (KGP17_19845) 4294995..4295351 - 357 WP_037376409.1 GtrA family protein -
KGP17_RS19920 (KGP17_19850) 4295675..4295965 - 291 WP_223498199.1 putative addiction module antidote protein Antitoxin
KGP17_RS19925 (KGP17_19855) 4295969..4296265 - 297 WP_140920016.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KGP17_RS19930 (KGP17_19860) 4296361..4297224 - 864 WP_223498200.1 phage integrase N-terminal domain-containing protein -
KGP17_RS19935 (KGP17_19865) 4298249..4298533 + 285 WP_223498201.1 HigA family addiction module antitoxin -
KGP17_RS19940 (KGP17_19870) 4298539..4301106 + 2568 WP_223498202.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - gtrB 4292631..4303808 11177


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-90)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11053.81 Da        Isoelectric Point: 10.1006

>T201651 WP_140920016.1 NZ_CP074147:c4296265-4295969 [Serratia sp. JSRIV001]
MYTIKTTHKFTEWLSSIKDGMTKRRLARRIEKAQFGNLGDCKPVGEGVWEMREHFGAGWRMYYIQRGTVLIVMLGGGDKS
SQSKDIAEAIALAATLKD

Download         Length: 297 bp

>T201651 NZ_CP098706:457637-458293 [Yersinia ruckeri]
GTGGCCTATGACTACAGCACTAGCCTCAACCCGGAAAAAGCCTTGATCTGGCGCATTGTCCATCGGGACAATATTCCGTG
GATACTGGACAACGGTCTGCACTGTGGCAACAGTCCGGTGCAGGCGGAAGACTGGATTAATATCGGTAACCCGGAGCTTA
TCGACAAACGTGCCGGACATCTGGTGCCAACCGGAATGCGGGGGACGCTGCATGACTATGTGCCGTTTTACTTTACTCCT
TTCTCGCCGATGCTGATGAATATCCGCAGCGGACGTGGCGGCATTAAGCAACGCCCCAATGAGGAGATCGTTATTCTGGT
CAGTAGCCTGCGAAACATGGTGGCGCAAAATGTCTCCTTCGTGTTTACCGATAGCCACGCATATTATAACCTGGCTAATT
ACTTTACCGAGCTGGACAGTCTGAACCAGATCGATTGGCCCATTCTACAAGCGCGGGATTTCCGTCGCGATCAGGACGAT
TTGGCCAAGTTCGAACGCTATCAGGCAGAGGCGTTAATTTGGAAGCACTGCCCAATAGCGCTGCTTGGCGGGATGATTTG
TTACAACGATGGCGTCAGGTTACAATTAGAGCAGTGGTTGTCGCAACGCAATCTGTCAATGCCCGTTCACGCGCGGGCTG
GGTGGTACTTCTCATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10348.81 Da        Isoelectric Point: 4.7672

>AT201651 WP_223498199.1 NZ_CP074147:c4295965-4295675 [Serratia sp. JSRIV001]
MKISNLPEFDVTEYLDSPEALAEYLTVVMEENDPAALAQALGTIARARGMSDIASASGISREALYKALRPDAHPRFDTIN
RVCAALGVKLVAQATR

Download         Length: 291 bp

>AT201651 NZ_CP098706:458290-459357 [Yersinia ruckeri]
ATGATTACATTTACACAAGGCAATTTACTGGATGCGCCCGTAGAAGCACTAGTGAATACGGTTAATACCGTCGGTGTCAT
GGGTAAAGGCATCGCGCTGATGTTCAAAGAGCGCTTCCCCGTCAATATGAAAGCCTATGCTCTCGCCTGCAAACATAAGC
AGGTAATGACAGGTAAAATGTTTATTACCGAAACCGGCGAACTGATGGGGCCTCGCTGGATTGTCAACTTCCCAACTAAA
CAACACTGGCGCGCAGACTCCCGCATGGAGTGGGTTGAAGACGGCTTGCAGGATTTACGCCGCTTTTTGATCGAAGAGAA
AGTGCAATCTATCGCCATTCCCCCACTGGGGGCGGGTAACGGCGGCCTGAATTGGTCGGACGTTCGGATGCGGATTGAAT
CTGCGCTGGGCGACCTTCAGGACACGGAAATTCTGATTTATGAGCCTACCGAAAAATACCAGAACGTCGCCAAGAGCACC
GGCGTAAAAAAGCTCACTCCCGCCAGAGCGCTGATTGCTGAACTGGTGCGCCGCTACTGGGTGCTGGGCATGGAGTGCAG
CCTGCTGGAAATCCAGAAGCTGGCATGGCTGTTACAACGCGCCATTGAACAGCATCAGCAGGAAGATGTGCTGAAACTGC
GGTTTGAGGCGCACTATTACGGCCCCTACGCCCCCAACCTTAACCATCTGCTTAACGCGCTAGATGGCACGTATCTGAAA
GCAGAGAAACGCATCCCGGACACCCAGCCGCTGGATGTGATCTGGTTTAATGATCAGGAAAAAGAACACATCAACCTCTG
GCTGAACAACGAGGCCAAAGAGTGGCTACCGGCGCTTGAGCAGGTCAGTCAGTTGATTGACGGCTTTGAATCGCCGTTTG
GTCTGGAGCTGCTGGCAACCGTTGACTGGCTGCTGACCCGAGGAAAATGCCAGCCCACGCTGGATTCCGTGAAAGAGGGG
CTGCACCAGTGGCCTGCGGGTGAACGCTGGGCCAGCCGTAAGATGAAGCTCTTTGACGACAAGAATCTGCAATTTGCCAT
CAACCGCGTGATGGAGTTCCATTGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References