Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1402209..1402831 Replicon chromosome
Accession NZ_CP074147
Organism Serratia sp. JSRIV001

Toxin (Protein)


Gene name Hha Uniprot ID U2M374
Locus tag KGP17_RS06310 Protein ID WP_021180142.1
Coordinates 1402209..1402412 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID U2NAN4
Locus tag KGP17_RS06315 Protein ID WP_021180141.1
Coordinates 1402463..1402831 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP17_RS06285 (KGP17_06270) 1398039..1398527 + 489 WP_021180151.1 YbaY family lipoprotein -
KGP17_RS06290 (KGP17_06275) 1398581..1398895 - 315 WP_021180150.1 MGMT family protein -
KGP17_RS06300 (KGP17_06285) 1399276..1401063 - 1788 WP_223499045.1 adenine deaminase C-terminal domain-containing protein -
KGP17_RS06305 (KGP17_06290) 1401201..1402127 + 927 WP_059200026.1 LysR family transcriptional regulator -
KGP17_RS06310 (KGP17_06295) 1402209..1402412 - 204 WP_021180142.1 HHA domain-containing protein Toxin
KGP17_RS06315 (KGP17_06300) 1402463..1402831 - 369 WP_021180141.1 Hha toxicity modulator TomB Antitoxin
KGP17_RS06320 (KGP17_06305) 1402988..1403341 - 354 WP_094981218.1 hypothetical protein -
KGP17_RS06325 (KGP17_06310) 1403721..1404413 + 693 WP_223499046.1 ABC transporter ATP-binding protein -
KGP17_RS06330 (KGP17_06315) 1404413..1405270 + 858 WP_094981189.1 metal ABC transporter permease -
KGP17_RS06335 (KGP17_06320) 1405296..1406174 + 879 WP_059200029.1 zinc ABC transporter substrate-binding protein -
KGP17_RS06340 (KGP17_06325) 1406281..1406421 - 141 WP_021805462.1 type B 50S ribosomal protein L36 -
KGP17_RS06345 (KGP17_06330) 1406434..1406691 - 258 WP_021180135.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8099.48 Da        Isoelectric Point: 6.9770

>T201638 WP_021180142.1 NZ_CP074147:c1402412-1402209 [Serratia sp. JSRIV001]
MTKIDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVAVWKFVR

Download         Length: 204 bp

>T201638 NZ_CP098701:c2040877-2040784 [Yersinia ruckeri]
TAAGCCTGCATGAAATGCCAACTTTTAGCGCACGGCTCTATCCCAAGAGCCATTTCCCTGGACCGAATATAGGATTCGTA
TTCGGTCTTTTTTT

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14097.78 Da        Isoelectric Point: 4.5140

>AT201638 WP_021180141.1 NZ_CP074147:c1402831-1402463 [Serratia sp. JSRIV001]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNELIEHIASFVMSFKIKYMDEGDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARTFRLFSGEGVCTTMKT

Download         Length: 369 bp

>AT201638 NZ_CP098701:2040780-2040926 [Yersinia ruckeri]
AGTTAAAAAAAGACCGAATACGAATCCTATATTCGGTCCAGGGAAATGGCTCTTGGGATAGAGCCGTGCGCTAAAAGTTG
GCATTTCATGCAGGCTTATTAAGCCGTACCACTTAAGCGTAGTAGACGACCCACATTTTACCAATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2M374

Antitoxin

Source ID Structure
AlphaFold DB U2NAN4

References