Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3459245..3460027 Replicon chromosome
Accession NZ_CP074147
Organism Serratia sp. JSRIV001

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag KGP17_RS16055 Protein ID WP_223497969.1
Coordinates 3459245..3459580 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag KGP17_RS16060 Protein ID WP_223497970.1
Coordinates 3459659..3460027 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP17_RS16005 (KGP17_15940) 3454410..3455114 + 705 WP_223497960.1 WYL domain-containing protein -
KGP17_RS16010 (KGP17_15945) 3455177..3455395 + 219 WP_223497961.1 hypothetical protein -
KGP17_RS16015 (KGP17_15950) 3455398..3455637 + 240 WP_223497962.1 hypothetical protein -
KGP17_RS16020 (KGP17_15955) 3455809..3456633 + 825 WP_223497963.1 DUF932 domain-containing protein -
KGP17_RS16025 (KGP17_15960) 3456633..3456881 + 249 WP_223497964.1 hypothetical protein -
KGP17_RS16030 (KGP17_15965) 3457000..3457452 + 453 Protein_3140 antirestriction protein -
KGP17_RS16035 (KGP17_15970) 3457467..3457955 + 489 WP_223497965.1 DNA repair protein RadC -
KGP17_RS16040 (KGP17_15975) 3457994..3458371 + 378 WP_223497966.1 hypothetical protein -
KGP17_RS16045 (KGP17_15980) 3458368..3458688 + 321 WP_223497967.1 DUF5983 family protein -
KGP17_RS16050 (KGP17_15985) 3458750..3459232 + 483 WP_223497968.1 hypothetical protein -
KGP17_RS16055 (KGP17_15990) 3459245..3459580 + 336 WP_223497969.1 TA system toxin CbtA family protein Toxin
KGP17_RS16060 (KGP17_15995) 3459659..3460027 + 369 WP_223497970.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KGP17_RS16065 (KGP17_16000) 3460103..3460960 + 858 WP_223497971.1 DUF4942 domain-containing protein -
KGP17_RS16070 (KGP17_16005) 3461081..3461362 + 282 WP_223497972.1 type II toxin-antitoxin system RelE/ParE family toxin -
KGP17_RS16075 (KGP17_16010) 3461403..3461714 + 312 WP_223497973.1 putative addiction module antidote protein -
KGP17_RS16080 (KGP17_16015) 3462106..3462408 - 303 WP_021181020.1 chaperone modulator CbpM -
KGP17_RS16085 (KGP17_16020) 3462408..3463328 - 921 WP_059201073.1 curved DNA-binding protein -
KGP17_RS16090 (KGP17_16025) 3463937..3464743 - 807 WP_223497974.1 dimethyl sulfoxide reductase anchor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(20-103)

Antitoxin

Antitoxin CbeA

(17-115)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12501.29 Da        Isoelectric Point: 6.6384

>T201648 WP_223497969.1 NZ_CP074147:3459245-3459580 [Serratia sp. JSRIV001]
MKTINKLPHTPTHANPTFIEYQQLLAWLLGHCYGLELNDTPYHDDQAIAQQIEHGITVRETVNELVEKFDLVRIDRPGFS
LMAQDPTLSGGDLLRARSALGLRSPAIRRLA

