Detailed information of TA system TA201608

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 681504..682066
• Replicon: chromosome
• Accession: NZ_CP074143
• Organism: Serratia sp. JSRIV002

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: A0A0F7HBD7
• Locus tag: KGP26_RS03045
• Protein ID: WP_024486364.1
• Coordinates: 681504..681821 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: KGP26_RS03050
• Protein ID: WP_218519922.1
• Coordinates: 681821..682066 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP26_RS03030 (KGP26_03025)	677201..678295	+	1095	WP_065684324.1	LPS export ABC transporter permease LptF	-
KGP26_RS03035 (KGP26_03030)	678295..679365	+	1071	WP_021807815.1	LPS export ABC transporter permease LptG	-
KGP26_RS03040 (KGP26_03035)	679467..681263	-	1797	WP_209554795.1	glycosyl hydrolase family 28 protein	-
KGP26_RS03045 (KGP26_03040)	681504..681821	-	318	WP_024486364.1	CcdB family protein	Toxin
KGP26_RS03050 (KGP26_03045)	681821..682066	-	246	WP_218519922.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
KGP26_RS03055 (KGP26_03050)	682156..682485	-	330	WP_021179117.1	multidrug efflux SMR transporter	-
KGP26_RS03060 (KGP26_03055)	682497..682856	-	360	WP_021179118.1	multidrug efflux SMR transporter	-
KGP26_RS03065 (KGP26_03060)	682911..683579	-	669	WP_223664997.1	hypothetical protein	-
KGP26_RS03070 (KGP26_03065)	683590..684225	-	636	WP_094982215.1	phosphate propanoyltransferase	-
KGP26_RS03075 (KGP26_03070)	684261..684695	-	435	WP_223500809.1	BMC domain-containing protein	-
KGP26_RS03080 (KGP26_03075)	684706..685656	-	951	WP_021807820.1	choline TMA-lyase-activating enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (3-104)

Antitoxin

• Post-segregation antitoxin CcdA (9-75)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 11652.62 Da
• Isoelectric Point: 8.0501

>T201608 WP_024486364.1 NZ_CP074143:c681821-681504 [Serratia sp. JSRIV002]
MKQFSVYKNQSKNKKAYPFFIVVQSDLLDHLSTRLVMPLALKHATNSQVKALTPVLSVDQQDYVILTSLLTTTDVKNLNA
DCLVTNAAHLRDELVAAIDLLVLGI

Nucleotide

• Length: 318 bp

>T201608 NZ_CP098692:c68576-68253 [Yersinia ruckeri]
ATGGAGTATCTAGAATTCATTGAGACCCCCGTATTTAGCAGGCGAAGAGCTGAACTGCTGCCAGATGATGACTTCAGAGC
TTTACAGGAGCATCTTCTTAAAAACCATGATCTTGGCGACACAATCAGTAAAACAGGTGGATGTAAGAAAATCCGCTGGA
GTCGCGAAGGCATGGGGAAGCGGGGGGGAGTAAGAGTTATTTATTACGTCATAACCAAATCGGGACGCCTTTATCTGCTA
CTGGTCTATCCCAAAAACGAAAAAGACGATCTGACTGAAGCCGAAAAAGCTGTCCTGAAATCGATAAGTCAGCAAATCGA
ATAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8902.14 Da
• Isoelectric Point: 5.0644

>AT201608 WP_218519922.1 NZ_CP074143:c682066-681821 [Serratia sp. JSRIV002]
MGTVSVIKKRNTNVYLSVDLIEKAKALDLNLSATLNHALELAVKKGQRERWLAENRAGLEALNGFVEENGLFSDDADFGV
L

Nucleotide

• Length: 246 bp

>AT201608 NZ_CP098692:c68207-67911 [Yersinia ruckeri]
ATGAAAACTGAACTGTTTAATGATCTCGTTGAAAGTATGCAACAGATGGTTGCTATTGAGAAAGGTACGCTCTCTGTTCC
AGCGGAAAACATCCATCGTCATCGACTTCCAGATGTAAAATCAATGCGTGAAGCGAGCGGTCTTAAGCAAAATGAATTTG
CGGATGTAGTGGGGGTTTCTGCTTCTCTGCTCCAGAGCTGGGAACAGCATCGTCGTATTCCATCAGGTTCATCTCTAAAG
TTGTTGATGATGATAGAGCGTGACCCAGCTGTTATAGACGCTTTACGAACGCTTTAG

Structures

Toxin

• AlphaFold DB: A0A0F7HBD7