Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1499983..1500663 Replicon chromosome
Accession NZ_CP074147
Organism Serratia sp. JSRIV001

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag KGP17_RS06740 Protein ID WP_223499608.1
Coordinates 1500349..1500663 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag KGP17_RS06735 Protein ID WP_223499071.1
Coordinates 1499983..1500306 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP17_RS06725 (KGP17_06705) 1498516..1499663 + 1148 WP_223499070.1 IS3 family transposase -
KGP17_RS06730 (KGP17_06710) 1499683..1499970 + 288 Protein_1302 hypothetical protein -
KGP17_RS06735 (KGP17_06715) 1499983..1500306 + 324 WP_223499071.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KGP17_RS06740 (KGP17_06720) 1500349..1500663 + 315 WP_223499608.1 TA system toxin CbtA family protein Toxin
KGP17_RS06745 (KGP17_06725) 1500778..1501611 + 834 WP_223499072.1 DUF4942 domain-containing protein -
KGP17_RS06750 (KGP17_06730) 1502060..1503001 + 942 WP_021805406.1 6-phosphofructokinase II -
KGP17_RS06755 (KGP17_06735) 1503267..1503617 + 351 WP_094981158.1 transcriptional regulator -
KGP17_RS06760 (KGP17_06740) 1503666..1504028 + 363 WP_021805404.1 arsenite efflux transporter metallochaperone ArsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1476827..1519068 42241


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(10-103)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11749.24 Da        Isoelectric Point: 6.0591

>T201639 WP_223499608.1 NZ_CP074147:1500349-1500663 [Serratia sp. JSRIV001]
ISSVPASVPVSSRPSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDTAIQEHIEAGITLADAVNFLVNRYELVRTDRKGFSW
QEQTPFLTATDILRARRATGLMNT

Download         Length: 315 bp

>T201639 NZ_CP098701:c3190361-3189411 [Yersinia ruckeri]
ATGGATGATTTAACAAAGCTATTCCCAGATGTTGCTGATGCTCTGGGCATTGAATCTGTTTCAATTGTAGAAAAAGATTA
TTACATCGTTGAGTTATTACGATTGCTCCAGCCTATGGACTTTGACACGCATCAGCTGGTTTTTGCCGGTGGAACAGCAT
TGTCAAAAGCGGGTATATCTTTGAACAGGATGTCGGAAGACGTGGACATTAAGCTTGTCCCCGTCGCTGGTTTTACCCAG
CAATATTCCAGAGGCCAGCGTAAAGACATTCGTAAGGGTATTATTCGGACCGTTATCGAAACGATTACAGCTTCAGGTAC
GTTTCGCATGGATGAAGGGTATCCAAAGGTTACTCGTGATGAATATCGCTATAATGAAATTCCGGTGCGTTACCCGCAGG
AATATGTACAAGTTCCCTGCTTAAGGCCATTTATCAAACTGGAACTGATGGAAACGGATTTGCTTGAGGCTGCGGAAAAT
CGTGCTATTAGCTCCTTGGTAATGGATCTAACAAAGAAGGGCGAAGTAGTGAGGGCTTTCCCTTGCGCAACCATCGGTAG
CACGCAGGCTGAAAAACTGATCTCGATGATGCGCAGAACGGCTGCAAGTATGCGTGATGTGGAACGTGCAGTGGATGAAT
CACTGGTACGTCATATCTACGATAATTTTTGTATTGTTAGAGAAAAAGGTGCTGACGTTCCTGTTTTGAAGCAATTCGTG
CAGGAATGCATTGAACAGGATATTGAACGTTACGGTGCTCAGTACCCTGAATTCTGCGAGTCGCCTGTCGAAGAACTAAA
AATGGGGCTGGAAGAACTCGTGAGCAATCCTGTTTATAAGGAACGCTATCTGCAATTCGTCACACCAATGGTCTTCGGTG
AAAGCCACGTTTCATGGGAAGAGGCCTATGCCTGTTTTCGCAAAACGGTATTGGATGTGGTTGATGCATAG

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12055.63 Da        Isoelectric Point: 5.5412

>AT201639 WP_223499071.1 NZ_CP074147:1499983-1500306 [Serratia sp. JSRIV001]
MPLTPPHEWGLQSDITPQFGARLVQEGNRLHYLTDRAGLTGSFSPEQLQKLDQAFPLFIEQLENLLRSGELNPRQQHQVT
IQLASLTCIADTRGSCGYVYISIYPTQ

Download         Length: 324 bp

>AT201639 NZ_CP098701:c3190749-3190354 [Yersinia ruckeri]
ATGACTACAAAAGCTCGTATTCAGTTACGACTGAAACGCTCAAAGCGTTATGTTTTCACTCGTGACGATTTCAAAGATCT
TGCTGGCTACGACCAAATTGGTAGAGCACTGCGTGAACTGGTGAAGGAAGGGCAGCTGCTGAAAGTAGGCTATGGCGTCT
ACACCAAAGCGCGGCAAAATGTGATTACCGGTAAGTTGATGCCTGCGGCTCCCGGAGGTTCGGCTGCGGTAGTGATTGAG
GCGTTGGAACGTCTGAAAGTGGATTACCGCTTGGTTGGAGCAACAAGCGCCTATAATAGCGGTAAATCCACTCAGATCCC
CGCTTCACTGGAAATCAAAACCTCACCACGTTTTAAGAGGACATTGTCAGTAGGGAGCAGCAAACTAAATGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References