Detailed information of TA system TA201635

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 566091..566662
• Replicon: chromosome
• Accession: NZ_CP074147
• Organism: Serratia sp. JSRIV001

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KGP17_RS02535
• Protein ID: WP_059199563.1
• Coordinates: 566387..566662 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U2NJB3
• Locus tag: KGP17_RS02530
• Protein ID: WP_021179086.1
• Coordinates: 566091..566378 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP17_RS02500 (KGP17_02490)	561319..562107	-	789	WP_024483394.1	phosphonate C-P lyase system protein PhnK	-
KGP17_RS02505 (KGP17_02495)	562107..562958	-	852	WP_021807491.1	alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase PhnJ	-
KGP17_RS02510 (KGP17_02500)	562951..564036	-	1086	WP_021179082.1	carbon-phosphorus lyase complex subunit PhnI	-
KGP17_RS02515 (KGP17_02505)	564021..564617	-	597	WP_223498789.1	phosphonate C-P lyase system protein PhnH	-
KGP17_RS02520 (KGP17_02510)	564621..565064	-	444	WP_179248704.1	phosphonate C-P lyase system protein PhnG	-
KGP17_RS02525 (KGP17_02515)	565065..565793	-	729	WP_223498790.1	phosphonate metabolism transcriptional regulator PhnF	-
KGP17_RS02530 (KGP17_02520)	566091..566378	+	288	WP_021179086.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KGP17_RS02535 (KGP17_02525)	566387..566662	+	276	WP_059199563.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KGP17_RS02540 (KGP17_02530)	566659..567123	-	465	WP_021807485.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
KGP17_RS02545 (KGP17_02535)	567402..569540	-	2139	WP_166733970.1	anaerobic ribonucleoside-triphosphate reductase	-
KGP17_RS02550 (KGP17_02540)	569852..570739	-	888	WP_218519932.1	LysR family transcriptional regulator	-
KGP17_RS02555 (KGP17_02545)	570844..571368	+	525	WP_179252830.1	NAD(P)H-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-44)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10613.23 Da
• Isoelectric Point: 4.2503

>T201635 WP_059199563.1 NZ_CP074147:566387-566662 [Serratia sp. JSRIV001]
MRIEWDDVALQDRERIFEFLYPLNSLAAEQVDDEIELAVESLLENPEMGRPWYGEARKLVISKASLLLIYVILDEVIKVL
AVAHQREKFPN

Nucleotide

• Length: 276 bp

>T201635 NZ_CP098701:698565-698987 [Yersinia ruckeri]
GTGGCCCAGTGGCGATGTGATCTGCGGGTTTCATGGCGCACCCAACTTTTCTCACTATTGGTACACGGTGTTCTGGTATT
ACTGACACTGGTGGTACCTTGGCCTGACGGATTTACTCCGCTATGGCTTATATTGCTGACGCTGGTGGTGTTTGAATGCA
TTCGCAGCCAGAAGAACATTACCTCTCGACAGGGAGAGATCCGGCTTAAAGCGGGAAATCTGTTGATTTGGAAGTGGCAA
GAGTGGACGTTGGTGCGGCCGCCGTGGATTACCCGCTACGGCGTATTATTATCGTTACAAGGCGCTGGCAGCCGCCGCCG
AAAACGTATTTGGCTAGCCTCCGACAGCATGTCGGAAGAAAAATGGCGCGAGTTGTGTCTGATATTACGACATACTTTTG
ATTCTGCGGCAGGCCGTGAGTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10957.35 Da
• Isoelectric Point: 8.0314

>AT201635 WP_021179086.1 NZ_CP074147:566091-566378 [Serratia sp. JSRIV001]
MESRIQFRIENETKLLAQKAAEAKGTTLSEACRRLAQQMADDQRAAEEHENWLKDKVDAAFARLHEGEAVYLTQRQAEER
MSDFKAKVRAKYATK

Nucleotide

• Length: 288 bp

>AT201635 NZ_CP098701:698318-698584 [Yersinia ruckeri]
ATGGAAATTGATAACAAAGCCCGAATCCATTGGGCATGCCGCCGGGGTATGCGTGAACTGGATATCTCCATAATGCCATT
TTTCGAACATGAATATGACACGCTAAACGATAATGATAAGCGCGTATTTATCCGCTTGCTGACGAGTGATGATCCTGATT
TATTCAATTGGTTGATGAACCACGGCGAGCCGCAGGATAGCGAACTGAAACGAATGGTTAAACTGATTCAGACACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: U2NJB3