Detailed information of TA system TA201627

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 5117021..5117811
• Replicon: chromosome
• Accession: NZ_CP074143
• Organism: Serratia sp. JSRIV002

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: KGP26_RS24070
• Protein ID: WP_223498453.1
• Coordinates: 5117021..5117356 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: KGP26_RS24075
• Protein ID: WP_223498454.1
• Coordinates: 5117434..5117811 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP26_RS24030 (KGP26_23945)	5112849..5113553	+	705	WP_223498446.1	transcriptional regulator	-
KGP26_RS24035 (KGP26_23950)	5113553..5114122	+	570	WP_223499718.1	hypothetical protein	-
KGP26_RS24040 (KGP26_23955)	5114161..5114613	+	453	WP_223498447.1	hypothetical protein	-
KGP26_RS24045 (KGP26_23960)	5114610..5115062	+	453	WP_223498448.1	IrmA family protein	-
KGP26_RS24050 (KGP26_23965)	5115208..5115642	+	435	WP_223498449.1	antirestriction protein	-
KGP26_RS24055 (KGP26_23970)	5115660..5116148	+	489	WP_223498450.1	DNA repair protein RadC	-
KGP26_RS24060 (KGP26_23975)	5116142..5116462	+	321	WP_223498451.1	DUF5983 family protein	-
KGP26_RS24065 (KGP26_23980)	5116526..5117008	+	483	WP_223498452.1	hypothetical protein	-
KGP26_RS24070 (KGP26_23985)	5117021..5117356	+	336	WP_223498453.1	TA system toxin CbtA family protein	Toxin
KGP26_RS24075 (KGP26_23990)	5117434..5117811	+	378	WP_223498454.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
KGP26_RS24080 (KGP26_23995)	5117890..5118747	+	858	WP_223498455.1	DUF4942 domain-containing protein	-
KGP26_RS24085 (KGP26_24000)	5118864..5119145	+	282	WP_223498456.1	ribbon-helix-helix domain-containing protein	-
KGP26_RS30275	5119285..5119419	+	135	WP_245398320.1	type II toxin-antitoxin system RelE/ParE family toxin	-
KGP26_RS24095 (KGP26_24010)	5119710..5120822	-	1113	WP_094981420.1	M20 family metallopeptidase	-
KGP26_RS24100 (KGP26_24015)	5120919..5121380	-	462	WP_037434993.1	YjiG family protein	-
KGP26_RS24105 (KGP26_24020)	5121397..5122131	-	735	WP_094981419.1	nucleoside recognition domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	blaSFC-1	-	5084942..5117811	32869

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (15-102)

Antitoxin

• Antitoxin CbeA (25-123)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12531.36 Da
• Isoelectric Point: 6.2133

>T201627 WP_223498453.1 NZ_CP074143:5117021-5117356 [Serratia sp. JSRIV002]
MKTMNKLPHTPSNASPAFLEYQQLLAWLLAHCYGLELNDTPYHDDQAITQQIEYGVTVRETVNELVEKFDLVRIDRPGFS
LMAQDPTLSAGDMLCARSARGLRSPVIRRLA

Nucleotide

• Length: 336 bp

>T201627 NZ_CP098697:c954783-954580 [Yersinia ruckeri]
ATGACCAAAACTGACTACCTAATGCGTTTAAGAAAATGCACAACAATTGACACACTAGAGCGTGTTATTGAAAAAAATAA
GTATGAGCTATCTGATGATGAACTAGAATTATTCTATTCTGCTGCGGATCATCGTCTAGCTGAACTTACCATGAATAAGT
TATACGATAAAATTCCTGCAACTGTCTGGCAACATGTGAAGTAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 13783.81 Da
• Isoelectric Point: 6.9474

>AT201627 WP_223498454.1 NZ_CP074143:5117434-5117811 [Serratia sp. JSRIV002]
MKEPVLNTDNNAAPLTDEDNIPSPVWGLHCAITPRLGARLVQKGNRLHFLPDRAGFVGMFSPDALKTLDRAFPVLIKLLE
ACLRSGELDQRRQHCVTVQHAGFTCEADTLGSFGHVYLAVYQTPT

Nucleotide

• Length: 378 bp

>AT201627 NZ_CP098697:c955203-954835 [Yersinia ruckeri]
ATGGATGAGTACTCACCTAAGCGACATGATATTGCTCAGTTGAAATTCTTATGTGAGAATTTGTATGATGAAGGTATCGC
CACATTGGGCGATAGCCACCACGGCTGGGTTAATGATCCAACCTCCGCGGTAAATCTCCAACTGAATGATTTAATCGAAC
ACATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACGCAGACGAAATCGATCTCTGCGAGTTGGTGGAGGAATATCTA
GACGATACATATACCTTGTTCAGCAGTTACGGAATCAATGATCCTGATTTACGCCGCTGGCAGAAAACAAAAGACCGATT
ATTCAGACTATTTTCAGGGGAATACCTATGTGCCCTGATGAAAAATTAA