Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE(toxin)
Location 5298433..5298955 Replicon chromosome
Accession NZ_CP074143
Organism Serratia sp. JSRIV002

Toxin (Protein)


Gene name relE Uniprot ID A0A0U4JRE1
Locus tag KGP26_RS24790 Protein ID WP_021806920.1
Coordinates 5298674..5298955 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0U4HY11
Locus tag KGP26_RS24785 Protein ID WP_021806919.1
Coordinates 5298433..5298684 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP26_RS24760 (KGP26_24675) 5293982..5294791 - 810 WP_059201891.1 SDR family oxidoreductase -
KGP26_RS24765 (KGP26_24680) 5294788..5295444 - 657 WP_021180630.1 iron-containing redox enzyme family protein -
KGP26_RS24770 (KGP26_24685) 5295441..5296880 - 1440 WP_094983167.1 AMP-dependent synthetase/ligase -
KGP26_RS24775 (KGP26_24690) 5296877..5297521 - 645 WP_021806917.1 thermostable hemolysin -
KGP26_RS24780 (KGP26_24695) 5297715..5298368 + 654 WP_021806918.1 Qnr family pentapeptide repeat protein -
KGP26_RS24785 (KGP26_24700) 5298433..5298684 + 252 WP_021806919.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KGP26_RS24790 (KGP26_24705) 5298674..5298955 + 282 WP_021806920.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KGP26_RS24795 (KGP26_24710) 5299124..5299759 + 636 WP_218520259.1 glutathione transferase -
KGP26_RS24800 (KGP26_24715) 5299870..5301324 - 1455 WP_021180637.1 NAD-dependent succinate-semialdehyde dehydrogenase -
KGP26_RS24805 (KGP26_24720) 5301337..5302602 - 1266 WP_223664712.1 4-aminobutyrate--2-oxoglutarate transaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10991.89 Da        Isoelectric Point: 10.6704

>T201629 WP_021806920.1 NZ_CP074143:5298674-5298955 [Serratia sp. JSRIV002]
MTYKLKFEKRALKEWEKLGYPVREQLKKKLAERLENPHVPASRLSGRPNRYKIKLRSSGYRLVYEVRDNEIVLLVIAVGK
RAGEEVYFAADKR

Download         Length: 282 bp

>T201629 NZ_CP098697:c2079030-2078937 [Yersinia ruckeri]
TAAGCCTGCATGAAATGCCAACTTTTAGCGCACGGCTCTATCCCAAGAGCCATTTCCCTGGACCGAATATAGGATTCGTA
TTCGGTCTTTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9243.37 Da        Isoelectric Point: 3.7947

>AT201629 WP_021806919.1 NZ_CP074143:5298433-5298684 [Serratia sp. JSRIV002]
MAFQILTTIAASITDLKKNPMGTVADGEGEAVAILNRNEPAFYCVPPELYAYYRELAEDAELNRIADERMEDAEFVSVDL
NDL

Download         Length: 252 bp

>AT201629 NZ_CP098697:2078933-2079079 [Yersinia ruckeri]
AGATAAAAAAAGACCGAATACGAATCCTATATTCGGTCCAGGGAAATGGCTCTTGGGATAGAGCCGTGCGCTAAAAGTTG
GCATTTCATGCAGGCTTATTAAGCCGTACCACTTAAGCGTAGTAGACGACCCACATTTTACCAATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U4JRE1

Antitoxin

Source ID Structure
AlphaFold DB A0A0U4HY11

References