Detailed information of TA system TA201612

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1474444..1475092
• Replicon: chromosome
• Accession: NZ_CP074143
• Organism: Serratia sp. JSRIV002

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: KGP26_RS06695
• Protein ID: WP_094981177.1
• Coordinates: 1474889..1475092 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: U2LL75
• Locus tag: KGP26_RS06690
• Protein ID: WP_021180099.1
• Coordinates: 1474444..1474851 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP26_RS06675 (KGP26_06665)	1469815..1470294	-	480	WP_094981179.1	Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK	-
KGP26_RS06680 (KGP26_06670)	1470516..1471319	-	804	WP_071682995.1	TraB/GumN family protein	-
KGP26_RS06685 (KGP26_06675)	1471469..1474180	-	2712	WP_094981178.1	copper-exporting P-type ATPase CopA	-
KGP26_RS06690 (KGP26_06680)	1474444..1474851	-	408	WP_021180099.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KGP26_RS06695 (KGP26_06685)	1474889..1475092	-	204	WP_094981177.1	type II toxin-antitoxin system HicA family toxin	Toxin
KGP26_RS06700 (KGP26_06690)	1475317..1475718	+	402	WP_223665178.1	Cu(I)-responsive transcriptional regulator	-
KGP26_RS06705 (KGP26_06695)	1475715..1476173	-	459	WP_223500987.1	NfeD family protein	-
KGP26_RS06710 (KGP26_06700)	1476176..1477081	-	906	WP_021180096.1	SPFH domain-containing protein	-
KGP26_RS06715 (KGP26_06705)	1477265..1478188	-	924	WP_021180095.1	HTH-type transcriptional activator AllS	-
KGP26_RS06720 (KGP26_06710)	1478541..1479032	+	492	WP_037375311.1	ureidoglycolate lyase	-
KGP26_RS06725 (KGP26_06715)	1479102..1479917	+	816	WP_021805438.1	HTH-type transcriptional repressor AllR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7370.83 Da
• Isoelectric Point: 11.5784

>T201612 WP_094981177.1 NZ_CP074143:c1475092-1474889 [Serratia sp. JSRIV002]
MESGELIKRLQADGWIIRKSRGKKATGSHVTMTKPGVAKIITIPHPKKDPSKGILRQVQQISGLKLI

Nucleotide

• Length: 204 bp

>T201612 NZ_CP098694:c1703822-1703364 [Yersinia ruckeri]
GTGATGCTCTACCGGATAGTTCACAACCGTTACCTGGCAACGGCCTGGACCGGATATGGCGCAGAAACCTATGGTGGCCG
CTGGAATCATAAAGGCCATGCGGCGATTTATCTGGCCAGTAGCGTTTCTCTGGCGATGCTCGAAACACTGGTGCATGTAG
AAGATAGCGCGACGCTGAACGATTTTAATCTATTTCAGATAACCATTCCCGATAATGCAATTATGGTACTGCAACAGCAA
GATTGGCCACGTGGGTGGCGAGATGACCCCACCCCCGTGGCTACCATGGACATCGGCACCGAATGGATTGGTTCAGCATC
ATCTGTCGGTCTGCTGGTACCATCCACGTTAGTCCCTTTGGAAAGAAATATGTTGGTGAATCCTAAACACCGCGATTTCG
CCTCGTGCCTGAAAAGCATCCATCCACTGACGTTCAGTTTTGATCCTCGTCTAAAGTAA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 15337.37 Da
• Isoelectric Point: 4.4886

>AT201612 WP_021180099.1 NZ_CP074143:c1474851-1474444 [Serratia sp. JSRIV002]
MIYPIFIFKTSEGFDGYFPDVEGCFFAGEKMSDIPKNAEEAFGVHMEALIEEGFPVPAAPQDPQSYLNDSRLREDGGILG
FVEIDPAKYEDKSIKFNLTMPRNLLTAIDKYIETTRGYKNRSQFLAELAREKISH

Nucleotide

• Length: 408 bp

>AT201612 NZ_CP098694:c1704282-1703836 [Yersinia ruckeri]
ATGAGAACTTATCACCCAAGCCCGATGGCCAAAGTCAGCGCACTATGGCGTGAGATTGGTCTACCCGCCAGTCGTGGCAC
CGCTTTGGTGGACAGCATAAAACTGGGATTTACTGTGGATGTGATCGACACTATACATTTATGGGCTGATATGCCTAAAT
CTGAAATATTACGCGCTACGGGTATTCCGAGCCGCAGTCTGACGCGCCGTCGTACCCATGATGGGCGTTTTACCCCGGAA
GAAAGCGAACGTATTGCACGGTTTGTCCGGGTTATGGATGCGGCGGTAGATTTGTTCGGTGGTGACCGCACCAAAGCAAC
CGCATGGATGTCGATGCCGGTCAAAGGGCTGGGTAATCGAACGCCCGATTCACTGCTGGAAACCGAAACCGGTGCGTTGG
AAATCTGCGACCTGATTGGTCGTCTCGAACATGGGGTCTTTTCGTGA

Structures

Antitoxin

• AlphaFold DB: U2LL75