Detailed information of TA system TA201606

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 471382..472160
• Replicon: chromosome
• Accession: NZ_CP074143
• Organism: Serratia sp. JSRIV002

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: KGP26_RS02070
• Protein ID: WP_223664959.1
• Coordinates: 471382..471870 (-)
• Length: 163 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: -
• Locus tag: KGP26_RS02075
• Protein ID: WP_223664960.1
• Coordinates: 471867..472160 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP26_RS02045 (KGP26_02040)	466622..467938	+	1317	WP_021808073.1	glutamate/aspartate:proton symporter GltP	-
KGP26_RS02050 (KGP26_02045)	468055..469317	+	1263	WP_223664956.1	hypothetical protein	-
KGP26_RS02055 (KGP26_02050)	469387..469920	-	534	WP_223664957.1	metal-dependent hydrolase	-
KGP26_RS02060 (KGP26_02055)	469957..470580	-	624	WP_223664958.1	TetR/AcrR family transcriptional regulator	-
KGP26_RS02065 (KGP26_02060)	470690..471292	+	603	WP_218519966.1	NAD(P)H-dependent oxidoreductase	-
KGP26_RS02070 (KGP26_02065)	471382..471870	-	489	WP_223664959.1	GNAT family N-acetyltransferase	Toxin
KGP26_RS02075 (KGP26_02070)	471867..472160	-	294	WP_223664960.1	DUF1778 domain-containing protein	Antitoxin
KGP26_RS02080 (KGP26_02075)	472605..473708	-	1104	WP_223664961.1	hypothetical protein	-
KGP26_RS02085 (KGP26_02080)	473902..474120	+	219	WP_223664962.1	hypothetical protein	-
KGP26_RS02095 (KGP26_02090)	474433..475008	-	576	WP_021807590.1	transcriptional regulator	-
KGP26_RS02100 (KGP26_02095)	475049..476764	-	1716	WP_223664963.1	protein-disulfide reductase DsbD	-
KGP26_RS02105 (KGP26_02100)	476740..477063	-	324	WP_021807588.1	divalent cation tolerance protein CutA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (41-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (14-89)

Sequences

Toxin

Protein

• Length: 163 a.a.
• Molecular weight: 17879.95 Da
• Isoelectric Point: 7.6343

>T201606 WP_223664959.1 NZ_CP074143:c471870-471382 [Serratia sp. JSRIV002]
VISAPQPLRAEHVRTAFCCGVESMDNWLKQRAIKSQLTDSSRTFVCCDDMKIMAYYSLASSAVMTNAAPGRFRRNMPDPI
PMVELGRLAVDQALYGQGVGRALVRNAGLRVIQVAETIGIRGMLVNALSVEVREFYLRVGFEPSPLDPMMLMITLGDLIE
SL

Nucleotide

• Length: 489 bp

>T201606 NZ_CP098691:2855566-2855895 [Yersinia ruckeri]
ATGCAAACCTTATCATCACACCCGACACGGGCGTCTCAGCCCTGCCTGTCACCCGTTGAAATCTGGCAGCTGCTGCTGAC
TCATTTGTTGTCGCAGCACTATGGCCTGACGCTGAATGACACACCGTTCATTAATGAAACCACCATCCGGGAACATATTG
ATGCTGGAGTATCGCTCAGCGATGCGGTGAACTTTCTGGTAGAAAAATATGGGCTTGTCCGTATCGACCGGAAGGGATTT
TCGTGGCAAGAACAGACCCCATATATTTCCGTAGTTGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACCAA
CGTGAAATAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10871.46 Da
• Isoelectric Point: 10.1968

>AT201606 WP_223664960.1 NZ_CP074143:c472160-471867 [Serratia sp. JSRIV002]
MSAANSVPVKRETLNLRIKTAERELIDRAAKARGKNRTDFVLDAARAAAEEALIEQHIIMAAPEAYQEFLTRLDQAPAPN
DALRKTMRSVAPWDQKK

Nucleotide

• Length: 294 bp

>AT201606 NZ_CP098691:2855162-2855527 [Yersinia ruckeri]
ATGAACAATCACTCAGAATCCGTTACCAAGCCGGAGAATCCCGCCTGCCAGCAGTGGGGACTAAAGAGTACGATCACACC
CTGTTTTGGAGCTCGTCTGGTGCTGGAAGGCAACCGCTTGCATTTTCTCGCTGACCGGGCCGGATTCAACGGTGCTTTCA
GCGACGATGACGCGCTGCACCTAGATCATGCCTTTCCGTTGATACTCAAGCAACTGGAGCTGATGCTCACCAGCGGAGAA
CTCTCTCCCCGGCATCAGCACTGCGTCACGCTATATCACAACGGACTCACTTGCGAAGCCGACACACTCGGCTCCTGTGG
CTATGTCTACATTGCTATTTATCCTGACCAGACTGAGCCGCAGTAA