Detailed information of TA system TA201636

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeV-yfjZ/CbtA-CbeA
• Location: 672787..673576
• Replicon: chromosome
• Accession: NZ_CP074147
• Organism: Serratia sp. JSRIV001

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: KGP17_RS02975
• Protein ID: WP_223498842.1
• Coordinates: 672787..673122 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: KGP17_RS02980
• Protein ID: WP_223498843.1
• Coordinates: 673208..673576 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP17_RS02930 (KGP17_02920)	668036..668245	+	210	WP_223498834.1	hypothetical protein	-
KGP17_RS02935 (KGP17_02925)	668321..668782	+	462	WP_223498835.1	hypothetical protein	-
KGP17_RS02940 (KGP17_02930)	669113..669934	+	822	WP_223498836.1	DUF932 domain-containing protein	-
KGP17_RS02945 (KGP17_02935)	669934..670191	+	258	WP_223498837.1	hypothetical protein	-
KGP17_RS02950 (KGP17_02940)	670543..670995	+	453	WP_223498838.1	antirestriction protein	-
KGP17_RS02955 (KGP17_02945)	671006..671491	+	486	WP_223498839.1	DNA repair protein RadC	-
KGP17_RS02960 (KGP17_02950)	671540..671920	+	381	Protein_564	hypothetical protein	-
KGP17_RS02965 (KGP17_02955)	671917..672237	+	321	WP_223498840.1	DUF5983 family protein	-
KGP17_RS02970 (KGP17_02960)	672292..672774	+	483	WP_223498841.1	hypothetical protein	-
KGP17_RS02975 (KGP17_02965)	672787..673122	+	336	WP_223498842.1	TA system toxin CbtA family protein	Toxin
KGP17_RS02980 (KGP17_02970)	673208..673576	+	369	WP_223498843.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
KGP17_RS02985 (KGP17_02975)	673655..674509	+	855	Protein_569	DUF4942 domain-containing protein	-
KGP17_RS02990 (KGP17_02980)	674917..676188	-	1272	WP_059199595.1	HipA domain-containing protein	-
KGP17_RS02995 (KGP17_02985)	676191..676703	-	513	WP_021807854.1	helix-turn-helix transcriptional regulator	-
KGP17_RS03000 (KGP17_02990)	677077..677712	+	636	WP_021179138.1	carbonic anhydrase	-
KGP17_RS03005 (KGP17_02995)	677834..678550	+	717	WP_021179139.1	LuxR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	664477..685066	20589

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (16-102)

Antitoxin

• Antitoxin CbeA (18-116)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12444.27 Da
• Isoelectric Point: 5.5873

>T201636 WP_223498842.1 NZ_CP074147:672787-673122 [Serratia sp. JSRIV001]
MMIINTATPITANARQALAEYQQLLAWLLAHCYGLELNDTPYHDDQAIAQQIEHGVTVRETVNELVEKFDLVRIDRPGFS
LMAQDPTLNGGDMLRARSALGLRSPVIRRLT

Nucleotide

• Length: 336 bp

>T201636 NZ_CP098701:c937982-937779 [Yersinia ruckeri]
ATGACCAAAACTGACTACCTAATGCGTTTAAGAAAATGCACAACAATTGACACACTAGAGCGTGTTATTGAAAAAAATAA
GTATGAGCTATCTGATGATGAACTAGAATTATTCTATTCTGCTGCGGATCATCGTCTAGCTGAACTTACCATGAATAAGT
TATACGATAAAATCCCTGCAACTGTCTGGCAACATGTGAAGTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13229.85 Da
• Isoelectric Point: 5.4992

>AT201636 WP_223498843.1 NZ_CP074147:673208-673576 [Serratia sp. JSRIV001]
MKETQSNITSNDSTPSPVWGLQSAITPRLGARLVQQGNHLHFLADRAGFVGTFDPDALKTLDAAFPALIEQLEACLRSGE
LDPRRQHCVTVQHAGFSCEADSLGSFGYVYIAVYQTTPPNPV

Nucleotide

• Length: 369 bp

>AT201636 NZ_CP098701:c938402-938034 [Yersinia ruckeri]
ATGGATGAGTACTCACCTAAGCGACATGATATTGCTCAGTTGAAATTCTTATGTGAGAATTTGTATGATGAAGGTATCGC
CACATTGGGCGATAGCCACCACGGCTGGGTTAATGATCCAACCTCCGCGGTAAATCTCCAACTGAATGATTTAATCGAAC
ACATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACGCAGACGAAATCGATCTCTGCGAGTTGGTGGAGGAATATCTA
GACGATACATATACCTTGTTCAGCAGTTACGGAATCAATGATCCTGATTTACGCCGCTGGCAGAAAACAAAAGACCGATT
ATTCAGACTATTTTCAGGGGAATACCTATGTGCCCTGATGAAAAATTAA