Download         Length: 336 bp

>T201648 NZ_CP098703:c3127437-3126781 [Yersinia ruckeri]
GTGGCCTATGACTACAGCACTAGCCTCAACCCGGAAAAAGCCTTGATCTGGCGCATTGTCCATCGGGACAATATTCCGTG
GATACTGGACAACGGTCTGCACTGTGGCAACAGTCCGGTGCAGGCGGAAGACTGGATTAATATCGGTAACCCGGAGCTTA
TCGACAAACGTGCCGGACATCTGGTGCCAACCGGAATGCGGGGGACGCTGCATGACTATGTGCCGTTTTACTTTACTCCT
TTCTCGCCGATGCTGATGAATATCCGCAGCGGACGTGGCGGCATTAAGCAACGCCCCAATGAGGAGATCGTTATTCTGGT
CAGTAGCCTGCGAAACATGGTGGCGCAAAATGTCTCCTTCGTGTTTACCGATAGCCACGCATATTATAACCTGGCTAATT
ACTTTACCGAGCTGGACAGTCTGAACCAGATCGATTGGCCCATTCTACAAGCGCGGGATTTCCGTCGCGATCAGGACGAT
TTGGCCAAGTTCGAACGCTATCAGGCAGAGGCGTTAATTTGGAAGCACTGCCCAATAGCGCTGCTTGGCGGGATGATTTG
TTACAACGATGGCGTCAGGTTACAATTAGAGCAGTGGTTGTCGCAACGCAATCTGTCAATGCCCGTTCACGCGCGGGCTG
GGTGGTACTTCTCATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13401.97 Da        Isoelectric Point: 6.3645

>AT201648 WP_223497970.1 NZ_CP074147:3459659-3460027 [Serratia sp. JSRIV001]
MKDSDTDNHEDSTPSPIWGLHCAITPRLGARLVQQGNRLHFLVDRAGLVGTFSPNDLKGLNSAFPVLIEQLETCLRSGEL
DQRRQHCVTVQHAGFTCQADTLGSFGHVYIAVYQTAQHTSGE

Download         Length: 369 bp

>AT201648 NZ_CP098703:c3126784-3125717 [Yersinia ruckeri]
ATGATTACATTTACACAAGGCAATTTACTGGATGCGCCCGTAGAAGCACTAGTGAATACGGTTAATACCGTCGGTGTCAT
GGGTAAAGGCATCGCGCTGATGTTCAAAGAGCGCTTCCCCGTCAATATGAAAGCCTATGCTCTCGCCTGCAAACATAAGC
AGGTAATGACAGGTAAAATGTTTATTACCGAAACCGGCGAACTGATGGGGCCTCGCTGGATTGTCAACTTCCCAACTAAA
CAACACTGGCGCGCAGACTCCCGCATGGAGTGGGTTGAAGACGGCTTGCAGGATTTACGCCGCTTTTTGATCGAAGAGAA
AGTGCAATCTATCGCCATTCCCCCACTGGGGGCGGGTAACGGCGGCCTGAATTGGTCGGACGTTCGGATGCGGATTGAAT
CTGCGCTGGGCGACCTTCAGGACACGGAAATTCTGATTTATGAGCCTACCGAAAAATACCAGAACGTCGCCAAGAGCACC
GGCGTAAAAAAGCTCACTCCCGCCAGAGCGCTGATTGCTGAACTGGTGCGCCGCTACTGGGTGCTGGGCATGGAGTGCAG
CCTGCTGGAAATCCAGAAGCTGGCATGGCTGTTACAACGCGCCATTGAACAGCATCAGCAGGAAGATGTGCTGAAACTGC
GGTTTGAGGCGCACTATTACGGCCCCTACGCCCCCAACCTTAACCATCTGCTTAACGCGCTAGATGGCACGTATCTGAAA
GCAGAGAAACGCATCCCGGACACCCAGCCGCTGGATGTGATCTGGTTTAATGATCAGGAAAAAGAACACATCAACCTCTG
GCTGAACAACGAGGCCAAAGAGTGGCTACCGGCGCTTGAGCAGGTCAGTCAGTTGATTGACGGCTTTGAATCGCCGTTTG
GTCTGGAGCTGCTGGCAACCGTTGACTGGCTGCTGACCCGAGGAAAATGCCAGCCCACGCTGGATTCCGTGAAAGAGGGG
CTGCACCAGTGGCCTGCGGGTGAACGCTGGGCCAGCCGTAAGATGAAGCTCTTTGACGACAAGAATCTGCAATTTGCCAT
CAACCGCGTGATGGAGTTCCATTGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References