201624

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4422440..4423096 Replicon chromosome
Accession NZ_CP074143
Organism Serratia sp. JSRIV002

Toxin (Protein)


Gene name vapC Uniprot ID A0A0U4J950
Locus tag KGP26_RS20820 Protein ID WP_021807143.1
Coordinates 4422440..4422829 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U2NVJ4
Locus tag KGP26_RS20825 Protein ID WP_021178792.1
Coordinates 4422833..4423096 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP26_RS20805 (KGP26_20735) 4418895..4420340 + 1446 WP_021807140.1 MFS transporter -
KGP26_RS20810 (KGP26_20740) 4420337..4421707 + 1371 WP_179247664.1 two-component system sensor histidine kinase BaeS -
KGP26_RS20815 (KGP26_20745) 4421720..4422436 + 717 WP_021807142.1 two-component system response regulator BaeR -
KGP26_RS20820 (KGP26_20750) 4422440..4422829 - 390 WP_021807143.1 type II toxin-antitoxin system VapC family toxin Toxin
KGP26_RS20825 (KGP26_20755) 4422833..4423096 - 264 WP_021178792.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KGP26_RS20830 (KGP26_20760) 4423444..4423782 + 339 WP_021178793.1 YegP family protein -
KGP26_RS20835 (KGP26_20765) 4423963..4425315 + 1353 WP_021178794.1 tRNA 5-hydroxyuridine modification protein YegQ -
KGP26_RS20840 (KGP26_20770) 4425852..4426751 + 900 WP_021807144.1 lipid kinase YegS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14260.54 Da        Isoelectric Point: 7.8799

>T201624 WP_021807143.1 NZ_CP074143:c4422829-4422440 [Serratia sp. JSRIV002]
MYMFDTNTVSQLFRQHPRLLAAMGRVPPSSVCISSITQAELLYGVAKRQNKALKQTVMMFLDAVTVYSWDSAAAHCYGVM
RASMEKQGRPMGALDQLIAAHAVSRGATIVTSDRAFTMVAELEVEDWTL

Download         Length: 390 bp

>T201624 NZ_CP098696:12721-13044 [Yersinia ruckeri]
ATGGAGTATCTAGAATTCATTGAGACCCCCGTATTTAGCAGGCGAAGAGCTGAACTGCTGCCAGATGATGACTTCAGAGC
TTTACAGGAGCATCTTCTTAAAAACCATGATCTTGGCGACACAATCAGTAAAACAGGTGGATGTAAGAAAATCCGCTGGA
GTCGCGAAGGCATGGGGAAGCGGGGGGGAGTAAGAGTTATTTATTACGTCATAACCAAATCGGGACGCCTTTATCTGCTA
CTGGTCTATCCCAAAAACGAAAAAGACGATCTGACTGAAGCCGAAAAAGCTGTCCTGAAATCGATAAGTCAGCAAATCGA
ATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10157.53 Da        Isoelectric Point: 4.8232

>AT201624 WP_021178792.1 NZ_CP074143:c4423096-4422833 [Serratia sp. JSRIV002]
MERVAKLFKNGRNQAVRLPVEFEFDVDQVYIRRDEQGNVILSKHPMKLDSWQPLLTMLQNVAVPADFLTADDRQQGVAER
DPFKEEQ

Download         Length: 264 bp

>AT201624 NZ_CP098696:13090-13386 [Yersinia ruckeri]
ATGAAAACTGAACTGTTTAATGATCTCGTTGAAAGTATGCAACAGATGGTTGCTATTGAGAAAGGTACGCTCTCTGTTCC
AGCGGAAAACATCCATCGTCATCGACTTCCAGATGTAAAATCAATGCGTGAAGCGAGCGGTCTTAAGCAAAATGAATTTG
CGGATGTAGTGGGGGTTTCTGCTTCTCTGCTCCAGAGCTGGGAACAGCATCGTCGTATTCCATCAGGTTCATCTCTAAAG
TTGTTGATGATGATAGAGCGTGACCCAGCTGTTATAGACGCTTTACGAACGCTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U4J950

Antitoxin

Source ID Structure
AlphaFold DB U2NVJ4

References