Detailed information of TA system TA201625

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 4649034..4649677
• Replicon: chromosome
• Accession: NZ_CP074143
• Organism: Serratia sp. JSRIV002

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: KGP26_RS21890
• Protein ID: WP_059201614.1
• Coordinates: 4649034..4649450 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: KGP26_RS21895
• Protein ID: WP_059201615.1
• Coordinates: 4649447..4649677 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP26_RS21875 (KGP26_21805)	4644814..4645986	+	1173	WP_223664615.1	multidrug efflux MFS transporter periplasmic adaptor subunit EmrA	-
KGP26_RS21880 (KGP26_21810)	4646043..4647539	+	1497	WP_235050830.1	multidrug efflux MFS transporter permease subunit EmrB	-
KGP26_RS21885 (KGP26_21815)	4648057..4648791	-	735	WP_218518979.1	DUF3800 domain-containing protein	-
KGP26_RS21890 (KGP26_21820)	4649034..4649450	-	417	WP_059201614.1	PIN domain-containing protein	Toxin
KGP26_RS21895 (KGP26_21825)	4649447..4649677	-	231	WP_059201615.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
KGP26_RS21900 (KGP26_21830)	4649933..4651024	-	1092	WP_024484850.1	tRNA/rRNA methyltransferase	-
KGP26_RS21905 (KGP26_21835)	4651221..4651640	+	420	WP_094981235.1	thioredoxin TrxC	-
KGP26_RS21910 (KGP26_21840)	4651756..4652460	+	705	WP_021807596.1	tRNA-uridine aminocarboxypropyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-129)

Antitoxin

• SpoVT-AbrB domain (7-54)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15091.45 Da
• Isoelectric Point: 9.2042

>T201625 WP_059201614.1 NZ_CP074143:c4649450-4649034 [Serratia sp. JSRIV002]
MNKTYMLDTNICSFIMREQPEAVIRRLEQTVLRNHRIVVSAITYAEMRFGAIGKKASPRHVRLVDAFCSRLDAVLAWDRA
AVDATTNIKAALAAAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVTGLILEDWAK

Nucleotide

• Length: 417 bp

>T201625 NZ_CP098697:456005-456295 [Yersinia ruckeri]
ATGACCTTTAATATCGACTTTGACGAACGGGCATTAAAAGAATGGCACAAACTAGATAAAACTATCCGAGAGCAATTTAA
AAAGAAACTAAGAAAATTACAGGAAAATCCCTATATTGAGTCAGCACGTTTGCACGGTGATCTGGCTGGTTGTTTCAAAA
TAAAATTACGCGCATCTGGCTTTCGGTTGATTTACCAAGTTATCGATGAGGAGATTGTGATTTTGATCGTTGCTGTTGGT
AAACGGGAAGATGAAAAAGCTTATGATCTTGCCAAGAAGCGAATCCAATAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8816.02 Da
• Isoelectric Point: 4.3775

>AT201625 WP_059201615.1 NZ_CP074143:c4649677-4649447 [Serratia sp. JSRIV002]
MRIVSVFKNGNNRAIRLPRDMDFDGVSELEIIREGDSIILRPIRPTWGSFLQEEKADADFMMEREGIVSDEGRFEL

Nucleotide

• Length: 231 bp

>AT201625 NZ_CP098697:455761-456015 [Yersinia ruckeri]
ATGAGTACTATCCAAATTCGTGTGGATGATGAACTGAAGAAAAGTGCATATCAGGCGTTTGAAAAACTGAATCTTTCGCC
TTCTGATGCACTACGCCTGTTCCTACGTTATGTTGCAGAGAACGAAAAGCTGCCTTTTTCAGAAGTATCCGTCATGGTCA
GTAATCAAGATGAGGATGCTGATATTTTGGCTGTTGTCCGTGAACGTTTGAAAAATCCTGCAAAGCGTATCAGAGTAAAT
ATTGATGACCTTTAA