Detailed information of TA system TA201607

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/-
• Location: 634688..635190
• Replicon: chromosome
• Accession: NZ_CP074143
• Organism: Serratia sp. JSRIV002

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KGP26_RS02860
• Protein ID: WP_094981870.1
• Coordinates: 634984..635190 (+)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U2NJB3
• Locus tag: KGP26_RS02855
• Protein ID: WP_021179086.1
• Coordinates: 634688..634975 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP26_RS02825 (KGP26_02820)	629924..630712	-	789	WP_024483394.1	phosphonate C-P lyase system protein PhnK	-
KGP26_RS02830 (KGP26_02825)	630712..631563	-	852	WP_021179081.1	alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase PhnJ	-
KGP26_RS02835 (KGP26_02830)	631556..632641	-	1086	WP_094981873.1	carbon-phosphorus lyase complex subunit PhnI	-
KGP26_RS02840 (KGP26_02835)	632641..633222	-	582	WP_223664987.1	phosphonate C-P lyase system protein PhnH	-
KGP26_RS02845 (KGP26_02840)	633226..633669	-	444	WP_059199561.1	phosphonate C-P lyase system protein PhnG	-
KGP26_RS02850 (KGP26_02845)	633670..634398	-	729	WP_021807487.1	phosphonate metabolism transcriptional regulator PhnF	-
KGP26_RS02855 (KGP26_02850)	634688..634975	+	288	WP_021179086.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KGP26_RS02860 (KGP26_02855)	634984..635190	+	207	WP_094981870.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KGP26_RS02865 (KGP26_02860)	635327..635803	+	477	WP_094981869.1	Hcp family type VI secretion system effector	-
KGP26_RS02870 (KGP26_02865)	636059..636766	-	708	WP_094981867.1	hypothetical protein	-
KGP26_RS02875 (KGP26_02870)	637238..637510	+	273	Protein_548	tyrosine-type recombinase/integrase	-
KGP26_RS02880 (KGP26_02875)	637516..637980	-	465	WP_021807485.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
KGP26_RS02885 (KGP26_02880)	638333..639484	-	1152	Protein_550	IS481 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	638330..639472	1142

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-51)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-44)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7858.83 Da
• Isoelectric Point: 3.8209

>T201607 WP_094981870.1 NZ_CP074143:634984-635190 [Serratia sp. JSRIV002]
MRIEWDDVALQDRERIFEFLYPLNSLAAEQVDDEIELAVESLLENPEMGRLTSLASFVSAQLFNNKNI

Nucleotide

• Length: 207 bp

>T201607 NZ_CP098691:c3050318-3049896 [Yersinia ruckeri]
GTGGCCCAGTGGCGATGTGATCTGCGGGTTTCATGGCGCACCCAACTTTTCTCACTATTGGTACACGGTGTTCTGGTATT
ACTGACACTGGTGGTACCTTGGCCTGACGGATTTACTCCGCTATGGCTTATATTGCTGACGCTGGTGGTGTTTGAATGCA
TTCGCAGCCAGAAGAACATTACCTCTCGACAGGGAGAGATCCGGCTTAAAGCGGGAAATCTGTTGATTTGGAAGTGGCAA
GAGTGGACGTTGGTGCGGCCGCCGTGGATTACCCGCTACGGCGTATTATTATCGTTACAAGGCGCTGGCAGCCGCCGCCG
AAAACGTATTTGGCTAGCCTCCGACAGCATGTCGGAAGAAAAATGGCGCGAGTTGTGTCTGATATTACGACATACTTTTG
ATTCTGCGGCAGGCCGTGAGTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10957.35 Da
• Isoelectric Point: 8.0314

>AT201607 WP_021179086.1 NZ_CP074143:634688-634975 [Serratia sp. JSRIV002]
MESRIQFRIENETKLLAQKAAEAKGTTLSEACRRLAQQMADDQRAAEEHENWLKDKVDAAFARLHEGEAVYLTQRQAEER
MSDFKAKVRAKYATK

Nucleotide

• Length: 288 bp

>AT201607 NZ_CP098691:c3050565-3050299 [Yersinia ruckeri]
ATGGAAATTGATAACAAAGCCCGAATCCATTGGGCATGCCGCCGGGGTATGCGTGAACTGGATATCTCCATAATGCCATT
TTTCGAACATGAATATGACACGCTAAACGATAATGATAAGCGCGTATTTATCCGCTTGCTGACGAGTGATGATCCTGATT
TATTCAATTGGTTGATGAACCACGGCGAGCCGCAGGATAGCGAACTGAAACGAATGGTTAAACTGATTCAGACACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: U2NJB3