Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4260954..4261610 Replicon chromosome
Accession NZ_CP074147
Organism Serratia sp. JSRIV001

Toxin (Protein)


Gene name vapC Uniprot ID A0A0U4J950
Locus tag KGP17_RS19735 Protein ID WP_021807143.1
Coordinates 4260954..4261343 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U2NVJ4
Locus tag KGP17_RS19740 Protein ID WP_021178792.1
Coordinates 4261347..4261610 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP17_RS19720 (KGP17_19650) 4257409..4258854 + 1446 WP_223498189.1 MFS transporter -
KGP17_RS19725 (KGP17_19655) 4258851..4260221 + 1371 WP_179247664.1 two-component system sensor histidine kinase BaeS -
KGP17_RS19730 (KGP17_19660) 4260234..4260950 + 717 WP_021807142.1 two-component system response regulator BaeR -
KGP17_RS19735 (KGP17_19665) 4260954..4261343 - 390 WP_021807143.1 type II toxin-antitoxin system VapC family toxin Toxin
KGP17_RS19740 (KGP17_19670) 4261347..4261610 - 264 WP_021178792.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KGP17_RS19745 (KGP17_19675) 4261957..4262295 + 339 WP_021178793.1 YegP family protein -
KGP17_RS19750 (KGP17_19680) 4262476..4263828 + 1353 WP_021178794.1 tRNA 5-hydroxyuridine modification protein YegQ -
KGP17_RS19755 (KGP17_19685) 4264365..4265264 + 900 WP_059201495.1 lipid kinase YegS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14260.54 Da        Isoelectric Point: 7.8799

>T201650 WP_021807143.1 NZ_CP074147:c4261343-4260954 [Serratia sp. JSRIV001]
MYMFDTNTVSQLFRQHPRLLAAMGRVPPSSVCISSITQAELLYGVAKRQNKALKQTVMMFLDAVTVYSWDSAAAHCYGVM
RASMEKQGRPMGALDQLIAAHAVSRGATIVTSDRAFTMVAELEVEDWTL

Download         Length: 390 bp

>T201650 NZ_CP098706:455992-456282 [Yersinia ruckeri]
ATGACCTTTAATATCGACTTTGACGAACGGGCATTAAAAGAATGGCACAAACTAGATAAAACTATCCGAGAGCAATTTAA
AAAGAAACTAAGAAAATTACAGGAAAATCCCTATATTGAGTCAGCACGTTTGCACGGTGATCTGGCTGGTTGTTTCAAAA
TAAAATTACGCGCATCTGGCTTTCGGTTGATTTACCAAGTTATCGATGAGGAGATTGTGATTTTGATCGTTGCTGTTGGT
AAACGGGAAGATGAAAAAGCTTATGATCTTGCCAAGAAGCGAATCCAATAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10157.53 Da        Isoelectric Point: 4.8232

>AT201650 WP_021178792.1 NZ_CP074147:c4261610-4261347 [Serratia sp. JSRIV001]
MERVAKLFKNGRNQAVRLPVEFEFDVDQVYIRRDEQGNVILSKHPMKLDSWQPLLTMLQNVAVPADFLTADDRQQGVAER
DPFKEEQ

Download         Length: 264 bp

>AT201650 NZ_CP098706:455748-456002 [Yersinia ruckeri]
ATGAGTACTATCCAAATTCGTGTGGATGATGAACTGAAGAAAAGTGCATATCAGGCGTTTGAAAAACTGAATCTTTCGCC
TTCTGATGCACTACGCCTGTTCCTACGTTATGTTGCAGAGAACGAAAAGCTGCCTTTTTCAGAAGTATCCGTCATGGTCA
GTAATCAAGATGAGGATGCTGATATTTTGGCTGTTGTCCGTGAACGTTTGAAAAATCCTGCAAAGCGTATCAGAGTAAAT
ATTGATGACCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U4J950

Antitoxin

Source ID Structure
AlphaFold DB U2NVJ4

References