Detailed information of TA system TA201610

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 1247718..1248274
• Replicon: chromosome
• Accession: NZ_CP074143
• Organism: Serratia sp. JSRIV002

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: KGP26_RS05645
• Protein ID: WP_021805609.1
• Coordinates: 1247718..1248008 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U2MX00
• Locus tag: KGP26_RS05650
• Protein ID: WP_021181943.1
• Coordinates: 1247996..1248274 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP26_RS05625 (KGP26_05615)	1242804..1243754	-	951	WP_094983017.1	GNAT family N-acetyltransferase	-
KGP26_RS05630 (KGP26_05620)	1243751..1245481	-	1731	WP_094983018.1	IucA/IucC family protein	-
KGP26_RS05635 (KGP26_05625)	1245615..1246841	+	1227	WP_094983019.1	MFS transporter	-
KGP26_RS05640 (KGP26_05630)	1246843..1247721	+	879	WP_179249125.1	siderophore-interacting protein	-
KGP26_RS05645 (KGP26_05635)	1247718..1248008	-	291	WP_021805609.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KGP26_RS05650 (KGP26_05640)	1247996..1248274	-	279	WP_021181943.1	CopG family ribbon-helix-helix protein	Antitoxin
KGP26_RS05655 (KGP26_05645)	1248441..1249280	+	840	WP_021181942.1	MurR/RpiR family transcriptional regulator	-
KGP26_RS05660 (KGP26_05650)	1249472..1250713	+	1242	WP_223665137.1	alanine--glyoxylate aminotransferase family protein	-
KGP26_RS05665 (KGP26_05655)	1250713..1252032	+	1320	WP_094983022.1	allantoate amidohydrolase	-
KGP26_RS05670 (KGP26_05660)	1251975..1252748	-	774	WP_021805606.1	amidohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10910.59 Da
• Isoelectric Point: 9.3939

>T201610 WP_021805609.1 NZ_CP074143:c1248008-1247718 [Serratia sp. JSRIV002]
VSQLKWSPAALADVQRLYLFLAEKDSDTAKRAISKIRRSVKILALQPQVGRPVEEMPHQYREWPIEFGSSGYVVLYHFDG
TVAVLLAVRHQLEAGY

Nucleotide

• Length: 291 bp

>T201610 NZ_CP098694:740725-741147 [Yersinia ruckeri]
GTGGCCCAGTGGCGATGTGATCTGCGGGTTTCATGGCGCACCCAACTTTTCTCACTATTGGTACACGGTGTTCTGGTATT
ACTGACACTGGTGGTACCTTGGCCTGACGGATTTACTCCGCTATGGCTTATATTGCTGACGCTGGTGGTGTTTGAATGCA
TTCGCAGCCAGAAGAACATTACCTCTCGACAGGGAGAGATCCGGCTTAAAGCGGGAAATCTGTTGATTTGGAAGTGGCAA
GAGTGGACGTTGGTGCGGCCGCCGTGGATTACCCGCTACGGCGTATTATTATCGTTACAAGGCGCTGGCAGCCGCCGCCG
AAAACGTATTTGGCTAGCCTCCGACAGCATGTCGGAAGAAAAATGGCGCGAGTTGTGTCTGATATTACGACATACTTTTG
ATTCTGCGGCAGGCCGTGAGTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10862.10 Da
• Isoelectric Point: 4.7997

>AT201610 WP_021181943.1 NZ_CP074143:c1248274-1247996 [Serratia sp. JSRIV002]
MATATSIKIDEELKLRVQQIALARQRTAHWIMREAIREYVEREEKREALRNDALRAWETYQADGKHLTQEEADNWLANLE
KGDDTEIPECHN

Nucleotide

• Length: 279 bp

>AT201610 NZ_CP098694:740478-740744 [Yersinia ruckeri]
ATGGAAATTGATAACAAAGCCCGAATCCATTGGGCATGCCGCCGGGGTATGCGTGAACTGGATATCTCCATAATGCCATT
TTTCGAACATGAATATGACACGCTAAACGATAATGATAAGCGCGTATTTATCCGCTTGCTGACGAGTGATGATCCTGATT
TATTCAATTGGTTGATGAACCACGGCGAGCCGCAGGATAGCGAACTGAAACGAATGGTTAAACTGATTCAGACACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: U2MX00