201611

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1437717..1438339 Replicon chromosome
Accession NZ_CP074143
Organism Serratia sp. JSRIV002

Toxin (Protein)


Gene name Hha Uniprot ID U2M374
Locus tag KGP26_RS06530 Protein ID WP_021180142.1
Coordinates 1437717..1437920 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID U2NAN4
Locus tag KGP26_RS06535 Protein ID WP_021180141.1
Coordinates 1437971..1438339 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP26_RS06505 (KGP26_06495) 1433547..1434035 + 489 WP_021180151.1 YbaY family lipoprotein -
KGP26_RS06510 (KGP26_06500) 1434089..1434403 - 315 WP_021180150.1 MGMT family protein -
KGP26_RS06520 (KGP26_06510) 1434784..1436571 - 1788 WP_094981190.1 adenine deaminase C-terminal domain-containing protein -
KGP26_RS06525 (KGP26_06515) 1436709..1437635 + 927 WP_059200026.1 LysR family transcriptional regulator -
KGP26_RS06530 (KGP26_06520) 1437717..1437920 - 204 WP_021180142.1 HHA domain-containing protein Toxin
KGP26_RS06535 (KGP26_06525) 1437971..1438339 - 369 WP_021180141.1 Hha toxicity modulator TomB Antitoxin
KGP26_RS06540 (KGP26_06530) 1438496..1438849 - 354 WP_094981218.1 hypothetical protein -
KGP26_RS06545 (KGP26_06535) 1439229..1439921 + 693 WP_223665172.1 ABC transporter ATP-binding protein -
KGP26_RS06550 (KGP26_06540) 1439921..1440778 + 858 WP_094981189.1 metal ABC transporter permease -
KGP26_RS06555 (KGP26_06545) 1440804..1441682 + 879 WP_059200029.1 zinc ABC transporter substrate-binding protein -
KGP26_RS06560 (KGP26_06550) 1441790..1441930 - 141 WP_021805462.1 type B 50S ribosomal protein L36 -
KGP26_RS06565 (KGP26_06555) 1441943..1442200 - 258 WP_223665173.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8099.48 Da        Isoelectric Point: 6.9770

>T201611 WP_021180142.1 NZ_CP074143:c1437920-1437717 [Serratia sp. JSRIV002]
MTKIDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVAVWKFVR

Download         Length: 204 bp

>T201611 NZ_CP098694:1560171-1560264 [Yersinia ruckeri]
TAAGCCTGCATGAAATGCCAACTTTTAGCGCACGGCTCTATCCCAAGAGCCATTTCCCTGGACCGAATATAGGAATCGTA
TTCGGTCTTTTTTT

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14097.78 Da        Isoelectric Point: 4.5140

>AT201611 WP_021180141.1 NZ_CP074143:c1438339-1437971 [Serratia sp. JSRIV002]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNELIEHIASFVMSFKIKYMDEGDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARTFRLFSGEGVCTTMKT

Download         Length: 369 bp

>AT201611 NZ_CP098694:c1560268-1560122 [Yersinia ruckeri]
AGATAAAAAAAGACCGAATACGATTCCTATATTCGGTCCAGGGAAATGGCTCTTGGGATAGAGCCGTGCGCTAAAAGTTG
GCATTTCATGCAGGCTTATTAAGCCGTACCACTTAAGCGTAGTAGACGACCCACATTTTACCAATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2M374

Antitoxin

Source ID Structure
AlphaFold DB U2NAN4

References