201614

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2329393..2330175 Replicon chromosome
Accession NZ_CP074143
Organism Serratia sp. JSRIV002

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag KGP26_RS10860 Protein ID WP_223497969.1
Coordinates 2329840..2330175 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag KGP26_RS10855 Protein ID WP_223497970.1
Coordinates 2329393..2329761 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP26_RS10830 (KGP26_10805) 2325719..2326339 - 621 WP_021804844.1 4Fe-4S dicluster domain-containing protein -
KGP26_RS10835 (KGP26_10810) 2326371..2326913 - 543 WP_094982349.1 electron transport protein HydN -
KGP26_RS10840 (KGP26_10815) 2327706..2328017 - 312 WP_223497973.1 putative addiction module antidote protein -
KGP26_RS10845 (KGP26_10820) 2328058..2328339 - 282 WP_223497972.1 type II toxin-antitoxin system RelE/ParE family toxin -
KGP26_RS10850 (KGP26_10825) 2328460..2329317 - 858 WP_223497971.1 DUF4942 domain-containing protein -
KGP26_RS10855 (KGP26_10830) 2329393..2329761 - 369 WP_223497970.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KGP26_RS10860 (KGP26_10835) 2329840..2330175 - 336 WP_223497969.1 TA system toxin CbtA family protein Toxin
KGP26_RS10865 (KGP26_10840) 2330188..2330670 - 483 WP_223497968.1 hypothetical protein -
KGP26_RS10870 (KGP26_10845) 2330732..2331052 - 321 WP_223497967.1 DUF5983 family protein -
KGP26_RS10875 (KGP26_10850) 2331049..2331426 - 378 WP_223497966.1 hypothetical protein -
KGP26_RS10880 (KGP26_10855) 2331465..2331953 - 489 WP_223497965.1 DNA repair protein RadC -
KGP26_RS10885 (KGP26_10860) 2331968..2332420 - 453 Protein_2118 antirestriction protein -
KGP26_RS10890 (KGP26_10865) 2332539..2332787 - 249 WP_223497964.1 hypothetical protein -
KGP26_RS10895 (KGP26_10870) 2332787..2333611 - 825 WP_223497963.1 DUF932 domain-containing protein -
KGP26_RS10900 (KGP26_10875) 2333783..2334022 - 240 WP_223497962.1 hypothetical protein -
KGP26_RS10905 (KGP26_10880) 2334025..2334243 - 219 WP_223497961.1 hypothetical protein -
KGP26_RS10910 (KGP26_10885) 2334306..2335010 - 705 WP_223497960.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(20-103)

Antitoxin

Antitoxin CbeA

(17-115)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12501.29 Da        Isoelectric Point: 6.6384

>T201614 WP_223497969.1 NZ_CP074143:c2330175-2329840 [Serratia sp. JSRIV002]
MKTINKLPHTPTHANPTFIEYQQLLAWLLGHCYGLELNDTPYHDDQAIAQQIEHGITVRETVNELVEKFDLVRIDRPGFS
LMAQDPTLSGGDLLRARSALGLRSPAIRRLA

Download         Length: 336 bp

>T201614 NZ_CP098694:c3123557-3122607 [Yersinia ruckeri]
ATGGATGATTTAACAAAGCTATTCCCAGATGTTGCTGATGCTCTGGGCATTGAATCTGTTTCAATTGTAGAAAAAGATTA
TTACATCGTTGAGTTATTACGATTGCTCCAGCCTATGGACTTTGACACGCATCAGCTGGTTTTTGCCGGTGGAACAGCAT
TGTCAAAAGCGGGTATATCTTTGAACAGGATGTCGGAGGACGTGGACATTAAGCTTGTACCTCTCGCCGGTTTTTCCCAG
CAATATTCCAGAGGTCAGCGTAAAAGCATCCGTAAGGGTATTATTCAGACCATTATCGAGACGGTTGCCGCCTCAGGTAC
GTTTCTCCTGGATGAAGAGTATCCAAAGGTTACTCGTGATGAATACCGTTATAATGAAATTCCGGTGCGTTACCCGCAGG
AATATGTACAAGTTCCCTGCTTAAGGCCATTTATCAAACTGGAACTGATGGAAACGGATTTGCTTGAGGCTGCGGAAAAT
CGTGCTATTAGCTCCTTGGTAATGGATCTAACAAAGAAGGGCGAAGTAGTGAGGGCTTTCCCTTGCGCAACCATCGGTAG
CACGCAGGCTGAAAAACTGATCTCGATGATGCGCAGAACGGCTGCAAGTATGCGTGATGTGGAACGTGCAGTGGATGAAT
CACTGGTACGTCATATCTACGATAATTTTTGTATTGTTAGAGAAAAAGGTGCTGACGTTCCTGTTTTGAAGCAATTCGTG
CAGGAATGCATTGAACAGGATATTGAACGTTACGGTGCTCAGTACCCTGAATTCTGCGAGTCGCCTGTCGAAGAACTAAA
AATGGGGCTGGAAGAACTCGTGAGCAATCCTGTTTATAAGGAACGCTATCTGCAATTCGTCACACCAATGGTCTTCGGTG
AAAGCCACGTTTCATGGGAAGAGGCCTATGCCTGTTTTCGCAAAACGGTATTGGATGTGGTTGATGCATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13401.97 Da        Isoelectric Point: 6.3645

>AT201614 WP_223497970.1 NZ_CP074143:c2329761-2329393 [Serratia sp. JSRIV002]
MKDSDTDNHEDSTPSPIWGLHCAITPRLGARLVQQGNRLHFLVDRAGLVGTFSPNDLKGLNSAFPVLIEQLETCLRSGEL
DQRRQHCVTVQHAGFTCQADTLGSFGHVYIAVYQTAQHTSGE

Download         Length: 369 bp

>AT201614 NZ_CP098694:c3123945-3123550 [Yersinia ruckeri]
ATGACTACAAAAGCTCGTATTCAGTTACGACTGAAACGCTCAAAGCGTTATGTTTTCACTCGTGACGATTTCAAAGATCT
TGCTGGCTACGACCAAATTGGTAGAGCACTGCGTGAACTGGTGAAGGAAGGGCAGCTGCTGAAAGTAGGCTATGGCGTCT
ACACCAAAGCGCGGCAAAATGTGATTACCGGTAAGTTGATGCCTGCGGCTCCCGGAGGTTCGGCTGCGGTAGTGATTGAG
GCGTTGGAACGTCTGAAAGTGGATTACCGCTTGGTTGGAGCAACAAGCGCCTATAATAGCGGTAAATCCACTCAGATCCC
CGCTTCACTGGAAATCAAAACCTCACCACGTTTTAAGAGGACATTGTCAGTAGGGAGCAGCAAACTAAATGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References