Detailed information of TA system TA201633

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 65039..65574
• Replicon: plasmid pJSRIV002_2
• Accession: NZ_CP074145
• Organism: Serratia sp. JSRIV002

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KGP26_RS29530
• Protein ID: WP_223665711.1
• Coordinates: 65039..65326 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1Q5UY56
• Locus tag: KGP26_RS29535
• Protein ID: WP_074032216.1
• Coordinates: 65323..65574 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP26_RS29515 (KGP26_29410)	61926..62990	-	1065	WP_223665708.1	thioredoxin fold domain-containing protein	-
KGP26_RS29520 (KGP26_29415)	62995..64254	-	1260	WP_223665709.1	conjugal transfer protein TrbA	-
KGP26_RS29525 (KGP26_29420)	64346..65020	-	675	WP_223665710.1	plasmid IncI1-type surface exclusion protein ExcA	-
KGP26_RS29530 (KGP26_29425)	65039..65326	-	288	WP_223665711.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KGP26_RS29535 (KGP26_29430)	65323..65574	-	252	WP_074032216.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KGP26_RS29540 (KGP26_29435)	65681..67828	-	2148	WP_223665712.1	DotA/TraY family protein	-
KGP26_RS29545 (KGP26_29440)	67896..68405	-	510	WP_202811395.1	conjugal transfer protein TraX	-
KGP26_RS29550 (KGP26_29445)	68405..69598	-	1194	WP_223665713.1	conjugal transfer protein TraW	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..113805	113805

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11095.01 Da
• Isoelectric Point: 10.5846

>T201633 WP_223665711.1 NZ_CP074145:c65326-65039 [Serratia sp. JSRIV002]
MTYKVKFRTDALKEWNSLDRSIQQQFAKKLKKCTENPHIPSAKLRGMPDCYKIKLRASGFRLVYQVINDELIIAVVAVGK
REHSEVYNQANKRLK

Nucleotide

• Length: 288 bp

>T201633 NZ_CP098699:c52050-51727 [Yersinia ruckeri]
ATGGAGTATCTAGAATTCATTGAGACCCCCGTATTTAGCAGGCGAAGAGCTGAACTGCTGCCAGATGATGACTTCAGAGC
TTTACAGGAGCATCTTCTTAAAAACCATGATCTTGGCGACACAATCAGTAAAACAGGTGGATGTAAGAAAATCCGCTGGA
GTCGCGAAGGCATGGGGAAGCGGGGGGGAGTAAGAGTTATTTATTACGTCATAACCAAATCGGGACGCCTTTATCTGCTA
CTGGTCTATCCCAAAAACGAAAAAGACGATCTGACTGAAGCCGAAAAAGCTGTCCTGAAATCGATAAGTCAGCAAATCGA
ATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9415.66 Da
• Isoelectric Point: 4.3000

>AT201633 WP_074032216.1 NZ_CP074145:c65574-65323 [Serratia sp. JSRIV002]
MPNIIHSTMTASITELKTNPMATVNSGEGYPVAILNRNQPAFYCIPAALYEQMLEYIDDQELANLVKERSEQTLHDVNLD
RYV

Nucleotide

• Length: 252 bp

>AT201633 NZ_CP098699:c51681-51385 [Yersinia ruckeri]
ATGAAAACTGAACTGTTTAATGATCTCGTTGAAAGTATGCAACAGATGGTTGCTATTGAGAAAGGTACGCTCTCTGTTCC
AGCGGAAAACATCCATCGTCATCGACTTCCAGATGTAAAATCAATGCGTGAAGCGAGCGGTCTTAAGCAAAATGAATTTG
CGGATGTAGTGGGGGTTTCTGCTTCTCTGCTCCAGAGCTGGGAACAGCATCGTCGTATTCCATCAGGTTCATCTCTAAAG
TTGTTGATGATGATAGAGCGTGACCCAGCTGTTATAGACGCTTTACGAACGCTTTAG

Structures

Antitoxin

• AlphaFold DB: A0A1Q5UY56