Detailed information of TA system TA201626

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4827297..4827966
• Replicon: chromosome
• Accession: NZ_CP074143
• Organism: Serratia sp. JSRIV002

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: U2LMQ5
• Locus tag: KGP26_RS22675
• Protein ID: WP_021179806.1
• Coordinates: 4827297..4827719 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: U2M6Q5
• Locus tag: KGP26_RS22680
• Protein ID: WP_021179805.1
• Coordinates: 4827700..4827966 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP26_RS22655 (KGP26_22580)	4823141..4823659	+	519	WP_021179810.1	flavodoxin FldB	-
KGP26_RS22660 (KGP26_22585)	4823695..4825083	-	1389	WP_059201689.1	cell envelope integrity protein CreD	-
KGP26_RS22665 (KGP26_22590)	4825187..4826605	-	1419	WP_021806194.1	two-component system sensor histidine kinase CreC	-
KGP26_RS22670 (KGP26_22595)	4826602..4827297	-	696	WP_021806195.1	two-component system response regulator CreB	-
KGP26_RS22675 (KGP26_22600)	4827297..4827719	-	423	WP_021179806.1	protein YgfX	Toxin
KGP26_RS22680 (KGP26_22605)	4827700..4827966	-	267	WP_021179805.1	FAD assembly factor SdhE	Antitoxin
KGP26_RS22685 (KGP26_22610)	4828267..4829259	+	993	WP_223665683.1	tRNA-modifying protein YgfZ	-
KGP26_RS22690 (KGP26_22615)	4829299..4829796	-	498	WP_071681920.1	DUF2165 domain-containing protein	-
KGP26_RS22695 (KGP26_22620)	4830028..4830702	-	675	WP_037375710.1	hemolysin III family protein	-
KGP26_RS22700 (KGP26_22625)	4830939..4831547	+	609	WP_094981477.1	HD domain-containing protein	-
KGP26_RS22705 (KGP26_22630)	4831581..4832327	-	747	WP_115159283.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-130)

Antitoxin

• Flavinator of succinate dehydrogenase (7-78)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16466.40 Da
• Isoelectric Point: 10.6373

>T201626 WP_021179806.1 NZ_CP074143:c4827719-4827297 [Serratia sp. JSRIV002]
VALWRCDVRVSWRTQLVSLLTHGLLILLILIAPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLAERRIEWHGR
EWLMVNKPWMPGFGILLSLQQIDGKKRHRLWLASDSMSKADWRQLRQRLSFEPSATDEDV

Nucleotide

• Length: 423 bp

>T201626 NZ_CP098697:457650-458306 [Yersinia ruckeri]
GTGGCCTATGACTACAGCACTAGCCTCAACCCGGAAAAAGCCTTGATCTGGCGCATTGTCCATCGGGACAATATTCCGTG
GATACTGGACAACGGTCTGCACTGTGGCAACAGTCCGGTGCAGGCGGAAGACTGGATTAATATCGGTAACCCGGAGCTTA
TCGACAAACGTGCCGGACATCTGGTGCCAACCGGAATGCGGGGGACGCTGCATGACTATGTGCCGTTTTACTTTACTCCT
TTCTCGCCGATGCTGATGAATATCCGCAGCGGACGTGGCGGCATTAAGCAACGCCCCAATGAGGAGATCGTTATTCTGGT
CAGTAGCCTGCGAAACATGGTGGCGCAAAATGTCTCCTTCGTGTTTACCGATAGCCACGCATATTATAACCTGGCTAATT
ACTTTACCGAGCTGGACAGTCTGAACCAGATCGATTGGCCCATTCTACAAGCGCGGGATTTCCGTCGCGATCAGGACGAT
TTGGCCAAGTTCGAACGCTATCAGGCAGAGGCGTTAATTTGGAAGCACTGCCCAATAGCGCTGCTTGGCGGGATGATTTG
TTACAACGATGGCGTCAGGTTACAATTAGAGCAGTGGTTGTCGCAACGCAATCTGTCAATGCCCGTTCACGCGCGGGCTG
GGTGGTACTTCTCATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10363.93 Da
• Isoelectric Point: 5.5847

>AT201626 WP_021179805.1 NZ_CP074143:c4827966-4827700 [Serratia sp. JSRIV002]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDADKAVFIRLLECDDPDLFNWLMNHGAPQDQDLQRMVSLIQMRN
KARGPVAM

Nucleotide

• Length: 267 bp

>AT201626 NZ_CP098697:458303-459370 [Yersinia ruckeri]
ATGATTACATTTACACAAGGCAATTTACTGGATGCGCCCGTAGAAGCACTAGTGAATACGGTTAATACCGTCGGTGTCAT
GGGTAAAGGCATCGCGCTGATGTTCAAAGAGCGCTTCCCCGTCAATATGAAAGCCTATGCTCTCGCCTGCAAACATAAGC
AGGTAATGACAGGTAAAATGTTTATTACCGAAACCGGCGAACTGATGGGGCCTCGCTGGATTGTCAACTTCCCAACTAAA
CAACACTGGCGCGCAGACTCCCGCATGGAGTGGGTTGAAGACGGCTTGCAGGATTTACGCCGCTTTTTGATCGAAGAGAA
AGTGCAATCTATCGCCATTCCCCCACTGGGGGCGGGTAACGGCGGCCTGAATTGGTCGGACGTTCGGATGCGGATTGAAT
CTGCGCTGGGCGACCTTCAGGACACGGAAATTCTGATTTATGAGCCTACCGAAAAATACCAGAACGTCGCCAAGAGCACC
GGCGTAAAAAAGCTCACTCCCGCCAGAGCGCTGATTGCTGAACTGGTGCGCCGCTACTGGGTGCTGGGCATGGAGTGCAG
CCTGCTGGAAATCCAGAAGCTGGCATGGCTGTTACAACGCGCCATTGAACAGCATCAGCAGGAAGATGTGCTGAAACTGC
GGTTTGAGGCGCACTATTACGGCCCCTACGCCCCCAACCTTAACCATCTGCTTAACGCGCTAGATGGCACGTATCTGAAA
GCAGAGAAACGCATCCCGGACACCCAGCCGCTGGATGTGATCTGGTTTAATGATCAGGAAAAAGAACACATCAACCTCTG
GCTGAACAACGAGGCCAAAGAGTGGCTACCGGCGCTTGAGCAGGTCAGTCAGTTGATTGACGGCTTTGAATCGCCGTTTG
GTCTGGAGCTGCTGGCAACCGTTGACTGGCTGCTGACCCGAGGAAAATGCCAGCCCACGCTGGATTCCGTGAAAGAGGGG
CTGCACCAGTGGCCTGCGGGTGAACGCTGGGCCAGCCGTAAGATGAAGCTCTTTGACGACAAGAATCTGCAATTTGCCAT
CAACCGCGTGATGGAGTTCCATTGCTAA

Structures

Toxin

• AlphaFold DB: U2LMQ5

Antitoxin

• AlphaFold DB: U2M6Q5